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Gene

RAD51C

RAD51 paralog C

Summary

Cytogenetic location
17q22
Coordinates
Chromosome 17: 58,692,602–58,735,611 (GRCh38)
Exons
9 exons across 43 kb
Protein
376 amino acids
Inheritance
Autosomal dominant Autosomal recessive
Also known as
RAD51L2, FANCO
MANE Select transcript
ENST00000337432.9NM_058216.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • DNA Repair Disease

    • Autosomal recessive

      A disease that has its basis in the disruption of DNA repair.

      • 3 GenCC submitters rate it definitive or strong

  • Fanconi Anemia

    • Autosomal recessive

      Fanconi anemia (FA) is a hereditary DNA repair disorder characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Hematopoietic stem cell transplantation using FA-specific reduced-intensity conditioning; androgens (oxymetholone) as bridge therapy; cancer surveillance for head/neck and gynecological malignancies; gene therapy in clinical trials

  • Breast and Ovarian Cancer Genes Beyond BRCA1/2

    • RAD51C-related cancer predispositionAutosomal dominant

      Variants in RAD51C that raise the risk of ovarian cancer and, to a lesser degree, breast cancer.

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Removal of the ovaries and fallopian tubes is often considered from the mid-40s to reduce ovarian cancer risk.

    • Familial breast-ovarian cancer susceptibility 3 (RAD51C)Autosomal dominant

      RAD51C-related susceptibility to breast and ovarian cancer.

      • 2 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.
Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How RAD51C is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where RAD51C sits. RAD51C and 18 genes near it on chromosome 17, from 58,214,107 to 59,214,106.Chromosome 1717q22p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.358.4 Mb58.6 Mb58.8 Mb59 Mb59.2 MbMKS1: 58,205,350–58,219,605, reverse strandMKS1LPO: 58,218,548–58,268,518, forward strandLPOMPO: 58,269,855–58,280,935, reverse strandMPOTSPOAP1: 58,301,228–58,328,823, reverse strandTSPOAP1SUPT4H1: 58,345,175–58,353,099, reverse strandSUPT4H1: 58,345,206–58,417,595, reverse strandRNF43: 58,353,671–58,417,735, reverse strandRNF43HSF5: 58,420,167–58,488,408, reverse strandHSF5MTMR4: 58,489,529–58,517,905, reverse strandMTMR4SEPTIN4: 58,519,969–58,544,368, reverse strandSEPTIN4TEX14: 58,556,678–58,692,055, reverse strandTEX14IGBP1C: 58,660,424–58,692,055, reverse strandIGBP1CRAD51C: 58,692,602–58,735,611, forward strandRAD51CPPM1E: 58,755,851–58,985,179, forward strandPPM1ETRIM37: 58,982,633–59,106,921, reverse strandTRIM37SKA2: 59,109,857–59,155,260, reverse strandSKA2PRR11: 59,155,732–59,206,709, forward strandPRR11: 59,197,566–59,215,226, forward strandSMG8: 59,209,400–59,215,249, forward strandSMG8Diagram of RAD51C: 9 exons on the forward strand of chromosome 17Exon 1: 27 known disease-causing sitesExon 2: 71 known disease-causing sitesExon 3: 50 known disease-causing sitesExon 4: 27 known disease-causing sitesExon 5: 21 known disease-causing sitesExon 6: 13 known disease-causing sitesExon 7: 17 known disease-causing sitesExon 8: 12 known disease-causing sitesExon 9: 5 known disease-causing sitesExon 1: 58,692,602–58,692,788, 187 basesExon 2: 58,694,931–58,695,189, 259 basesExon 3: 58,696,693–58,696,859, 167 basesExon 4: 58,703,196–58,703,329, 134 basesExon 5: 58,709,859–58,709,990, 132 basesExon 6: 58,720,746–58,720,812, 67 basesExon 7: 58,724,040–58,724,100, 61 basesExon 8: 58,732,484–58,732,544, 61 basesExon 9: 58,734,118–58,735,611, 1,494 bases1234567895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.6 kb of the gene's 43 kb; 1,131 of those bases code for the protein.

How a genome test reads RAD51C

296

positions in RAD51C where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 43 kb of RAD51C, introns included, not only the 2.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RAD51C gene: RAD51 paralog C. Retrieved 17 October 2026, from https://dantelabs.com/genes/rad51c

Vancouver

Dante Labs. RAD51C gene: RAD51 paralog C [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rad51c

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