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Gene

HERC2

HECT and RLD domain containing E3 ubiquitin protein ligase 2

Summary

Cytogenetic location
15q13.1
Coordinates
Chromosome 15: 28,111,040–28,322,179 (GRCh38)
Exons
93 exons across 211.1 kb
Protein
4,834 amino acids
Also known as
jdf2, p528, D15F37S1
MANE Select transcript
ENST00000261609.13NM_004667.6
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads HERC2 yet. The test sequences your whole genome, so your data includes it all the same.

How HERC2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where HERC2 sits. HERC2 and 6 genes near it on chromosome 15, from 27,716,610 to 28,716,609.Chromosome 1515q13.1p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.327.8 Mb28 Mb28.2 Mb28.4 Mb28.6 MbOCA2: 27,754,859–28,099,664, reverse strandOCA2HERC2: 28,111,040–28,322,179, reverse strandHERC2GOLGA6L24: 28,347,851–28,358,084, reverse strandGOLGA6L24GOLGA8F: 28,378,621–28,392,021, forward strandGOLGA8FGOLGA8G: 28,519,611–28,533,014, reverse strandGOLGA8GGOLGA6L25: 28,553,568–28,563,779, forward strandGOLGA6L25GOLGA8M: 28,698,583–28,738,384, reverse strandGOLGA8MDiagram of HERC2: 93 exons on the reverse strand of chromosome 15Exon 92: 1 known disease-causing siteExon 87: 1 known disease-causing siteExon 84: 1 known disease-causing siteExon 83: 1 known disease-causing siteExon 80: 1 known disease-causing siteExon 78: 1 known disease-causing siteExon 64: 1 known disease-causing siteExon 49: 1 known disease-causing siteExon 48: 1 known disease-causing siteExon 27: 1 known disease-causing siteExon 22: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 14: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 93: 28,111,040–28,112,035, 996 basesExon 92: 28,113,071–28,113,283, 213 basesExon 91: 28,113,573–28,113,678, 106 basesExon 90: 28,114,612–28,114,802, 191 basesExon 89: 28,115,429–28,115,541, 113 basesExon 88: 28,116,665–28,116,859, 195 basesExon 87: 28,117,013–28,117,154, 142 basesExon 86: 28,121,346–28,121,429, 84 basesExon 85: 28,124,037–28,124,234, 198 basesExon 84: 28,125,006–28,125,193, 188 basesExon 83: 28,130,163–28,130,302, 140 basesExon 82: 28,130,503–28,130,594, 92 basesExon 81: 28,132,100–28,132,261, 162 basesExon 80: 28,132,653–28,132,830, 178 basesExon 79: 28,135,478–28,135,692, 215 basesExon 78: 28,141,432–28,141,630, 199 basesExon 77: 28,141,731–28,141,846, 116 basesExon 76: 28,142,238–28,142,393, 156 basesExon 75: 28,142,827–28,142,952, 126 basesExon 74: 28,143,873–28,143,991, 119 basesExon 73: 28,144,077–28,144,235, 159 basesExon 72: 28,144,673–28,144,804, 132 basesExon 71: 28,146,237–28,146,344, 108 basesExon 70: 28,152,677–28,152,830, 154 basesExon 69: 28,163,094–28,163,285, 192 basesExon 68: 28,167,687–28,167,827, 141 basesExon 67: 28,168,407–28,168,590, 184 basesExon 66: 28,169,484–28,169,655, 172 basesExon 65: 28,174,395–28,174,620, 226 basesExon 64: 28,175,512–28,175,656, 145 basesExon 63: 28,176,428–28,176,599, 172 basesExon 62: 28,176,687–28,176,768, 82 basesExon 61: 28,176,950–28,177,127, 178 basesExon 60: 28,177,419–28,177,509, 91 basesExon 59: 28,178,887–28,179,030, 144 basesExon 58: 28,179,142–28,179,223, 82 basesExon 57: 28,182,401–28,182,512, 112 basesExon 56: 28,186,577–28,186,752, 176 basesExon 55: 28,190,965–28,191,056, 92 basesExon 54: 28,191,139–28,191,244, 106 basesExon 53: 28,191,961–28,192,151, 191 basesExon 52: 28,196,215–28,196,354, 140 basesExon 51: 28,196,461–28,196,569, 109 basesExon 50: 28,198,378–28,198,503, 126 basesExon 49: 28,198,601–28,198,769, 169 basesExon 48: 28,201,456–28,201,554, 99 basesExon 47: 28,202,113–28,202,249, 137 basesExon 46: 28,202,347–28,202,614, 268 basesExon 45: 28,206,240–28,206,382, 143 basesExon 44: 28,211,002–28,211,145, 144 basesExon 43: 28,212,445–28,212,583, 139 basesExon 42: 28,213,742–28,213,972, 231 basesExon 41: 28,214,076–28,214,272, 197 basesExon 40: 28,214,655–28,214,802, 148 basesExon 39: 28,215,621–28,215,802, 182 basesExon 38: 28,218,489–28,218,671, 183 basesExon 37: 28,220,452–28,220,644, 193 basesExon 36: 28,222,028–28,222,215, 188 basesExon 35: 28,228,218–28,228,409, 192 basesExon 34: 28,229,195–28,229,346, 152 basesExon 33: 28,229,460–28,229,596, 137 basesExon 32: 28,229,674–28,229,847, 174 basesExon 31: 28,230,367–28,230,500, 134 basesExon 30: 28,233,146–28,233,341, 196 basesExon 29: 28,233,434–28,233,561, 128 basesExon 28: 28,233,664–28,233,796, 133 basesExon 27: 28,234,070–28,234,284, 215 basesExon 26: 28,236,963–28,237,113, 151 basesExon 25: 28,238,114–28,238,217, 104 basesExon 24: 28,238,602–28,238,772, 171 basesExon 23: 28,245,881–28,246,066, 186 basesExon 22: 28,246,742–28,246,897, 156 basesExon 21: 28,248,552–28,248,736, 185 basesExon 20: 28,254,340–28,254,518, 179 basesExon 19: 28,255,872–28,255,996, 125 basesExon 18: 28,256,089–28,256,317, 229 basesExon 17: 28,257,061–28,257,261, 201 basesExon 16: 28,260,777–28,260,970, 194 basesExon 15: 28,262,918–28,263,169, 252 basesExon 14: 28,265,618–28,265,731, 114 basesExon 13: 28,265,817–28,265,974, 158 basesExon 12: 28,268,465–28,268,616, 152 basesExon 11: 28,269,248–28,269,436, 189 basesExon 10: 28,270,695–28,270,868, 174 basesExon 9: 28,272,215–28,272,386, 172 basesExon 8: 28,272,894–28,273,004, 111 basesExon 7: 28,274,291–28,274,447, 157 basesExon 6: 28,274,905–28,275,005, 101 basesExon 5: 28,280,068–28,280,287, 220 basesExon 4: 28,292,888–28,293,022, 135 basesExon 3: 28,299,402–28,299,516, 115 basesExon 2: 28,321,362–28,321,464, 103 basesExon 1: 28,322,075–28,322,179, 105 bases938060402015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 15.4 kb of the gene's 211.1 kb; 14,505 of those bases code for the protein.

How a genome test reads HERC2

16

positions in HERC2 where ClinVar classes a change as pathogenic or likely pathogenic

7 of them (44%) fall in regions short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (7 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 211.1 kb of HERC2, introns included, not only the 15.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HERC2 gene: HECT and RLD domain containing E3 ubiquitin protein ligase 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/herc2

Vancouver

Dante Labs. HERC2 gene: HECT and RLD domain containing E3 ubiquitin protein ligase 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/herc2

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