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Gene

PSMB10

proteasome 20S subunit beta 10

Summary

Cytogenetic location
16q22.1
Coordinates
Chromosome 16: 67,934,506–67,936,850 (GRCh38)
Exons
8 exons across 2.3 kb
Protein
273 amino acids
Inheritance
Autosomal dominant Autosomal recessive
Also known as
LMP10, MGC1665, beta2i
Previous symbols
MECL1
MANE Select transcript
ENST00000358514.9NM_002801.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Rare Monogenic Autoinflammatory Diseases

    • PTPN2-related autoinflammation and autoimmunityAutosomal dominant

      Early-onset inflammatory and autoimmune disease, including colitis and arthritis, caused by variants in PTPN2.

      • 1 GenCC submitter rates it definitive or strong

  • Type I Interferonopathies

    • Proteasome-associated autoinflammatory syndromes (CANDLE/PRAAS)Autosomal recessive

      Recurrent fevers, skin lesions, loss of fat tissue and joint problems caused by defects in the proteasome (PSMB8, PSMB9, PSMB10, POMP and others).

      • 1 GenCC submitter rates it definitive or strong

Broader groupings

  • Other Inborn Errors of Immunity

    • Immunodeficiency Disease

      One of 170 genes linked to it

      Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.
Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How PSMB10 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 16, with a bracket where PSMB10 sits. PSMB10 and 35 genes near it on chromosome 16, from 67,435,678 to 68,435,677.Chromosome 1616q22.1p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.367.6 Mb67.8 Mb68 Mb68.2 Mb68.4 MbHSD11B2: 67,430,652–67,437,553, forward strandHSD11B2ATP6V0D1: 67,437,523–67,481,227, reverse strandATP6V0D1AGRP: 67,482,571–67,483,552, reverse strandAGRPRIPOR1: 67,518,418–67,546,788, forward strandRIPOR1CTCF: 67,561,831–67,639,189, forward strandCARMIL2: 67,644,988–67,657,569, forward strandACD: 67,657,512–67,660,810, reverse strandPARD6A: 67,660,350–67,664,266, forward strandPARD6AENKD1: 67,662,945–67,667,954, reverse strandENKD1C16orf86: 67,666,802–67,668,757, forward strandC16orf86GFOD2: 67,674,527–67,719,352, reverse strandGFOD2RANBP10: 67,723,070–67,806,563, reverse strandRANBP10TSNAXIP1: 67,806,765–67,832,148, forward strandTSNAXIP1CENPT: 67,828,157–67,847,811, reverse strandTHAP11: 67,842,320–67,844,195, forward strandTHAP11NUTF2: 67,844,369–67,872,569, forward strandNUTF2EDC4: 67,873,049–67,884,520, forward strandEDC4NRN1L: 67,884,868–67,888,855, forward strandNRN1LPSKH1: 67,893,244–67,929,676, forward strandCTRL: 67,927,640–67,932,365, reverse strandCTRL: 67,929,614–67,936,017, reverse strandPSMB10: 67,934,506–67,936,850, reverse strandPSMB10LCAT: 67,939,150–67,944,681, reverse strandLCATSLC12A4: 67,943,474–67,969,601, reverse strandDPEP3: 67,975,661–67,980,554, reverse strandDPEP3DPEP2: 67,987,392–68,000,624, reverse strandDPEP2DUS2: 67,987,746–68,079,344, forward strandDPEP2NB: 68,013,436–68,015,911, reverse strandDPEP2NBDDX28: 68,020,916–68,023,232, reverse strandDDX28NFATC3: 68,084,751–68,229,259, forward strandNFATC3ESRP2: 68,225,974–68,238,102, reverse strandESRP2PLA2G15: 68,245,304–68,261,063, forward strandPLA2G15SLC7A6: 68,264,173–68,301,853, forward strandSLC7A6SLC7A6OS: 68,284,498–68,310,968, reverse strandSLC7A6OSPRMT7: 68,310,916–68,360,852, forward strandPRMT7SMPD3: 68,358,327–68,448,550, reverse strandSMPD3Diagram of PSMB10: 8 exons on the reverse strand of chromosome 16Exon 7: 1 known disease-causing siteExon 8: 67,934,506–67,934,671, 166 basesExon 7: 67,934,797–67,934,948, 152 basesExon 6: 67,935,420–67,935,478, 59 basesExon 5: 67,935,582–67,935,697, 116 basesExon 4: 67,935,963–67,936,103, 141 basesExon 3: 67,936,215–67,936,312, 98 basesExon 2: 67,936,398–67,936,485, 88 basesExon 1: 67,936,694–67,936,850, 157 bases876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1 kb of the gene's 2.3 kb; 822 of those bases code for the protein.

How a genome test reads PSMB10

2

positions in PSMB10 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 2.3 kb of PSMB10, introns included, not only the 1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PSMB10 gene: proteasome 20S subunit beta 10. Retrieved 17 October 2026, from https://dantelabs.com/genes/psmb10

Vancouver

Dante Labs. PSMB10 gene: proteasome 20S subunit beta 10 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/psmb10

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