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Gene

UBE2T

ubiquitin conjugating enzyme E2 T

Summary

Cytogenetic location
1q32.1
Coordinates
Chromosome 1: 202,331,657–202,341,936 (GRCh38)
Exons
7 exons across 10.3 kb
Protein
197 amino acids
Inheritance
Autosomal recessive
Also known as
HSPC150, FANCT
MANE Select transcript
ENST00000646651.1NM_014176.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • DNA Repair Disease

    • Autosomal recessive

      A disease that has its basis in the disruption of DNA repair.

      • 3 GenCC submitters rate it definitive or strong

  • Fanconi Anemia

    • Autosomal recessive

      Fanconi anemia (FA) is a hereditary DNA repair disorder characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Hematopoietic stem cell transplantation using FA-specific reduced-intensity conditioning; androgens (oxymetholone) as bridge therapy; cancer surveillance for head/neck and gynecological malignancies; gene therapy in clinical trials

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How UBE2T is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where UBE2T sits. UBE2T and 13 genes near it on chromosome 1, from 201,836,797 to 202,836,796.Chromosome 11q32.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44202 Mb202.2 Mb202.4 Mb202.6 Mb202.8 MbIPO9: 201,829,104–201,884,291, forward strandIPO9SHISA4: 201,888,675–201,893,072, forward strandSHISA4LMOD1: 201,896,456–201,946,594, reverse strandLMOD1TIMM17A: 201,955,476–201,970,780, forward strandTIMM17ARNPEP: 201,982,372–202,006,175, forward strandRNPEPELF3: 202,007,945–202,017,183, forward strandELF3GPR37L1: 202,122,853–202,133,592, forward strandGPR37L1ARL8A: 202,133,404–202,144,755, reverse strandARL8APTPN7: 202,147,012–202,161,588, reverse strandPTPN7LGR6: 202,193,692–202,321,660, forward strandLGR6UBE2T: 202,331,657–202,341,936, reverse strandUBE2TPPP1R12B: 202,348,666–202,592,706, forward strandPPP1R12BSYT2: 202,590,596–202,710,526, reverse strandSYT2KDM5B: 202,724,495–202,808,526, reverse strandKDM5BDiagram of UBE2T: 7 exons on the reverse strand of chromosome 1Exon 4: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 7: 202,331,657–202,331,960, 304 basesExon 6: 202,333,010–202,333,093, 84 basesExon 5: 202,333,237–202,333,335, 99 basesExon 4: 202,333,450–202,333,555, 106 basesExon 3: 202,334,989–202,335,058, 70 basesExon 2: 202,335,646–202,335,818, 173 basesExon 1: 202,341,895–202,341,936, 42 bases76543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.9 kb of the gene's 10.3 kb; 594 of those bases code for the protein.

How a genome test reads UBE2T

2

positions in UBE2T where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 10.3 kb of UBE2T, introns included, not only the 0.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). UBE2T gene: ubiquitin conjugating enzyme E2 T. Retrieved 16 October 2026, from https://dantelabs.com/genes/ube2t

Vancouver

Dante Labs. UBE2T gene: ubiquitin conjugating enzyme E2 T [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ube2t

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