Traits

Traits linked to ROR2

ROR family WNT receptor 2

The Human Phenotype Ontology links 151 traits to ROR2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	Kui sageli seda täheldatakse
Short nose	Alati
Abnormal dentition	Väga sageli (80–99%)
Downturned corners of mouth	Väga sageli (80–99%)
Midface retrusion	Väga sageli (80–99%)
Nasal tip, upturned	Väga sageli (80–99%)
Open bite	Väga sageli (80–99%)
Prominent forehead	Väga sageli (80–99%)
Wide mouth	Väga sageli (80–99%)
Wide nasal bridge	Väga sageli (80–99%)
Abnormally small tongue	Sageli (30–79%)
Big calvaria	Sageli (30–79%)
Broad opening between the eyelids	Sageli (30–79%)
Cleft tongue	Sageli (30–79%)
Decreased number of teeth	Sageli (30–79%)
Depressed nasal bridge	Sageli (30–79%)
Downward slanting of the opening between the eyelids	Sageli (30–79%)
Eye folds	Sageli (30–79%)
Frontal bossing	Sageli (30–79%)
Gum enlargement	Sageli (30–79%)
Little lower jaw	Sageli (30–79%)
Long eyelashes	Sageli (30–79%)
Long philtrum	Sageli (30–79%)
Narrow palate	Sageli (30–79%)
Receding chin	Sageli (30–79%)
Short neck	Sageli (30–79%)
Tented mouth	Sageli (30–79%)
Thin red part of the upper lip	Sageli (30–79%)
Tongue tied	Sageli (30–79%)
Triangular mouth	Sageli (30–79%)
Upward slanting of the opening between the eyelids	Sageli (30–79%)
Abnormality of the palate	Mõnikord (5–29%)
Cleft of the mouth	Mõnikord (5–29%)
Exaggerated cupid's bow	Mõnikord (5–29%)
Extra teeth	Mõnikord (5–29%)
Failure of development of between one and six teeth	Mõnikord (5–29%)
Short philtrum	Mõnikord (5–29%)
Abnormally large tongue	Pole registreeritud
Absent uvula	Pole registreeritud
Delayed cranial suture closure	Pole registreeritud
Delayed eruption of permanent teeth	Pole registreeritud
Dental crowding	Pole registreeritud
Flat face	Pole registreeritud
Wider-than-typical soft spot of skull	Pole registreeritud
Zygomatic flattening	Pole registreeritud

Abnormality of limbs

Trait	Kui sageli seda täheldatakse
Disproportionately short middle portion of limb	Alati
Fused innermost and middle bones of little finger	Alati
Short fingers or toes	Alati
Absent/small outermost finger bone of the hand	Väga sageli (80–99%)
Curvature of digit	Väga sageli (80–99%)
Curvature of little finger	Väga sageli (80–99%)
Short outermost finger bone	Väga sageli (80–99%)
Short palm	Väga sageli (80–99%)
Bilateral ulnar hypoplasia	Sageli (30–79%)
Bowing of outer large bone of the forearm	Sageli (30–79%)
Broad big toe	Sageli (30–79%)
Broad bone of big toe	Sageli (30–79%)
Broad thumb	Sageli (30–79%)
Dislocated radial head	Sageli (30–79%)
Elbow dislocation	Sageli (30–79%)
Limited pronation/supination of forearm	Sageli (30–79%)
Mesomelic arm shortening	Sageli (30–79%)
Single interphalangeal crease of fifth finger	Sageli (30–79%)
Underdeveloped outer large forearm bone	Sageli (30–79%)
Bilateral single transverse palmar creases	Mõnikord (5–29%)
Finger syndactyly	Mõnikord (5–29%)
Fused toes	Mõnikord (5–29%)
Fusion of wrist bones	Mõnikord (5–29%)
Gap between 1st and 2nd toes	Mõnikord (5–29%)
Hip dislocation	Mõnikord (5–29%)
Permanent flexion of the finger	Mõnikord (5–29%)
Single transverse palmar crease	Mõnikord (5–29%)
Split hand	Mõnikord (5–29%)
Webbed fingers	Mõnikord (5–29%)
Webbed fingers or toes	Mõnikord (5–29%)
Absent/small long bones of hand	Pole registreeritud
Absent/small outermost bones of toe	Pole registreeritud
Broad toe	Pole registreeritud
Duplication of the outermost bone of hand	Pole registreeritud
Joint contracture of the hand	Pole registreeritud
Notched outermost bones of toes	Pole registreeritud
Radial deviation of finger	Pole registreeritud
Short digit	Pole registreeritud
Short middle bone of finger	Pole registreeritud
Short middle bone of the little finger	Pole registreeritud
Small hand	Pole registreeritud
Type B brachydactyly	Pole registreeritud

Abnormality of the musculoskeletal system

Trait	Kui sageli seda täheldatakse
Missing part of vertebrae	Väga sageli (80–99%)
Rib fusion	Väga sageli (80–99%)
Vertebral segmentation defect	Väga sageli (80–99%)
Double-Jointed	Sageli (30–79%)
Funnel chest	Sageli (30–79%)
Hunched back	Sageli (30–79%)
Scoliosis	Sageli (30–79%)
Abnormality of the hip bone	Mõnikord (5–29%)
Permanent flexion of the finger or toe	Mõnikord (5–29%)
Pigeon chest	Mõnikord (5–29%)
Delayed bone maturation	Pole registreeritud
Missing ribs	Pole registreeritud
Short long bone	Pole registreeritud
Small sacrum	Pole registreeritud
Thoracic hemivertebrae	Pole registreeritud
Thoracolumbar scoliosis	Pole registreeritud
Vertebral fusion	Pole registreeritud

Abnormality of the genitourinary system

Trait	Kui sageli seda täheldatakse
Short penis	Alati
Underdeveloped penis	Väga sageli (80–99%)
Hydronephrosis	Sageli (30–79%)
Increased calcium level in kidney	Sageli (30–79%)
Kidney stone	Sageli (30–79%)
Underdeveloped female external genitalia	Sageli (30–79%)
Underdeveloped inner lips	Sageli (30–79%)
Undescended testes	Sageli (30–79%)
Hypospadias	Mõnikord (5–29%)
Multicystic kidney dysplasia	Mõnikord (5–29%)
Small labia majora	Mõnikord (5–29%)
Small clitoris	Pole registreeritud

Abnormality of the integument

Trait	Kui sageli seda täheldatakse
Small nail	Alati
Abnormal fingernail development	Sageli (30–79%)
Atypical nail growth	Sageli (30–79%)
Beauty mark	Mõnikord (5–29%)
Hair loss	Mõnikord (5–29%)
port-wine stain	Mõnikord (5–29%)
Spinal dimple	Mõnikord (5–29%)
Absent nails	Pole registreeritud
Small fingernail	Pole registreeritud

Abnormality of the cardiovascular system

Trait	Kui sageli seda täheldatakse
Abnormal aortic morphology	Mõnikord (5–29%)
Abnormal pulmonary valve morphology	Mõnikord (5–29%)
Abnormal tricuspid valve morphology	Mõnikord (5–29%)
Abnormality of the heart	Mõnikord (5–29%)
An opening in the wall separating the top two chambers of the heart	Mõnikord (5–29%)
Hole in heart wall separating two lower heart chambers	Mõnikord (5–29%)
Tetralogy of Fallot	Mõnikord (5–29%)
Right ventricular outlet tract obstruction	Pole registreeritud

Abnormality of the ear

Trait	Kui sageli seda täheldatakse
Chronic infections of the middle ear	Sageli (30–79%)
Ears rotated toward back of head	Sageli (30–79%)
Hearing impairment	Sageli (30–79%)
Low-set ears	Sageli (30–79%)
Small ears	Mõnikord (5–29%)

Abnormality of the eye

Trait	Kui sageli seda täheldatakse
Wide-set eyes	Väga sageli (80–99%)
Bulging eye	Sageli (30–79%)
Blue outer white part of eyeball	Mõnikord (5–29%)
Cross-eyed	Mõnikord (5–29%)
Drooping upper eyelid	Mõnikord (5–29%)

Abnormality of the digestive system

Trait	Kui sageli seda täheldatakse
Umbilical hernia	Sageli (30–79%)
Abnormal anus position	Mõnikord (5–29%)
Inguinal hernia	Mõnikord (5–29%)
Extra kidney	Pole registreeritud

Abnormality of the nervous system

Trait	Kui sageli seda täheldatakse
Intellectual disability	Mõnikord (5–29%)
Global developmental delay	Pole registreeritud

Growth abnormality

Trait	Kui sageli seda täheldatakse
Short stature	Alati
Disproportionate short-limb short stature	Väga sageli (80–99%)

Abnormality of the immune system

Trait	Kui sageli seda täheldatakse
Recurrent respiratory infections	Mõnikord (5–29%)

Kui sageli see esineb geenist tulenevate seisunditega inimeste seas, kõige sagedamini nende kõigi seas, nagu on märgitud Inimese fenotüübi ontoloogias. Need lehed kirjeldavad tunnuseid ja nende taga olevaid uuringuid; need ei ole diagnoos ning sümptomite kohta tuleks küsida arstilt või geneetilt nõustajalt.

Allikas

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ROR2 and how often each is seen. Find out more at hpo.jax.org.

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