Skip to content
Use your HSA or FSA funds

Gene

TRPC6

transient receptor potential cation channel subfamily C member 6

Summary

Cytogenetic location
11q22.1
Coordinates
Chromosome 11: 101,451,564–101,584,007 (GRCh38)
Exons
13 exons across 132.4 kb
Protein
931 amino acids
Also known as
TRP6
Previous symbols
FSGS2
MANE Select transcript
ENST00000344327.8NM_004621.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Focal Segmental Glomerulosclerosis

    • A renal disorder characterized by sclerotic lesions in the glomeruli. Causes include drugs, viruses, and malignancies (lymphomas), or it may be idiopathic. It presents with asymptomatic proteinuria or nephritic syndrome and it may lead to renal failure.

      • 3 GenCC submitters rate it definitive or strong

  • Glomerulosclerosis

    • A hardening of the kidney glomerulus caused by scarring of the blood vessels.

      • 3 GenCC submitters rate it definitive or strong

How TRPC6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where TRPC6 sits. TRPC6 and 3 genes near it on chromosome 11, from 101,017,786 to 102,017,785.Chromosome 1111q22.1p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25101.2 Mb101.4 Mb101.6 Mb101.8 Mb102 MbPGR: 101,029,624–101,129,817, reverse strandPGRTRPC6: 101,451,564–101,584,007, reverse strandTRPC6ANGPTL5: 101,890,660–102,026,456, reverse strandANGPTL5CEP126: 101,914,997–102,001,062, forward strandCEP126Diagram of TRPC6: 13 exons on the reverse strand of chromosome 11Exon 13: 4 known disease-causing sitesExon 12: 5 known disease-causing sitesExon 10: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 6: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 3: 2 known disease-causing sitesExon 2: 5 known disease-causing sitesExon 1: 2 known disease-causing sitesExon 13: 101,451,564–101,453,106, 1,543 basesExon 12: 101,453,650–101,453,725, 76 basesExon 11: 101,455,018–101,455,101, 84 basesExon 10: 101,469,427–101,469,501, 75 basesExon 9: 101,471,183–101,471,386, 204 basesExon 8: 101,472,137–101,472,332, 196 basesExon 7: 101,473,509–101,473,773, 265 basesExon 6: 101,476,301–101,476,534, 234 basesExon 5: 101,482,949–101,483,165, 217 basesExon 4: 101,488,937–101,489,101, 165 basesExon 3: 101,491,556–101,491,738, 183 basesExon 2: 101,504,024–101,504,798, 775 basesExon 1: 101,583,334–101,584,007, 674 bases1310515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.7 kb of the gene's 132.4 kb; 2,796 of those bases code for the protein.

How a genome test reads TRPC6

29

positions in TRPC6 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 132.4 kb of TRPC6, introns included, not only the 4.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TRPC6 gene: transient receptor potential cation channel subfamily C member 6. Retrieved 16 October 2026, from https://dantelabs.com/genes/trpc6

Vancouver

Dante Labs. TRPC6 gene: transient receptor potential cation channel subfamily C member 6 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/trpc6

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test