Traits

Traits linked to ROR2

ROR family WNT receptor 2

The Human Phenotype Ontology links 151 traits to ROR2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	Cât de frecvent apare
Short nose	Întotdeauna
Abnormal dentition	Foarte des (80–99%)
Downturned corners of mouth	Foarte des (80–99%)
Midface retrusion	Foarte des (80–99%)
Nasal tip, upturned	Foarte des (80–99%)
Open bite	Foarte des (80–99%)
Prominent forehead	Foarte des (80–99%)
Wide mouth	Foarte des (80–99%)
Wide nasal bridge	Foarte des (80–99%)
Abnormally small tongue	Des (30–79%)
Big calvaria	Des (30–79%)
Broad opening between the eyelids	Des (30–79%)
Cleft tongue	Des (30–79%)
Decreased number of teeth	Des (30–79%)
Depressed nasal bridge	Des (30–79%)
Downward slanting of the opening between the eyelids	Des (30–79%)
Eye folds	Des (30–79%)
Frontal bossing	Des (30–79%)
Gum enlargement	Des (30–79%)
Little lower jaw	Des (30–79%)
Long eyelashes	Des (30–79%)
Long philtrum	Des (30–79%)
Narrow palate	Des (30–79%)
Receding chin	Des (30–79%)
Short neck	Des (30–79%)
Tented mouth	Des (30–79%)
Thin red part of the upper lip	Des (30–79%)
Tongue tied	Des (30–79%)
Triangular mouth	Des (30–79%)
Upward slanting of the opening between the eyelids	Des (30–79%)
Abnormality of the palate	Uneori (5–29%)
Cleft of the mouth	Uneori (5–29%)
Exaggerated cupid's bow	Uneori (5–29%)
Extra teeth	Uneori (5–29%)
Failure of development of between one and six teeth	Uneori (5–29%)
Short philtrum	Uneori (5–29%)
Abnormally large tongue	Neînregistrat
Absent uvula	Neînregistrat
Delayed cranial suture closure	Neînregistrat
Delayed eruption of permanent teeth	Neînregistrat
Dental crowding	Neînregistrat
Flat face	Neînregistrat
Wider-than-typical soft spot of skull	Neînregistrat
Zygomatic flattening	Neînregistrat

Abnormality of limbs

Trait	Cât de frecvent apare
Disproportionately short middle portion of limb	Întotdeauna
Fused innermost and middle bones of little finger	Întotdeauna
Short fingers or toes	Întotdeauna
Absent/small outermost finger bone of the hand	Foarte des (80–99%)
Curvature of digit	Foarte des (80–99%)
Curvature of little finger	Foarte des (80–99%)
Short outermost finger bone	Foarte des (80–99%)
Short palm	Foarte des (80–99%)
Bilateral ulnar hypoplasia	Des (30–79%)
Bowing of outer large bone of the forearm	Des (30–79%)
Broad big toe	Des (30–79%)
Broad bone of big toe	Des (30–79%)
Broad thumb	Des (30–79%)
Dislocated radial head	Des (30–79%)
Elbow dislocation	Des (30–79%)
Limited pronation/supination of forearm	Des (30–79%)
Mesomelic arm shortening	Des (30–79%)
Single interphalangeal crease of fifth finger	Des (30–79%)
Underdeveloped outer large forearm bone	Des (30–79%)
Bilateral single transverse palmar creases	Uneori (5–29%)
Finger syndactyly	Uneori (5–29%)
Fused toes	Uneori (5–29%)
Fusion of wrist bones	Uneori (5–29%)
Gap between 1st and 2nd toes	Uneori (5–29%)
Hip dislocation	Uneori (5–29%)
Permanent flexion of the finger	Uneori (5–29%)
Single transverse palmar crease	Uneori (5–29%)
Split hand	Uneori (5–29%)
Webbed fingers	Uneori (5–29%)
Webbed fingers or toes	Uneori (5–29%)
Absent/small long bones of hand	Neînregistrat
Absent/small outermost bones of toe	Neînregistrat
Broad toe	Neînregistrat
Duplication of the outermost bone of hand	Neînregistrat
Joint contracture of the hand	Neînregistrat
Notched outermost bones of toes	Neînregistrat
Radial deviation of finger	Neînregistrat
Short digit	Neînregistrat
Short middle bone of finger	Neînregistrat
Short middle bone of the little finger	Neînregistrat
Small hand	Neînregistrat
Type B brachydactyly	Neînregistrat

Abnormality of the musculoskeletal system

Trait	Cât de frecvent apare
Missing part of vertebrae	Foarte des (80–99%)
Rib fusion	Foarte des (80–99%)
Vertebral segmentation defect	Foarte des (80–99%)
Double-Jointed	Des (30–79%)
Funnel chest	Des (30–79%)
Hunched back	Des (30–79%)
Scoliosis	Des (30–79%)
Abnormality of the hip bone	Uneori (5–29%)
Permanent flexion of the finger or toe	Uneori (5–29%)
Pigeon chest	Uneori (5–29%)
Delayed bone maturation	Neînregistrat
Missing ribs	Neînregistrat
Short long bone	Neînregistrat
Small sacrum	Neînregistrat
Thoracic hemivertebrae	Neînregistrat
Thoracolumbar scoliosis	Neînregistrat
Vertebral fusion	Neînregistrat

Abnormality of the genitourinary system

Trait	Cât de frecvent apare
Short penis	Întotdeauna
Underdeveloped penis	Foarte des (80–99%)
Hydronephrosis	Des (30–79%)
Increased calcium level in kidney	Des (30–79%)
Kidney stone	Des (30–79%)
Underdeveloped female external genitalia	Des (30–79%)
Underdeveloped inner lips	Des (30–79%)
Undescended testes	Des (30–79%)
Hypospadias	Uneori (5–29%)
Multicystic kidney dysplasia	Uneori (5–29%)
Small labia majora	Uneori (5–29%)
Small clitoris	Neînregistrat

Abnormality of the integument

Trait	Cât de frecvent apare
Small nail	Întotdeauna
Abnormal fingernail development	Des (30–79%)
Atypical nail growth	Des (30–79%)
Beauty mark	Uneori (5–29%)
Hair loss	Uneori (5–29%)
port-wine stain	Uneori (5–29%)
Spinal dimple	Uneori (5–29%)
Absent nails	Neînregistrat
Small fingernail	Neînregistrat

Abnormality of the cardiovascular system

Trait	Cât de frecvent apare
Abnormal aortic morphology	Uneori (5–29%)
Abnormal pulmonary valve morphology	Uneori (5–29%)
Abnormal tricuspid valve morphology	Uneori (5–29%)
Abnormality of the heart	Uneori (5–29%)
An opening in the wall separating the top two chambers of the heart	Uneori (5–29%)
Hole in heart wall separating two lower heart chambers	Uneori (5–29%)
Tetralogy of Fallot	Uneori (5–29%)
Right ventricular outlet tract obstruction	Neînregistrat

Abnormality of the ear

Trait	Cât de frecvent apare
Chronic infections of the middle ear	Des (30–79%)
Ears rotated toward back of head	Des (30–79%)
Hearing impairment	Des (30–79%)
Low-set ears	Des (30–79%)
Small ears	Uneori (5–29%)

Abnormality of the eye

Trait	Cât de frecvent apare
Wide-set eyes	Foarte des (80–99%)
Bulging eye	Des (30–79%)
Blue outer white part of eyeball	Uneori (5–29%)
Cross-eyed	Uneori (5–29%)
Drooping upper eyelid	Uneori (5–29%)

Abnormality of the digestive system

Trait	Cât de frecvent apare
Umbilical hernia	Des (30–79%)
Abnormal anus position	Uneori (5–29%)
Inguinal hernia	Uneori (5–29%)
Extra kidney	Neînregistrat

Abnormality of the nervous system

Trait	Cât de frecvent apare
Intellectual disability	Uneori (5–29%)
Global developmental delay	Neînregistrat

Growth abnormality

Trait	Cât de frecvent apare
Short stature	Întotdeauna
Disproportionate short-limb short stature	Foarte des (80–99%)

Abnormality of the immune system

Trait	Cât de frecvent apare
Recurrent respiratory infections	Uneori (5–29%)

Cât de frecvent apare în rândul persoanelor cu una dintre afecțiunile asociate genei, cel mai des întâlnit dintre acestea, conform Human Phenotype Ontology. Aceste pagini descriu trăsături și cercetările din spatele lor; ele nu reprezintă un diagnostic, iar pentru simptome trebuie să vă adresați medicului sau consilierului genetic.

De unde provin aceste informații

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ROR2 and how often each is seen. Find out more at hpo.jax.org.

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