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Gene

DYNC2H1

dynein cytoplasmic 2 heavy chain 1

Summary

Cytogenetic location
11q22.3
Coordinates
Chromosome 11: 103,109,426–103,479,863 (GRCh38)
Exons
89 exons across 370.4 kb
Protein
4,307 amino acids
Also known as
hdhc11, DHC2, DHC1b, DYH1B
Previous symbols
DNCH2
MANE Select transcript
ENST00000375735.7NM_001377.3
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads DYNC2H1 yet. The test sequences your whole genome, so your data includes it all the same.

How DYNC2H1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where DYNC2H1 sits. DYNC2H1 and 6 genes near it on chromosome 11, from 102,738,988 to 103,850,301.Chromosome 1111q22.3p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25102.8 Mb103 Mb103.2 Mb103.4 Mb103.6 Mb103.8 MbMMP10: 102,770,502–102,780,628, reverse strandMMP10MMP1: 102,789,401–102,798,167, reverse strandMMP1MMP3: 102,835,801–102,843,615, reverse strandMMP3MMP12: 102,862,734–102,874,990, reverse strandMMP12MMP13: 102,942,994–102,955,740, reverse strandMMP13DCUN1D5: 103,050,686–103,092,203, reverse strandDCUN1D5DYNC2H1: 103,109,426–103,479,863, forward strandDYNC2H1Diagram of DYNC2H1: 89 exons on the forward strand of chromosome 11Exon 1: 2 known disease-causing sitesExon 2: 7 known disease-causing sitesExon 3: 6 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 5: 6 known disease-causing sitesExon 6: 9 known disease-causing sitesExon 7: 6 known disease-causing sitesExon 8: 7 known disease-causing sitesExon 9: 4 known disease-causing sitesExon 10: 7 known disease-causing sitesExon 11: 9 known disease-causing sitesExon 12: 6 known disease-causing sitesExon 13: 3 known disease-causing sitesExon 14: 9 known disease-causing sitesExon 15: 3 known disease-causing sitesExon 16: 8 known disease-causing sitesExon 17: 10 known disease-causing sitesExon 18: 6 known disease-causing sitesExon 19: 4 known disease-causing sitesExon 20: 3 known disease-causing sitesExon 21: 8 known disease-causing sitesExon 22: 12 known disease-causing sitesExon 23: 6 known disease-causing sitesExon 24: 5 known disease-causing sitesExon 25: 5 known disease-causing sitesExon 26: 19 known disease-causing sitesExon 27: 5 known disease-causing sitesExon 28: 6 known disease-causing sitesExon 29: 5 known disease-causing sitesExon 30: 8 known disease-causing sitesExon 31: 6 known disease-causing sitesExon 32: 8 known disease-causing sitesExon 33: 5 known disease-causing sitesExon 34: 8 known disease-causing sitesExon 35: 8 known disease-causing sitesExon 36: 4 known disease-causing sitesExon 37: 4 known disease-causing sitesExon 38: 24 known disease-causing sitesExon 39: 8 known disease-causing sitesExon 40: 7 known disease-causing sitesExon 41: 3 known disease-causing sitesExon 42: 16 known disease-causing sitesExon 43: 12 known disease-causing sitesExon 44: 5 known disease-causing sitesExon 45: 6 known disease-causing sitesExon 46: 5 known disease-causing sitesExon 47: 7 known disease-causing sitesExon 48: 6 known disease-causing sitesExon 49: 15 known disease-causing sitesExon 50: 6 known disease-causing sitesExon 51: 6 known disease-causing sitesExon 52: 3 known disease-causing sitesExon 53: 7 known disease-causing sitesExon 54: 9 known disease-causing sitesExon 55: 7 known disease-causing sitesExon 56: 7 known disease-causing sitesExon 57: 6 known disease-causing sitesExon 58: 3 known disease-causing sitesExon 59: 4 known disease-causing sitesExon 60: 4 known disease-causing sitesExon 61: 7 known disease-causing sitesExon 62: 2 known disease-causing sitesExon 63: 2 known disease-causing sitesExon 64: 6 known disease-causing sitesExon 65: 5 known disease-causing sitesExon 66: 13 known disease-causing sitesExon 67: 7 known disease-causing sitesExon 68: 5 known disease-causing sitesExon 69: 5 known disease-causing sitesExon 70: 5 known disease-causing sitesExon 71: 2 known disease-causing sitesExon 72: 4 known disease-causing sitesExon 73: 3 known disease-causing sitesExon 74: 4 known disease-causing sitesExon 75: 1 known disease-causing siteExon 76: 5 known disease-causing sitesExon 77: 5 known disease-causing sitesExon 78: 7 known disease-causing sitesExon 79: 6 known disease-causing sitesExon 80: 6 known disease-causing sitesExon 81: 6 known disease-causing sitesExon 83: 5 known disease-causing sitesExon 84: 5 known disease-causing sitesExon 85: 9 known disease-causing sitesExon 86: 9 known disease-causing sitesExon 87: 3 known disease-causing sitesExon 88: 4 known disease-causing sitesExon 89: 5 known disease-causing sitesExon 1: 103,109,426–103,109,769, 344 basesExon 2: 103,113,537–103,113,707, 171 basesExon 3: 103,114,103–103,114,238, 136 basesExon 4: 103,115,177–103,115,295, 119 basesExon 5: 103,116,570–103,116,714, 145 basesExon 6: 103,117,631–103,117,863, 233 basesExon 7: 103,120,447–103,120,581, 135 basesExon 8: 103,120,689–103,120,802, 114 basesExon 9: 103,120,925–103,121,036, 112 basesExon 10: 103,121,372–103,121,496, 125 basesExon 11: 103,122,825–103,123,000, 176 basesExon 12: 103,125,100–103,125,295, 196 basesExon 13: 103,128,910–103,129,005, 96 basesExon 14: 103,133,555–103,133,707, 153 basesExon 15: 103,134,321–103,134,419, 99 basesExon 16: 103,135,495–103,135,634, 140 basesExon 17: 103,135,720–103,135,948, 229 basesExon 18: 103,143,268–103,143,395, 128 basesExon 19: 103,147,772–103,147,887, 116 basesExon 20: 103,148,490–103,148,617, 128 basesExon 21: 103,152,136–103,152,285, 150 basesExon 22: 103,153,303–103,153,508, 206 basesExon 23: 103,154,451–103,154,606, 156 basesExon 24: 103,154,695–103,154,809, 115 basesExon 25: 103,155,331–103,155,501, 171 basesExon 26: 103,156,388–103,156,770, 383 basesExon 27: 103,158,677–103,158,809, 133 basesExon 28: 103,158,910–103,159,027, 118 basesExon 29: 103,160,932–103,161,044, 113 basesExon 30: 103,163,028–103,163,147, 120 basesExon 31: 103,165,898–103,166,048, 151 basesExon 32: 103,168,755–103,168,960, 206 basesExon 33: 103,170,108–103,170,290, 183 basesExon 34: 103,170,886–103,171,068, 183 basesExon 35: 103,173,082–103,173,305, 224 basesExon 36: 103,174,055–103,174,170, 116 basesExon 37: 103,176,235–103,176,434, 200 basesExon 38: 103,177,556–103,177,820, 265 basesExon 39: 103,179,026–103,179,233, 208 basesExon 40: 103,181,757–103,181,886, 130 basesExon 41: 103,184,896–103,185,051, 156 basesExon 42: 103,186,242–103,186,501, 260 basesExon 43: 103,187,340–103,187,586, 247 basesExon 44: 103,188,497–103,188,648, 152 basesExon 45: 103,189,672–103,189,816, 145 basesExon 46: 103,191,517–103,191,619, 103 basesExon 47: 103,192,097–103,192,264, 168 basesExon 48: 103,197,933–103,198,063, 131 basesExon 49: 103,199,228–103,199,476, 249 basesExon 50: 103,200,046–103,200,154, 109 basesExon 51: 103,203,663–103,203,776, 114 basesExon 52: 103,204,822–103,204,964, 143 basesExon 53: 103,209,876–103,209,960, 85 basesExon 54: 103,211,789–103,211,943, 155 basesExon 55: 103,215,721–103,215,858, 138 basesExon 56: 103,219,915–103,220,028, 114 basesExon 57: 103,220,623–103,220,783, 161 basesExon 58: 103,222,030–103,222,153, 124 basesExon 59: 103,222,965–103,223,086, 122 basesExon 60: 103,231,260–103,231,346, 87 basesExon 61: 103,234,034–103,234,160, 127 basesExon 62: 103,235,672–103,235,813, 142 basesExon 63: 103,236,430–103,236,539, 110 basesExon 64: 103,243,693–103,243,791, 99 basesExon 65: 103,245,251–103,245,374, 124 basesExon 66: 103,253,285–103,253,448, 164 basesExon 67: 103,255,415–103,255,534, 120 basesExon 68: 103,256,106–103,256,240, 135 basesExon 69: 103,257,608–103,257,751, 144 basesExon 70: 103,259,888–103,259,977, 90 basesExon 71: 103,280,348–103,280,413, 66 basesExon 72: 103,282,179–103,282,229, 51 basesExon 73: 103,283,008–103,283,085, 78 basesExon 74: 103,286,255–103,286,386, 132 basesExon 75: 103,287,533–103,287,605, 73 basesExon 76: 103,303,093–103,303,253, 161 basesExon 77: 103,304,595–103,304,720, 126 basesExon 78: 103,307,721–103,307,831, 111 basesExon 79: 103,311,878–103,312,033, 156 basesExon 80: 103,316,545–103,316,620, 76 basesExon 81: 103,321,029–103,321,237, 209 basesExon 82: 103,323,886–103,323,990, 105 basesExon 83: 103,358,243–103,358,359, 117 basesExon 84: 103,399,663–103,399,872, 210 basesExon 85: 103,435,943–103,436,032, 90 basesExon 86: 103,455,186–103,455,295, 110 basesExon 87: 103,456,275–103,456,356, 82 basesExon 88: 103,468,589–103,468,705, 117 basesExon 89: 103,479,095–103,479,863, 769 bases11020304050607080895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 13.7 kb of the gene's 370.4 kb; 12,924 of those bases code for the protein.

How a genome test reads DYNC2H1

676

positions in DYNC2H1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 370.4 kb of DYNC2H1, introns included, not only the 13.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DYNC2H1 gene: dynein cytoplasmic 2 heavy chain 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/dync2h1

Vancouver

Dante Labs. DYNC2H1 gene: dynein cytoplasmic 2 heavy chain 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dync2h1

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