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Gene

USB1

U6 snRNA biogenesis phosphodiesterase 1

Summary

Cytogenetic location
16q21
Coordinates
Chromosome 16: 58,001,407–58,021,618 (GRCh38)
Exons
7 exons across 20.2 kb
Protein
265 amino acids
Also known as
FLJ13154, HVSL1, Mpn1
Previous symbols
C16orf57
MANE Select transcript
ENST00000219281.8NM_024598.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads USB1 yet. The test sequences your whole genome, so your data includes it all the same.

How USB1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 16, with a bracket where USB1 sits. USB1 and 17 genes near it on chromosome 16, from 57,511,513 to 58,511,512.Chromosome 1616q21p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.357.6 Mb57.8 Mb58 Mb58.2 Mb58.4 MbCCDC102A: 57,511,805–57,537,163, reverse strandCCDC102AADGRG5: 57,528,585–57,591,681, forward strandADGRG5ADGRG1: 57,610,652–57,665,580, forward strandADGRG1ADGRG3: 57,668,106–57,689,378, forward strandADGRG3DRC7: 57,694,790–57,731,805, forward strandDRC7KATNB1: 57,735,669–57,758,271, forward strandKATNB1KIFC3: 57,755,668–57,863,053, reverse strandKIFC3CNGB1: 57,881,892–57,971,128, reverse strandCNGB1SPMIP8: 57,976,435–57,988,116, forward strandSPMIP8ZNF319: 57,994,673–58,000,718, reverse strandZNF319USB1: 58,001,407–58,021,618, forward strandUSB1MMP15: 58,025,555–58,046,901, forward strandMMP15CFAP20: 58,113,167–58,129,429, reverse strandCFAP20CSNK2A2: 58,157,907–58,198,191, reverse strandCSNK2A2CFAP263: 58,231,157–58,283,836, forward strandCFAP263PRSS54: 58,279,997–58,295,047, reverse strandPRSS54GINS3: 58,295,080–58,406,147, forward strandGINS3NDRG4: 58,462,846–58,513,628, forward strandNDRG4Diagram of USB1: 7 exons on the forward strand of chromosome 16Exon 1: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 1: 58,001,407–58,001,581, 175 basesExon 2: 58,002,479–58,002,645, 167 basesExon 3: 58,009,929–58,010,112, 184 basesExon 4: 58,014,273–58,014,326, 54 basesExon 5: 58,017,334–58,017,439, 106 basesExon 6: 58,018,972–58,019,055, 84 basesExon 7: 58,020,141–58,021,618, 1,478 bases12345675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 20.2 kb; 798 of those bases code for the protein.

How a genome test reads USB1

4

positions in USB1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 20.2 kb of USB1, introns included, not only the 2.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). USB1 gene: U6 snRNA biogenesis phosphodiesterase 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/usb1

Vancouver

Dante Labs. USB1 gene: U6 snRNA biogenesis phosphodiesterase 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/usb1

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