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Gene

GNA11

G protein subunit alpha 11

Summary

Cytogenetic location
19p13.3
Coordinates
Chromosome 19: 3,094,362–3,123,999 (GRCh38)
Exons
7 exons across 29.6 kb
Protein
359 amino acids
Inheritance
Autosomal dominant
Also known as
FBH, FBH2, FHH2
Previous symbols
HHC2
MANE Select transcript
ENST00000078429.9NM_002067.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Inherited Parathyroid & Calcium-Sensing Disorders

    • Familial hypocalciuric hypercalcaemiaAutosomal dominant

      Lifelong, usually harmless mildly high blood calcium with low urine calcium, caused by reduced calcium sensing (CASR, GNA11, AP2S1).

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Recognising it avoids unnecessary parathyroid surgery, which does not cure it.

    • Familial hypoparathyroidism

      Low parathyroid hormone and low blood calcium, including autosomal dominant hypocalcaemia caused by overactive calcium sensing.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      In autosomal dominant hypocalcaemia, standard calcium and vitamin D treatment can worsen kidney calcium loss, so treatment needs specialist adjustment.

  • Thyroid Cancer

    • Parathyroid Gland Disorder

      A disease involving the parathyroid gland.

      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How GNA11 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where GNA11 sits. GNA11 and 28 genes near it on chromosome 19, from 2,609,181 to 3,609,180.Chromosome 1919p13.3p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.432.8 Mb3 Mb3.2 Mb3.4 Mb3.6 MbGNG7: 2,511,214–2,702,727, reverse strandGNG7DIRAS1: 2,714,566–2,721,438, reverse strandDIRAS1: 2,717,769–2,740,048, reverse strandSLC39A3: 2,732,204–2,740,071, reverse strandSLC39A3SGTA: 2,754,711–2,783,390, reverse strandSGTATHOP1: 2,785,444–2,815,807, forward strandTHOP1ZNF554: 2,819,853–2,836,735, forward strandZNF554ZNF555: 2,841,437–2,860,471, forward strandZNF555ZNF556: 2,867,292–2,883,445, forward strandZNF556ZNF57: 2,900,914–2,919,102, forward strandZNF57ZNF77: 2,931,137–2,944,971, reverse strandZNF77TLE6: 2,977,538–2,995,179, forward strandTLE6TLE2: 2,997,632–3,047,635, reverse strandTLE2TLE5: 3,052,908–3,063,112, reverse strandTLE5GNA11: 3,094,362–3,123,999, forward strandGNA11GNA15: 3,136,027–3,163,749, forward strandGNA15S1PR4: 3,172,346–3,180,332, forward strandS1PR4NCLN: 3,185,563–3,209,575, forward strandNCLNCELF5: 3,224,636–3,297,076, forward strandCELF5NFIC: 3,314,403–3,469,217, forward strandNFICSMIM24: 3,473,986–3,480,557, reverse strandSMIM24SMIM44: 3,482,110–3,483,441, reverse strandSMIM44DOHH: 3,490,821–3,507,203, reverse strandDOHHFZR1: 3,506,270–3,538,334, forward strandFZR1MFSD12: 3,538,261–3,574,290, reverse strandMFSD12TEKTIP1: 3,539,169–3,544,030, forward strandHMG20B: 3,572,692–3,579,088, forward strandHMG20BGIPC3: 3,585,474–3,593,541, forward strandGIPC3TBXA2R: 3,594,506–3,606,900, reverse strandTBXA2RDiagram of GNA11: 7 exons on the forward strand of chromosome 19Exon 2: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 4: 3 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 1: 3,094,362–3,094,787, 426 basesExon 2: 3,110,149–3,110,333, 185 basesExon 3: 3,113,330–3,113,484, 155 basesExon 4: 3,114,944–3,115,072, 129 basesExon 5: 3,118,924–3,119,053, 130 basesExon 6: 3,119,206–3,119,359, 154 basesExon 7: 3,120,989–3,123,999, 3,011 bases124675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.2 kb of the gene's 29.6 kb; 1,080 of those bases code for the protein.

How a genome test reads GNA11

8

positions in GNA11 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 29.6 kb of GNA11, introns included, not only the 4.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GNA11 gene: G protein subunit alpha 11. Retrieved 17 October 2026, from https://dantelabs.com/genes/gna11

Vancouver

Dante Labs. GNA11 gene: G protein subunit alpha 11 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gna11

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