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Gene

SAT1

spermidine/spermine N1-acetyltransferase 1

Summary

Cytogenetic location
Xp22.11
Coordinates
Chromosome X: 23,783,173–23,786,210 (GRCh38)
Exons
6 exons across 3 kb
Protein
171 amino acids
Also known as
SSAT
Previous symbols
SAT
MANE Select transcript
ENST00000379270.5NM_002970.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

  • Autoimmune Disease

    • A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis).

      • 1 GenCC submitter rates it definitive or strong

  • Systemic Lupus Erythematosus

    • An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Standard SLE: hydroxychloroquine, mycophenolate, belimumab, anifrolumab; Complement-deficient lupus: FFP replacement; Interferonopathy: anifrolumab, JAK inhibitors; All: sun protection, cardiovascular risk management, pregnancy planning

How SAT1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome X, with a bracket where SAT1 sits. SAT1 and 9 genes near it on chromosome X, from 23,284,692 to 24,284,691.Chromosome XXp22.11p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q2823.4 Mb23.6 Mb23.8 Mb24 Mb24.2 MbPTCHD1: 23,334,076–23,404,374, forward strandPTCHD1PRDX4: 23,664,262–23,700,980, forward strandPRDX4ACOT9: 23,699,396–23,766,475, reverse strandACOT9SAT1: 23,783,173–23,786,210, forward strandSAT1: 23,783,278–23,783,367, forward strandAPOO: 23,833,348–23,908,070, reverse strandAPOOCXorf58: 23,907,807–23,939,509, forward strandCXorf58KLHL15: 23,983,716–24,027,186, reverse strandKLHL15EIF2S3: 24,054,628–24,078,810, forward strandEIF2S3ZFX: 24,148,970–24,216,255, forward strandZFXDiagram of SAT1: 6 exons on the forward strand of chromosome XExon 1: 23,783,173–23,783,417, 245 basesExon 2: 23,783,658–23,783,709, 52 basesExon 3: 23,783,800–23,783,883, 84 basesExon 4: 23,785,328–23,785,429, 102 basesExon 5: 23,785,520–23,785,560, 41 basesExon 6: 23,785,686–23,786,210, 525 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1 kb of the gene's 3 kb; 516 of those bases code for the protein.

Genes linked to the same conditions

Traits linked to SAT1

The Human Phenotype Ontology lists these as features of the rare conditions SAT1 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SAT1 gene: spermidine/spermine N1-acetyltransferase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/sat1

Vancouver

Dante Labs. SAT1 gene: spermidine/spermine N1-acetyltransferase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/sat1

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