Trait
Swelling caused by excess lymph fluid under skin
Clinical name: Lymphedema
Localized fluid retention and tissue swelling caused by a compromised lymphatic system.
Summary
- Also called
- Lymphatic obstruction, Lymphoedema, Onset of lymphedema around puberty
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
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Get my Genome Test75 genes linked to Swelling caused by excess lymph fluid under skin
Changes in these genes cause rare conditions in which Swelling caused by excess lymph fluid under skin is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3 | Always | In 2 conditions |
| ANGPT2angiopoietin 2 | Always | In 1 condition |
| CCBE1collagen and calcium binding EGF domains 1 | Always | In 2 conditions |
| CDC42cell division cycle 42 | Always | In 2 conditions |
| CDK5cyclin dependent kinase 5 | Always | In 1 condition |
| EPHB4EPH receptor B4 | Always | In 2 conditions |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| MDFICMyoD family inhibitor domain containing | Always | In 1 condition |
| SOX18SRY-box transcription factor 18 | Always | In 1 condition |
| VEGFCvascular endothelial growth factor C | Always | In 1 condition |
| ANTXR2ANTXR cell adhesion molecule 2 | Very often (80–99%) | In 1 condition |
| FAT4FAT atypical cadherin 4 | Very often (80–99%) | In 3 conditions |
| FLT4fms related receptor tyrosine kinase 4 | Very often (80–99%) | In 1 condition |
| GATA2GATA binding protein 2 | Very often (80–99%) | In 2 conditions |
| GUSBglucuronidase beta | Very often (80–99%) | In 1 condition |
| INPPL1inositol polyphosphate phosphatase like 1 | Very often (80–99%) | In 1 condition |
| KIF11kinesin family member 11 | Very often (80–99%) | In 2 conditions |
| LBRlamin B receptor | Very often (80–99%) | In 1 condition |
| SLC35D1solute carrier family 35 member D1 | Very often (80–99%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Often (30–79%) | In 1 condition |
| GNA14G protein subunit alpha 14 | Often (30–79%) | In 1 condition |
| KIF7kinesin family member 7 | Often (30–79%) | In 1 condition |
| NAGAalpha-N-acetylgalactosaminidase | Often (30–79%) | In 3 conditions |
| NLRP3NLR family pyrin domain containing 3 | Often (30–79%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Often (30–79%) | In 2 conditions |
| PTPN14protein tyrosine phosphatase non-receptor type 14 | Often (30–79%) | In 1 condition |
| SHANK3SH3 and multiple ankyrin repeat domains 3 | Often (30–79%) | In 1 condition |
| TIE1tyrosine kinase with immunoglobulin like and EGF like domains 1 | Often (30–79%) | In 1 condition |
| XYLT2xylosyltransferase 2 | Often (30–79%) | In 1 condition |
| ACVR1activin A receptor type 1 | Sometimes (5–29%) | In 1 condition |
| BCL2BCL2 apoptosis regulator | Sometimes (5–29%) | In 1 condition |
| BCL6BCL6 transcription repressor | Sometimes (5–29%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Sometimes (5–29%) | In 3 conditions |
| CBLCbl proto-oncogene | Sometimes (5–29%) | In 2 conditions |
| CTNNB1catenin beta 1 | Sometimes (5–29%) | In 1 condition |
| DCHS1dachsous cadherin-related 1 | Sometimes (5–29%) | In 1 condition |
| FZD4frizzled class receptor 4 | Sometimes (5–29%) | In 1 condition |
| GLAgalactosidase alpha | Sometimes (5–29%) | In 2 conditions |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 1 condition |
Show 35 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| IGHimmunoglobulin heavy locus | Sometimes (5–29%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Sometimes (5–29%) | In 3 conditions |
| LRP5LDL receptor related protein 5 | Sometimes (5–29%) | In 1 condition |
| LZTR1leucine zipper like post translational regulator 1 | Sometimes (5–29%) | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Sometimes (5–29%) | In 2 conditions |
| MAP2K2mitogen-activated protein kinase kinase 2 | Sometimes (5–29%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Sometimes (5–29%) | In 1 condition |
| MRASmuscle RAS oncogene homolog | Sometimes (5–29%) | In 1 condition |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Sometimes (5–29%) | In 1 condition |
| NDPnorrin cystine knot growth factor NDP | Sometimes (5–29%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| PTENphosphatase and tensin homolog | Sometimes (5–29%) | In 1 condition |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Sometimes (5–29%) | In 2 conditions |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| RASA2RAS p21 protein activator 2 | Sometimes (5–29%) | In 1 condition |
| RIT1Ras like without CAAX 1 | Sometimes (5–29%) | In 1 condition |
| RRASRAS related | Sometimes (5–29%) | In 1 condition |
| RRAS2RAS related 2 | Sometimes (5–29%) | In 1 condition |
| SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 | Sometimes (5–29%) | In 1 condition |
| SOS2SOS Ras/Rho guanine nucleotide exchange factor 2 | Sometimes (5–29%) | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Sometimes (5–29%) | In 1 condition |
| SPRED2sprouty related EVH1 domain containing 2 | Sometimes (5–29%) | In 1 condition |
| TSC1TSC complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| TSC2TSC complex subunit 2 | Sometimes (5–29%) | In 1 condition |
| TSPAN12tetraspanin 12 | Sometimes (5–29%) | In 1 condition |
| ZNF408zinc finger protein 408 | Sometimes (5–29%) | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Rarely (1–4%) | In 1 condition |
| PMM2phosphomannomutase 2 | Rarely (1–4%) | In 1 condition |
| ABCC9ATP binding cassette subfamily C member 9 | Not recorded | In 1 condition |
| CELSR1cadherin EGF LAG seven-pass G-type receptor 1 | Not recorded | In 1 condition |
| ERGETS transcription factor ERG | Not recorded | In 1 condition |
| FOXC2forkhead box C2 | Not recorded | In 1 condition |
| GJC2gap junction protein gamma 2 | Not recorded | In 1 condition |
| PIEZO1piezo type mechanosensitive ion channel component 1 (Er blood group) | Not recorded | In 1 condition |
| RELNreelin | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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