Traits

Traits linked to ROR2

ROR family WNT receptor 2

The Human Phenotype Ontology links 151 traits to ROR2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Short nose	Always
Abnormal dentition	Very often (80–99%)
Downturned corners of mouth	Very often (80–99%)
Midface retrusion	Very often (80–99%)
Nasal tip, upturned	Very often (80–99%)
Open bite	Very often (80–99%)
Prominent forehead	Very often (80–99%)
Wide mouth	Very often (80–99%)
Wide nasal bridge	Very often (80–99%)
Abnormally small tongue	Often (30–79%)
Big calvaria	Often (30–79%)
Broad opening between the eyelids	Often (30–79%)
Cleft tongue	Often (30–79%)
Decreased number of teeth	Often (30–79%)
Depressed nasal bridge	Often (30–79%)
Downward slanting of the opening between the eyelids	Often (30–79%)
Eye folds	Often (30–79%)
Frontal bossing	Often (30–79%)
Gum enlargement	Often (30–79%)
Little lower jaw	Often (30–79%)
Long eyelashes	Often (30–79%)
Long philtrum	Often (30–79%)
Narrow palate	Often (30–79%)
Receding chin	Often (30–79%)
Short neck	Often (30–79%)
Tented mouth	Often (30–79%)
Thin red part of the upper lip	Often (30–79%)
Tongue tied	Often (30–79%)
Triangular mouth	Often (30–79%)
Upward slanting of the opening between the eyelids	Often (30–79%)
Abnormality of the palate	Sometimes (5–29%)
Cleft of the mouth	Sometimes (5–29%)
Exaggerated cupid's bow	Sometimes (5–29%)
Extra teeth	Sometimes (5–29%)
Failure of development of between one and six teeth	Sometimes (5–29%)
Short philtrum	Sometimes (5–29%)
Abnormally large tongue	Not recorded
Absent uvula	Not recorded
Delayed cranial suture closure	Not recorded
Delayed eruption of permanent teeth	Not recorded
Dental crowding	Not recorded
Flat face	Not recorded
Wider-than-typical soft spot of skull	Not recorded
Zygomatic flattening	Not recorded

Abnormality of limbs

Trait	How often it is seen
Disproportionately short middle portion of limb	Always
Fused innermost and middle bones of little finger	Always
Short fingers or toes	Always
Absent/small outermost finger bone of the hand	Very often (80–99%)
Curvature of digit	Very often (80–99%)
Curvature of little finger	Very often (80–99%)
Short outermost finger bone	Very often (80–99%)
Short palm	Very often (80–99%)
Bilateral ulnar hypoplasia	Often (30–79%)
Bowing of outer large bone of the forearm	Often (30–79%)
Broad big toe	Often (30–79%)
Broad bone of big toe	Often (30–79%)
Broad thumb	Often (30–79%)
Dislocated radial head	Often (30–79%)
Elbow dislocation	Often (30–79%)
Limited pronation/supination of forearm	Often (30–79%)
Mesomelic arm shortening	Often (30–79%)
Single interphalangeal crease of fifth finger	Often (30–79%)
Underdeveloped outer large forearm bone	Often (30–79%)
Bilateral single transverse palmar creases	Sometimes (5–29%)
Finger syndactyly	Sometimes (5–29%)
Fused toes	Sometimes (5–29%)
Fusion of wrist bones	Sometimes (5–29%)
Gap between 1st and 2nd toes	Sometimes (5–29%)
Hip dislocation	Sometimes (5–29%)
Permanent flexion of the finger	Sometimes (5–29%)
Single transverse palmar crease	Sometimes (5–29%)
Split hand	Sometimes (5–29%)
Webbed fingers	Sometimes (5–29%)
Webbed fingers or toes	Sometimes (5–29%)
Absent/small long bones of hand	Not recorded
Absent/small outermost bones of toe	Not recorded
Broad toe	Not recorded
Duplication of the outermost bone of hand	Not recorded
Joint contracture of the hand	Not recorded
Notched outermost bones of toes	Not recorded
Radial deviation of finger	Not recorded
Short digit	Not recorded
Short middle bone of finger	Not recorded
Short middle bone of the little finger	Not recorded
Small hand	Not recorded
Type B brachydactyly	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Missing part of vertebrae	Very often (80–99%)
Rib fusion	Very often (80–99%)
Vertebral segmentation defect	Very often (80–99%)
Double-Jointed	Often (30–79%)
Funnel chest	Often (30–79%)
Hunched back	Often (30–79%)
Scoliosis	Often (30–79%)
Abnormality of the hip bone	Sometimes (5–29%)
Permanent flexion of the finger or toe	Sometimes (5–29%)
Pigeon chest	Sometimes (5–29%)
Delayed bone maturation	Not recorded
Missing ribs	Not recorded
Short long bone	Not recorded
Small sacrum	Not recorded
Thoracic hemivertebrae	Not recorded
Thoracolumbar scoliosis	Not recorded
Vertebral fusion	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Short penis	Always
Underdeveloped penis	Very often (80–99%)
Hydronephrosis	Often (30–79%)
Increased calcium level in kidney	Often (30–79%)
Kidney stone	Often (30–79%)
Underdeveloped female external genitalia	Often (30–79%)
Underdeveloped inner lips	Often (30–79%)
Undescended testes	Often (30–79%)
Hypospadias	Sometimes (5–29%)
Multicystic kidney dysplasia	Sometimes (5–29%)
Small labia majora	Sometimes (5–29%)
Small clitoris	Not recorded

Abnormality of the integument

Trait	How often it is seen
Small nail	Always
Abnormal fingernail development	Often (30–79%)
Atypical nail growth	Often (30–79%)
Beauty mark	Sometimes (5–29%)
Hair loss	Sometimes (5–29%)
port-wine stain	Sometimes (5–29%)
Spinal dimple	Sometimes (5–29%)
Absent nails	Not recorded
Small fingernail	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormal aortic morphology	Sometimes (5–29%)
Abnormal pulmonary valve morphology	Sometimes (5–29%)
Abnormal tricuspid valve morphology	Sometimes (5–29%)
Abnormality of the heart	Sometimes (5–29%)
An opening in the wall separating the top two chambers of the heart	Sometimes (5–29%)
Hole in heart wall separating two lower heart chambers	Sometimes (5–29%)
Tetralogy of Fallot	Sometimes (5–29%)
Right ventricular outlet tract obstruction	Not recorded

Abnormality of the ear

Trait	How often it is seen
Chronic infections of the middle ear	Often (30–79%)
Ears rotated toward back of head	Often (30–79%)
Hearing impairment	Often (30–79%)
Low-set ears	Often (30–79%)
Small ears	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Wide-set eyes	Very often (80–99%)
Bulging eye	Often (30–79%)
Blue outer white part of eyeball	Sometimes (5–29%)
Cross-eyed	Sometimes (5–29%)
Drooping upper eyelid	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Umbilical hernia	Often (30–79%)
Abnormal anus position	Sometimes (5–29%)
Inguinal hernia	Sometimes (5–29%)
Extra kidney	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Intellectual disability	Sometimes (5–29%)
Global developmental delay	Not recorded

Growth abnormality

Trait	How often it is seen
Short stature	Always
Disproportionate short-limb short stature	Very often (80–99%)

Abnormality of the immune system

Trait	How often it is seen
Recurrent respiratory infections	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ROR2 and how often each is seen. Find out more at hpo.jax.org.

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