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Gene

RAD51

RAD51 recombinase

Summary

Cytogenetic location
15q15.1
Coordinates
Chromosome 15: 40,695,174–40,732,340 (GRCh38)
Exons
10 exons across 37.2 kb
Protein
339 amino acids
Inheritance
Autosomal recessive
Also known as
HsRad51, HsT16930, BRCC5, FANCR
Previous symbols
RAD51A, RECA
MANE Select transcript
ENST00000267868.8NM_002875.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • DNA Repair Disease

    • Autosomal recessive

      A disease that has its basis in the disruption of DNA repair.

      • 2 GenCC submitters rate it definitive or strong

  • Fanconi Anemia

    • Autosomal recessive

      Fanconi anemia (FA) is a hereditary DNA repair disorder characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Hematopoietic stem cell transplantation using FA-specific reduced-intensity conditioning; androgens (oxymetholone) as bridge therapy; cancer surveillance for head/neck and gynecological malignancies; gene therapy in clinical trials

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How RAD51 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where RAD51 sits. RAD51 and 29 genes near it on chromosome 15, from 40,213,757 to 41,213,756.Chromosome 1515q15.1p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.340.4 Mb40.6 Mb40.8 Mb41 Mb41.2 MbBUB1B: 40,160,984–40,221,137, forward strandBUB1BPAK6: 40,217,428–40,277,489, forward strandPAK6BUB1B-PAK6: 40,218,500–40,264,890, forward strandBUB1B-PAK6PLCB2: 40,278,176–40,307,965, reverse strandPLCB2ANKRD63: 40,278,372–40,283,064, reverse strandANKRD63INAFM2: 40,323,692–40,326,715, forward strandINAFM2CCDC9B: 40,331,452–40,340,954, reverse strandCCDC9BPHGR1: 40,351,025–40,357,622, forward strandPHGR1DISP2: 40,358,219–40,378,621, forward strandDISP2KNSTRN: 40,382,721–40,395,659, forward strandKNSTRNIVD: 40,405,485–40,435,956, forward strandIVDBAHD1: 40,436,611–40,468,242, forward strandBAHD1CHST14: 40,470,984–40,473,158, forward strandCHST14CCDC32: 40,519,519–40,565,054, reverse strandCCDC32RPUSD2: 40,569,289–40,575,171, forward strandRPUSD2KNL1: 40,594,002–40,664,342, forward strandKNL1RAD51: 40,695,174–40,732,340, forward strandRAD51RMDN3: 40,720,655–40,755,851, reverse strandRMDN3GCHFR: 40,764,043–40,767,872, forward strandGCHFRDNAJC17: 40,765,161–40,807,498, reverse strandDNAJC17C15orf62: 40,769,980–40,772,449, forward strandC15orf62ZFYVE19: 40,807,086–40,815,084, forward strandZFYVE19PPP1R14D: 40,814,731–40,829,395, reverse strandSPINT1: 40,843,513–40,860,274, forward strandSPINT1RHOV: 40,872,214–40,874,245, reverse strandRHOVVPS18: 40,894,412–40,903,975, forward strandVPS18DLL4: 40,929,333–40,939,081, forward strandDLL4CHAC1: 40,952,962–40,957,478, forward strandCHAC1INO80: 40,978,880–41,116,568, reverse strandINO80EXD1: 41,182,725–41,230,757, reverse strandEXD1Diagram of RAD51: 10 exons on the forward strand of chromosome 15Exon 7: 1 known disease-causing siteExon 8: 3 known disease-causing sitesExon 9: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 1: 40,695,174–40,695,425, 252 basesExon 2: 40,698,757–40,698,845, 89 basesExon 3: 40,701,064–40,701,201, 138 basesExon 4: 40,706,177–40,706,294, 118 basesExon 5: 40,709,025–40,709,116, 92 basesExon 6: 40,718,805–40,718,899, 95 basesExon 7: 40,728,711–40,728,824, 114 basesExon 8: 40,729,505–40,729,634, 130 basesExon 9: 40,729,853–40,729,974, 122 basesExon 10: 40,731,055–40,732,340, 1,286 bases12468105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 37.2 kb; 1,020 of those bases code for the protein.

How a genome test reads RAD51

6

positions in RAD51 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 37.2 kb of RAD51, introns included, not only the 2.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RAD51 gene: RAD51 recombinase. Retrieved 16 October 2026, from https://dantelabs.com/genes/rad51

Vancouver

Dante Labs. RAD51 gene: RAD51 recombinase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rad51

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