Özellikler

ZFX ile ilişkili özellikler

zinc finger protein X-linked

Human Phenotype Ontology, ZFX ile ilişkili 193 özelliği vücut sistemine göre listeliyor: genin nadir hastalıklarından birine sahip kişilerde görülen özellikler.

Abnormality of head or neck

Özellik	Ne sıklıkla görüldüğü
Big calvaria	Her zaman
Abnormally large tongue	Sık (%30–79)
Broad eyebrow	Sık (%30–79)
Eye folds	Sık (%30–79)
Long philtrum	Sık (%30–79)
Monobrow	Sık (%30–79)
Pointed chin	Sık (%30–79)
Smooth philtrum	Sık (%30–79)
Thin red part of the upper lip	Sık (%30–79)
Big lower jaw	Bazen (%5–29)
Broad forehead	Bazen (%5–29)
Broad nasal tip	Bazen (%5–29)
Broad neck	Bazen (%5–29)
Broad nostril	Bazen (%5–29)
Broad opening between the eyelids	Bazen (%5–29)
Bulbous nose	Bazen (%5–29)
Cleft palate	Bazen (%5–29)
Coarse facial features	Bazen (%5–29)
Corners of eye widely separated	Bazen (%5–29)
Decreased size of tooth	Bazen (%5–29)
Delayed closure of the soft spot on the skull	Bazen (%5–29)
Delayed eruption of teeth	Bazen (%5–29)
Delayed loss of baby teeth	Bazen (%5–29)
Dental crowding	Bazen (%5–29)
Depressed nasal bridge	Bazen (%5–29)
Downward slanting of the opening between the eyelids	Bazen (%5–29)
Dry eye syndrome	Bazen (%5–29)
Everted eyelid	Bazen (%5–29)
Extra teeth	Bazen (%5–29)
Frontal bossing	Bazen (%5–29)
Fullness around the eyes	Bazen (%5–29)
High frontal hairline	Bazen (%5–29)
High palate	Bazen (%5–29)
Highly arched eyebrow	Bazen (%5–29)
Little lower jaw	Bazen (%5–29)
Long face	Bazen (%5–29)
Long nose	Bazen (%5–29)
Low frontal hairline	Bazen (%5–29)
Low hairline at back of neck	Bazen (%5–29)
Low hanging columella	Bazen (%5–29)
Midface retrusion	Bazen (%5–29)
Narrow forehead	Bazen (%5–29)
Narrow opening between the eyelids	Bazen (%5–29)
Narrow palate	Bazen (%5–29)
Pierre-Robin sequence	Bazen (%5–29)
Prominent eyelashes	Bazen (%5–29)
Prominent forehead	Bazen (%5–29)
Protruding tongue	Bazen (%5–29)
Receding chin	Bazen (%5–29)
Relatively large head	Bazen (%5–29)
Skin tag in front of the ear	Bazen (%5–29)
Tall shaped head	Bazen (%5–29)
Thick eyebrow	Bazen (%5–29)
Upward slanting of the opening between the eyelids	Bazen (%5–29)
Wide mouth	Bazen (%5–29)
Wider-than-typical soft spot of skull	Bazen (%5–29)
Zygomatic flattening	Bazen (%5–29)

Abnormality of the nervous system

Özellik	Ne sıklıkla görüldüğü
Epilepsy	Her zaman
Intellectual disability	Her zaman
Delayed ability to walk	Çok sık (%80–99)
Delayed fine motor development	Çok sık (%80–99)
Delayed speech and language development	Çok sık (%80–99)
Attention deficit	Sık (%30–79)
Autism	Sık (%30–79)
Global developmental delay	Sık (%30–79)
Intellectual disability, mild	Sık (%30–79)
Aggressive behavior	Bazen (%5–29)
Agitation	Bazen (%5–29)
Anxiety	Bazen (%5–29)
Boiling mad	Bazen (%5–29)
Brief seizures with staring spells	Bazen (%5–29)
Choroid plexus cyst	Bazen (%5–29)
Degeneration of cerebrum	Bazen (%5–29)
Delayed CNS myelination	Bazen (%5–29)
Depression	Bazen (%5–29)
Fluid-filled sac located in membrane surrounding brain or spinal cord	Bazen (%5–29)
Increased appetite	Bazen (%5–29)
Involuntary movements	Bazen (%5–29)
IQ between 34 and 49	Bazen (%5–29)
Low frustration tolerance	Bazen (%5–29)
Obstructive sleep apnea	Bazen (%5–29)
Periventricular leukomalacia	Bazen (%5–29)
Snoring	Bazen (%5–29)
Teeth grinding	Bazen (%5–29)
Underdevelopment of part of brain called corpus callosum	Bazen (%5–29)

Abnormality of the eye

Özellik	Ne sıklıkla görüldüğü
Close sighted	Her zaman
Involuntary, rapid, rhythmic eye movements	Her zaman
Visual impairment	Her zaman
Astigmatism	Bazen (%5–29)
Clouding of the lens of the eye	Bazen (%5–29)
Congenital nystagmus	Bazen (%5–29)
Cross-eyed	Bazen (%5–29)
Farsightedness	Bazen (%5–29)
Glaucoma	Bazen (%5–29)
Lazy eye	Bazen (%5–29)
Optic atrophy	Bazen (%5–29)
Optic nerve hypoplasia	Bazen (%5–29)
Retinal detachment	Bazen (%5–29)
Severe near sightedness	Bazen (%5–29)
Superior oblique muscle weakness	Bazen (%5–29)
Wide-set eyes	Bazen (%5–29)

Abnormality of the musculoskeletal system

Özellik	Ne sıklıkla görüldüğü
Double-Jointed	Her zaman
Scoliosis	Her zaman
Low muscle tone	Sık (%30–79)
Abnormal formation of the hip	Bazen (%5–29)
Absence of some of the sacral and coccygeal bones	Bazen (%5–29)
Delayed bone maturation	Bazen (%5–29)
Displacement of one backbone compared to another	Bazen (%5–29)
Flattened vertebrae	Bazen (%5–29)
Funnel chest	Bazen (%5–29)
Irregular vertebral endplates	Bazen (%5–29)
Joint dislocation	Bazen (%5–29)
Narrow spinal canal	Bazen (%5–29)
Osteopenia	Bazen (%5–29)
Pigeon chest	Bazen (%5–29)
Spondylolysis	Bazen (%5–29)
Thoracic scoliosis	Bazen (%5–29)

Abnormality of limbs

Özellik	Ne sıklıkla görüldüğü
Bunion	Bazen (%5–29)
Clubbing of fingers and toes	Bazen (%5–29)
Curvature of digit	Bazen (%5–29)
Deep palm line	Bazen (%5–29)
Finger joint hyperextensibility	Bazen (%5–29)
Finger syndactyly	Bazen (%5–29)
Front half of foot turns inward	Bazen (%5–29)
Large hands	Bazen (%5–29)
Overlapping toe	Bazen (%5–29)
Postaxial polydactyly	Bazen (%5–29)
Short foot	Bazen (%5–29)
Short toe	Bazen (%5–29)
Single transverse palmar crease	Bazen (%5–29)
Small toe	Bazen (%5–29)
Tapered finger	Bazen (%5–29)

Abnormality of the digestive system

Özellik	Ne sıklıkla görüldüğü
Feeding difficulties	Her zaman
Inguinal hernia	Sık (%30–79)
Umbilical hernia	Sık (%30–79)
Constipation	Bazen (%5–29)
Delayed gastric emptying	Bazen (%5–29)
Hepatocellular adenoma	Bazen (%5–29)
Inflammation of the esophagus	Bazen (%5–29)
Poor suck	Bazen (%5–29)
Poor swallowing	Bazen (%5–29)
Pyloric stenosis	Bazen (%5–29)
Rectum protrudes through anus	Bazen (%5–29)
Vomiting	Bazen (%5–29)

Abnormality of the cardiovascular system

Özellik	Ne sıklıkla görüldüğü
Patent ductus arteriosus	Sık (%30–79)
An opening in the wall separating the top two chambers of the heart	Bazen (%5–29)
Aortic valve has two leaflets rather than three	Bazen (%5–29)
Bulge in wall of root of large artery that carries blood away from heart	Bazen (%5–29)
Dilation of Virchow-Robin spaces	Bazen (%5–29)
High blood pressure	Bazen (%5–29)
Hole in heart wall separating two lower heart chambers	Bazen (%5–29)
Mesocardia	Bazen (%5–29)
Narrowing of aorta	Bazen (%5–29)

Abnormality of the ear

Özellik	Ne sıklıkla görüldüğü
Sensorineural hearing impairment	Sık (%30–79)
Asymmetric ears	Bazen (%5–29)
Conductive deafness	Bazen (%5–29)
Cupped ear	Bazen (%5–29)
Ears rotated toward back of head	Bazen (%5–29)
Large earlobe	Bazen (%5–29)
Low-set ears	Bazen (%5–29)
Overfolded ears	Bazen (%5–29)
Thickened helices	Bazen (%5–29)

Abnormality of the integument

Özellik	Ne sıklıkla görüldüğü
Excessive hair growth	Her zaman
Absence of part of skin at birth	Bazen (%5–29)
Deep-set nails	Bazen (%5–29)
Fair hair	Bazen (%5–29)
Fine hair	Bazen (%5–29)
Partial absent skin pigmentation	Bazen (%5–29)
Slow-growing hair	Bazen (%5–29)
Small nail	Bazen (%5–29)
Thick hair	Bazen (%5–29)

Abnormality of the endocrine system

Özellik	Ne sıklıkla görüldüğü
Delayed puberty	Bazen (%5–29)
Elevated blood parathyroid hormone level	Bazen (%5–29)
Hypogonadotropic hypogonadism	Bazen (%5–29)
Parathyroid adenoma	Bazen (%5–29)
Small pituitary gland	Bazen (%5–29)
Underactive thyroid	Bazen (%5–29)

Abnormality of the genitourinary system

Özellik	Ne sıklıkla görüldüğü
Hypospadias	Sık (%30–79)
Undescended testes	Sık (%30–79)
Horseshoe kidney	Bazen (%5–29)
Hydronephrosis	Bazen (%5–29)
Increased calcium level in kidney	Bazen (%5–29)
Kidney stone	Bazen (%5–29)

Abnormality of prenatal development or birth

Özellik	Ne sıklıkla görüldüğü
Caesarean section	Sık (%30–79)
Premature birth	Sık (%30–79)
High levels of amniotic fluid	Bazen (%5–29)
Low levels of amniotic fluid	Bazen (%5–29)

Abnormality of blood and blood-forming tissues

Özellik	Ne sıklıkla görüldüğü
Bleeding in brain	Bazen (%5–29)
Subarachnoid hemorrhage	Bazen (%5–29)
Subdural hemorrhage	Bazen (%5–29)

Constitutional symptom

Özellik	Ne sıklıkla görüldüğü
Chronic pain	Bazen (%5–29)

Growth abnormality

Özellik	Ne sıklıkla görüldüğü
Birth weight > 90th percentile	Bazen (%5–29)

Laboratory abnormality

Özellik	Ne sıklıkla görüldüğü
High blood calcium levels	Bazen (%5–29)

Bu özelliğin, genin ilişkili olduğu durumlardan birine sahip kişiler arasında ne sıklıkta görüldüğü; Human Phenotype Ontology'nin kaydettiği şekliyle, bunlar arasında en sık görülen oran. Bu sayfalar özellikleri ve bunların arkasındaki araştırmaları anlatır; tanı koymaz. Belirtiler hakkında bir doktora veya genetik danışmana başvurmanız gerekir.

Bilgilerin kaynağı

Human Phenotype Ontology, 2026-09-01 sürümü: ZFX ile ilişkili özellikler ve her birinin ne sıklıkla görüldüğü. Daha fazla bilgi için hpo.jax.org adresini ziyaret edin.

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