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Gene

CUL4B

cullin 4B

Summary

Cytogenetic location
Xq24
Coordinates
Chromosome X: 120,523,858–120,560,962 (GRCh38)
Exons
20 exons across 37.1 kb
Protein
895 amino acids
MANE Select transcript
ENST00000371322.11NM_001079872.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Intellectual Disability

      • One of 233 genes linked to it

        • ClinGen rates the link definitive
        • 3 GenCC submitters rate it definitive or strong

    How CUL4B is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome X, with a bracket where CUL4B sits. CUL4B and 23 genes near it on chromosome X, from 120,042,410 to 121,042,409.Chromosome XXq24p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28120.2 Mb120.4 Mb120.6 Mb120.8 Mb121 MbRHOXF2B: 120,072,264–120,077,748, reverse strandRHOXF2BRHOXF1: 120,109,049–120,245,290, reverse strandRHOXF1RHOXF2: 120,158,536–120,165,630, forward strandRHOXF2ZBTB33: 120,250,712–120,259,741, forward strandZBTB33TMEM255A: 120,258,650–120,311,556, reverse strandTMEM255AATP1B4: 120,362,085–120,383,249, forward strandATP1B4LAMP2: 120,426,148–120,469,365, reverse strandLAMP2CUL4B: 120,523,858–120,560,962, reverse strandCUL4BMCTS1: 120,594,010–120,621,159, forward strandMCTS1C1GALT1C1: 120,614,846–120,630,115, reverse strandC1GALT1C1CT47B1: 120,872,607–120,875,877, reverse strandCT47B1: 120,877,496–120,878,924, reverse strandCT47A12: 120,930,250–120,932,301, reverse strandCT47A12CT47A11: 120,933,840–120,937,158, reverse strandCT47A11CT47A10: 120,938,701–120,942,023, reverse strandCT47A10CT47A9: 120,943,561–120,946,883, reverse strandCT47A9CT47A8: 120,948,422–120,951,744, reverse strandCT47A7: 120,953,282–120,956,600, reverse strandCT47A6: 120,958,165–120,961,487, reverse strandCT47A5: 120,963,026–120,966,348, reverse strandCT47A4: 120,967,886–120,971,208, reverse strandCT47A3: 120,972,746–120,976,068, reverse strandCT47A2: 120,977,606–120,980,928, reverse strandCT47A1: 120,982,476–120,985,760, reverse strandDiagram of CUL4B: 20 exons on the reverse strand of chromosome XExon 19: 2 known disease-causing sitesExon 18: 3 known disease-causing sitesExon 17: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 10: 5 known disease-causing sitesExon 8: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 6: 3 known disease-causing sitesExon 3: 5 known disease-causing sitesExon 1: 3 known disease-causing sitesExon 20: 120,523,858–120,526,856, 2,999 basesExon 19: 120,530,102–120,530,254, 153 basesExon 18: 120,532,422–120,532,594, 173 basesExon 17: 120,534,481–120,534,586, 106 basesExon 16: 120,535,830–120,535,943, 114 basesExon 15: 120,536,927–120,537,034, 108 basesExon 14: 120,538,124–120,538,209, 86 basesExon 13: 120,538,660–120,538,770, 111 basesExon 12: 120,539,268–120,539,372, 105 basesExon 11: 120,540,370–120,540,562, 193 basesExon 10: 120,541,602–120,541,720, 119 basesExon 9: 120,542,966–120,543,033, 68 basesExon 8: 120,543,727–120,543,809, 83 basesExon 7: 120,544,114–120,544,203, 90 basesExon 6: 120,544,481–120,544,643, 163 basesExon 5: 120,545,444–120,545,517, 74 basesExon 4: 120,546,547–120,546,616, 70 basesExon 3: 120,547,136–120,547,239, 104 basesExon 2: 120,557,924–120,558,039, 116 basesExon 1: 120,560,083–120,560,962, 880 bases201816141210864215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 5.9 kb of the gene's 37.1 kb; 2,688 of those bases code for the protein.

    How a genome test reads CUL4B

    31

    positions in CUL4B where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 37.1 kb of CUL4B, introns included, not only the 5.9 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). CUL4B gene: cullin 4B. Retrieved 17 October 2026, from https://dantelabs.com/genes/cul4b

    Vancouver

    Dante Labs. CUL4B gene: cullin 4B [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cul4b

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