Gene
MYPN
myopalladin
- HGNC 23246(opens in a new tab)
- Ensembl gene ENSG00000138347(opens in a new tab)
- NCBI Gene 84665(opens in a new tab)
Summary
- Cytogenetic location
- 10q21.3
- Coordinates
- Chromosome 10: 68,109,488–68,212,017 (GRCh38)
- Exons
- 20 exons across 102.5 kb
- Protein
- 1,320 amino acids
- Inheritance
- Autosomal dominant
- Also known as
- MYOP
- MANE Select transcript
- ENST00000358913.10NM_032578.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
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Congenital Myopathies
- Nemaline myopathy
A congenital myopathy defined by rod-shaped structures in muscle fibers, most often caused by NEB or ACTA1 variants.
- ClinGen rates the link definitive
- 4 GenCC submitters rate it definitive or strong
Dilated Cardiomyopathy
Enlargement and weakening of the left ventricle not explained by coronary artery or valve disease; inherited forms involve TTN, LMNA, RBM20, FLNC, BAG3, DSP, MYH7, TNNT2, DES, PLN and many other genes, and include Barth syndrome and the Emery-Dreifuss muscular dystrophies.
- 1 GenCC submitter rates it definitive or strong
What knowing changes
Knowing a genetic cause supports earlier heart monitoring and family screening, and for genes with a high arrhythmia risk such as LMNA, FLNC and RBM20 it informs decisions about rhythm monitoring and implantable defibrillators.
Broader groupings
Hypertrophic Cardiomyopathy
- Autosomal dominant
One of 62 genes linked to it
A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.
- 1 GenCC submitter rates it definitive or strong
What knowing changes
Beta-blockers, non-dihydropyridine calcium channel blockers, activity restriction, genetic counseling
Inheritance
- Autosomal dominant
- One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.
How MYPN is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 5.8 kb of the gene's 102.5 kb; 3,963 of those bases code for the protein.
How a genome test reads MYPN
66
positions in MYPN where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 102.5 kb of MYPN, introns included, not only the 5.8 kb of exons.
Traits linked to MYPN
The Human Phenotype Ontology lists these as features of the rare conditions MYPN can cause. Each trait's page lists the other genes linked to it.
Abnormality of the musculoskeletal system
- Muscle weakness
- Type 1 muscle fiber predominance
- EMG: myopathic abnormalities
- Muscle tissue disease
- Abnormal muscle fiber morphology
- Generalized muscle wasting
- Increased variability in muscle fiber diameter
- Muscle stiffness
Show 23 more traits
- Reduced spine movement
- Decreased lung function due to weak breathing muscles
- Difficulty running
- Difficulty walking up stairs
- Diffuse skeletal muscle wasting
- EMG abnormality
- Excessive inward curvature of lower spine
- Fatigable weakness of bulbar muscles
- Fatiguable weakness of proximal limb muscles
- Flexed joint that cannot be straightened
- Frequent falls
- Funnel chest
- Generalized decreased muscle tone
- Gowers sign
- Loss of fat tissue in localized area
- Lower limb amyotrophy
- Narrow chest
- Neck muscle weakness
- Poor head control
- Scoliosis
- Thoracic scoliosis
- Tired easily
- Arthrogryposis multiplex congenita
Abnormality of the cardiovascular system
- Stretched and thinned heart muscle
- Abnormal left ventricular function
- Increased left ventricular end-diastolic volume
- Left ventricular systolic dysfunction
- Abnormal heart rate
- Cardiac failure
- Disease of the heart muscle
- Interstitial cardiac fibrosis
Show 17 more traits
- Left atrial enlargement
- Pulmonary venous hypertension
- Right atrial enlargement
- Bulge in wall of root of large artery that carries blood away from heart
- Enlarged and thickened heart muscle
- First degree atrioventricular block
- Left ventricular hypertrophy
- Mitral regurgitation
- Mitral valve prolapse
- Quivering upper heart chambers resulting in irregular heartbeat
- Reduced systolic function
- Sinus tachycardia
- Supraventricular arrhythmia
- Tricuspid regurgitation
- Fainting spell
- Stroke
- Ventricular septal hypertrophy
Abnormality of the nervous system
- Abnormal gait
- Clumsiness
- Decreased reflex response
- Diminished deep tendon reflex
- Motor delay
- Slow movements
- Waddling gait
- Absent reflexes
Show 3 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). MYPN gene: myopalladin. Retrieved 16 October 2026, from https://dantelabs.com/genes/mypn
Dante Labs. MYPN gene: myopalladin [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/mypn
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