Tratti

Tratti collegati a ZFX

zinc finger protein X-linked

La Human Phenotype Ontology collega 193 tratti a ZFX, per sistema corporeo: caratteristiche osservate in persone con una delle condizioni rare del gene.

Abnormality of head or neck

Tratto	Frequenza di osservazione
Big calvaria	Sempre
Abnormally large tongue	Spesso (30–79%)
Broad eyebrow	Spesso (30–79%)
Eye folds	Spesso (30–79%)
Long philtrum	Spesso (30–79%)
Monobrow	Spesso (30–79%)
Pointed chin	Spesso (30–79%)
Smooth philtrum	Spesso (30–79%)
Thin red part of the upper lip	Spesso (30–79%)
Big lower jaw	A volte (5–29%)
Broad forehead	A volte (5–29%)
Broad nasal tip	A volte (5–29%)
Broad neck	A volte (5–29%)
Broad nostril	A volte (5–29%)
Broad opening between the eyelids	A volte (5–29%)
Bulbous nose	A volte (5–29%)
Cleft palate	A volte (5–29%)
Coarse facial features	A volte (5–29%)
Corners of eye widely separated	A volte (5–29%)
Decreased size of tooth	A volte (5–29%)
Delayed closure of the soft spot on the skull	A volte (5–29%)
Delayed eruption of teeth	A volte (5–29%)
Delayed loss of baby teeth	A volte (5–29%)
Dental crowding	A volte (5–29%)
Depressed nasal bridge	A volte (5–29%)
Downward slanting of the opening between the eyelids	A volte (5–29%)
Dry eye syndrome	A volte (5–29%)
Everted eyelid	A volte (5–29%)
Extra teeth	A volte (5–29%)
Frontal bossing	A volte (5–29%)
Fullness around the eyes	A volte (5–29%)
High frontal hairline	A volte (5–29%)
High palate	A volte (5–29%)
Highly arched eyebrow	A volte (5–29%)
Little lower jaw	A volte (5–29%)
Long face	A volte (5–29%)
Long nose	A volte (5–29%)
Low frontal hairline	A volte (5–29%)
Low hairline at back of neck	A volte (5–29%)
Low hanging columella	A volte (5–29%)
Midface retrusion	A volte (5–29%)
Narrow forehead	A volte (5–29%)
Narrow opening between the eyelids	A volte (5–29%)
Narrow palate	A volte (5–29%)
Pierre-Robin sequence	A volte (5–29%)
Prominent eyelashes	A volte (5–29%)
Prominent forehead	A volte (5–29%)
Protruding tongue	A volte (5–29%)
Receding chin	A volte (5–29%)
Relatively large head	A volte (5–29%)
Skin tag in front of the ear	A volte (5–29%)
Tall shaped head	A volte (5–29%)
Thick eyebrow	A volte (5–29%)
Upward slanting of the opening between the eyelids	A volte (5–29%)
Wide mouth	A volte (5–29%)
Wider-than-typical soft spot of skull	A volte (5–29%)
Zygomatic flattening	A volte (5–29%)

Abnormality of the nervous system

Tratto	Frequenza di osservazione
Epilepsy	Sempre
Intellectual disability	Sempre
Delayed ability to walk	Molto spesso (80–99%)
Delayed fine motor development	Molto spesso (80–99%)
Delayed speech and language development	Molto spesso (80–99%)
Attention deficit	Spesso (30–79%)
Autism	Spesso (30–79%)
Global developmental delay	Spesso (30–79%)
Intellectual disability, mild	Spesso (30–79%)
Aggressive behavior	A volte (5–29%)
Agitation	A volte (5–29%)
Anxiety	A volte (5–29%)
Boiling mad	A volte (5–29%)
Brief seizures with staring spells	A volte (5–29%)
Choroid plexus cyst	A volte (5–29%)
Degeneration of cerebrum	A volte (5–29%)
Delayed CNS myelination	A volte (5–29%)
Depression	A volte (5–29%)
Fluid-filled sac located in membrane surrounding brain or spinal cord	A volte (5–29%)
Increased appetite	A volte (5–29%)
Involuntary movements	A volte (5–29%)
IQ between 34 and 49	A volte (5–29%)
Low frustration tolerance	A volte (5–29%)
Obstructive sleep apnea	A volte (5–29%)
Periventricular leukomalacia	A volte (5–29%)
Snoring	A volte (5–29%)
Teeth grinding	A volte (5–29%)
Underdevelopment of part of brain called corpus callosum	A volte (5–29%)

Abnormality of the eye

Tratto	Frequenza di osservazione
Close sighted	Sempre
Involuntary, rapid, rhythmic eye movements	Sempre
Visual impairment	Sempre
Astigmatism	A volte (5–29%)
Clouding of the lens of the eye	A volte (5–29%)
Congenital nystagmus	A volte (5–29%)
Cross-eyed	A volte (5–29%)
Farsightedness	A volte (5–29%)
Glaucoma	A volte (5–29%)
Lazy eye	A volte (5–29%)
Optic atrophy	A volte (5–29%)
Optic nerve hypoplasia	A volte (5–29%)
Retinal detachment	A volte (5–29%)
Severe near sightedness	A volte (5–29%)
Superior oblique muscle weakness	A volte (5–29%)
Wide-set eyes	A volte (5–29%)

Abnormality of the musculoskeletal system

Tratto	Frequenza di osservazione
Double-Jointed	Sempre
Scoliosis	Sempre
Low muscle tone	Spesso (30–79%)
Abnormal formation of the hip	A volte (5–29%)
Absence of some of the sacral and coccygeal bones	A volte (5–29%)
Delayed bone maturation	A volte (5–29%)
Displacement of one backbone compared to another	A volte (5–29%)
Flattened vertebrae	A volte (5–29%)
Funnel chest	A volte (5–29%)
Irregular vertebral endplates	A volte (5–29%)
Joint dislocation	A volte (5–29%)
Narrow spinal canal	A volte (5–29%)
Osteopenia	A volte (5–29%)
Pigeon chest	A volte (5–29%)
Spondylolysis	A volte (5–29%)
Thoracic scoliosis	A volte (5–29%)

Abnormality of limbs

Tratto	Frequenza di osservazione
Bunion	A volte (5–29%)
Clubbing of fingers and toes	A volte (5–29%)
Curvature of digit	A volte (5–29%)
Deep palm line	A volte (5–29%)
Finger joint hyperextensibility	A volte (5–29%)
Finger syndactyly	A volte (5–29%)
Front half of foot turns inward	A volte (5–29%)
Large hands	A volte (5–29%)
Overlapping toe	A volte (5–29%)
Postaxial polydactyly	A volte (5–29%)
Short foot	A volte (5–29%)
Short toe	A volte (5–29%)
Single transverse palmar crease	A volte (5–29%)
Small toe	A volte (5–29%)
Tapered finger	A volte (5–29%)

Abnormality of the digestive system

Tratto	Frequenza di osservazione
Feeding difficulties	Sempre
Inguinal hernia	Spesso (30–79%)
Umbilical hernia	Spesso (30–79%)
Constipation	A volte (5–29%)
Delayed gastric emptying	A volte (5–29%)
Hepatocellular adenoma	A volte (5–29%)
Inflammation of the esophagus	A volte (5–29%)
Poor suck	A volte (5–29%)
Poor swallowing	A volte (5–29%)
Pyloric stenosis	A volte (5–29%)
Rectum protrudes through anus	A volte (5–29%)
Vomiting	A volte (5–29%)

Abnormality of the cardiovascular system

Tratto	Frequenza di osservazione
Patent ductus arteriosus	Spesso (30–79%)
An opening in the wall separating the top two chambers of the heart	A volte (5–29%)
Aortic valve has two leaflets rather than three	A volte (5–29%)
Bulge in wall of root of large artery that carries blood away from heart	A volte (5–29%)
Dilation of Virchow-Robin spaces	A volte (5–29%)
High blood pressure	A volte (5–29%)
Hole in heart wall separating two lower heart chambers	A volte (5–29%)
Mesocardia	A volte (5–29%)
Narrowing of aorta	A volte (5–29%)

Abnormality of the ear

Tratto	Frequenza di osservazione
Sensorineural hearing impairment	Spesso (30–79%)
Asymmetric ears	A volte (5–29%)
Conductive deafness	A volte (5–29%)
Cupped ear	A volte (5–29%)
Ears rotated toward back of head	A volte (5–29%)
Large earlobe	A volte (5–29%)
Low-set ears	A volte (5–29%)
Overfolded ears	A volte (5–29%)
Thickened helices	A volte (5–29%)

Abnormality of the integument

Tratto	Frequenza di osservazione
Excessive hair growth	Sempre
Absence of part of skin at birth	A volte (5–29%)
Deep-set nails	A volte (5–29%)
Fair hair	A volte (5–29%)
Fine hair	A volte (5–29%)
Partial absent skin pigmentation	A volte (5–29%)
Slow-growing hair	A volte (5–29%)
Small nail	A volte (5–29%)
Thick hair	A volte (5–29%)

Abnormality of the endocrine system

Tratto	Frequenza di osservazione
Delayed puberty	A volte (5–29%)
Elevated blood parathyroid hormone level	A volte (5–29%)
Hypogonadotropic hypogonadism	A volte (5–29%)
Parathyroid adenoma	A volte (5–29%)
Small pituitary gland	A volte (5–29%)
Underactive thyroid	A volte (5–29%)

Abnormality of the genitourinary system

Tratto	Frequenza di osservazione
Hypospadias	Spesso (30–79%)
Undescended testes	Spesso (30–79%)
Horseshoe kidney	A volte (5–29%)
Hydronephrosis	A volte (5–29%)
Increased calcium level in kidney	A volte (5–29%)
Kidney stone	A volte (5–29%)

Abnormality of prenatal development or birth

Tratto	Frequenza di osservazione
Caesarean section	Spesso (30–79%)
Premature birth	Spesso (30–79%)
High levels of amniotic fluid	A volte (5–29%)
Low levels of amniotic fluid	A volte (5–29%)

Abnormality of blood and blood-forming tissues

Tratto	Frequenza di osservazione
Bleeding in brain	A volte (5–29%)
Subarachnoid hemorrhage	A volte (5–29%)
Subdural hemorrhage	A volte (5–29%)

Constitutional symptom

Tratto	Frequenza di osservazione
Chronic pain	A volte (5–29%)

Growth abnormality

Tratto	Frequenza di osservazione
Birth weight > 90th percentile	A volte (5–29%)

Laboratory abnormality

Tratto	Frequenza di osservazione
High blood calcium levels	A volte (5–29%)

Con quale frequenza questo tratto si presenta tra le persone con una delle condizioni legate al gene, nella misura più alta riscontrata tra queste, secondo quanto registrato dall'Human Phenotype Ontology. Queste pagine descrivono tratti e la ricerca che li riguarda; non costituiscono una diagnosi, e per i sintomi il medico o il consulente genetico è la persona a cui rivolgersi.

Fonte dei dati

Human Phenotype Ontology, versione 2026-09-01: i tratti collegati a ZFX e la frequenza con cui ciascuno viene osservato. Per saperne di più visiti hpo.jax.org.

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