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Gene

FANCC

FA complementation group C

Summary

Cytogenetic location
9q22.32
Coordinates
Chromosome 9: 95,099,054–95,317,709 (GRCh38)
Exons
15 exons across 218.7 kb
Protein
558 amino acids
Inheritance
Autosomal recessive
Also known as
FAC, FA3
Previous symbols
FACC
MANE Select transcript
ENST00000289081.8NM_000136.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • DNA Repair Disease

    • Autosomal recessive

      A disease that has its basis in the disruption of DNA repair.

      • ClinGen rates the link definitive
      • 6 GenCC submitters rate it definitive or strong

  • Fanconi Anemia

    • Autosomal recessive

      Fanconi anemia (FA) is a hereditary DNA repair disorder characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors.

      • ClinGen rates the link definitive
      • 6 GenCC submitters rate it definitive or strong
      What knowing changes

      Hematopoietic stem cell transplantation using FA-specific reduced-intensity conditioning; androgens (oxymetholone) as bridge therapy; cancer surveillance for head/neck and gynecological malignancies; gene therapy in clinical trials

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How FANCC is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 9, with a bracket where FANCC sits. FANCC and 2 genes near it on chromosome 9, from 94,708,382 to 95,708,381.Chromosome 99q22.32p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.394.8 Mb95 Mb95.2 Mb95.4 Mb95.6 MbAOPEP: 94,726,604–95,151,793, forward strandAOPEPFANCC: 95,099,054–95,317,709, reverse strandFANCCPTCH1: 95,442,980–95,517,057, reverse strandPTCH1Diagram of FANCC: 15 exons on the reverse strand of chromosome 9Exon 15: 13 known disease-causing sitesExon 14: 15 known disease-causing sitesExon 13: 22 known disease-causing sitesExon 12: 8 known disease-causing sitesExon 11: 5 known disease-causing sitesExon 10: 12 known disease-causing sitesExon 9: 6 known disease-causing sitesExon 8: 18 known disease-causing sitesExon 7: 18 known disease-causing sitesExon 6: 11 known disease-causing sitesExon 5: 14 known disease-causing sitesExon 4: 20 known disease-causing sitesExon 3: 11 known disease-causing sitesExon 2: 27 known disease-causing sitesExon 15: 95,099,054–95,101,850, 2,797 basesExon 14: 95,107,066–95,107,269, 204 basesExon 13: 95,111,463–95,111,637, 175 basesExon 12: 95,114,629–95,114,710, 82 basesExon 11: 95,117,315–95,117,390, 76 basesExon 10: 95,125,086–95,125,185, 100 basesExon 9: 95,126,529–95,126,581, 53 basesExon 8: 95,135,346–95,135,502, 157 basesExon 7: 95,149,923–95,150,087, 165 basesExon 6: 95,171,079–95,171,143, 65 basesExon 5: 95,172,037–95,172,147, 111 basesExon 4: 95,240,649–95,240,743, 95 basesExon 3: 95,247,432–95,247,516, 85 basesExon 2: 95,249,127–95,249,369, 243 basesExon 1: 95,317,526–95,317,709, 184 bases15141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.6 kb of the gene's 218.7 kb; 1,677 of those bases code for the protein.

How a genome test reads FANCC

242

positions in FANCC where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 218.7 kb of FANCC, introns included, not only the 4.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FANCC gene: FA complementation group C. Retrieved 17 October 2026, from https://dantelabs.com/genes/fancc

Vancouver

Dante Labs. FANCC gene: FA complementation group C [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fancc

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