Skip to content
Use your HSA or FSA funds
Sequence your genome (opens in a new tab)

Gene

BRD4

bromodomain containing 4

Summary

Cytogenetic location
19p13.12
Coordinates
Chromosome 19: 15,235,519–15,332,539 (GRCh38)
Exons
20 exons across 97 kb
Protein
1,362 amino acids
Also known as
HUNKI, MCAP, CAP, HUNK1, FSHRG4
MANE Select transcript
ENST00000679869.1NM_001379291.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

  • Cornelia de Lange Syndrome

    • A developmental disorder caused by variants in NIPBL, SMC1A, SMC3, RAD21, HDAC8 or BRD4, with a wide range of severity.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Diagnosis guides monitoring for associated problems such as reflux, heart defects, hearing and vision issues.

Broader groupings

  • Intellectual Disability

    • One of 233 genes linked to it

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong

How BRD4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where BRD4 sits. BRD4 and 24 genes near it on chromosome 19, from 14,784,029 to 15,784,028.Chromosome 1919p13.12p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4314.8 Mb15 Mb15.2 Mb15.4 Mb15.6 MbOR7C1: 14,789,260–14,835,376, reverse strandOR7C1OR7A5: 14,826,241–14,835,285, reverse strandOR7A5OR7A10: 14,840,466–14,848,922, reverse strandOR7A10OR7A17: 14,878,203–14,886,132, reverse strandOR7A17OR7C2: 14,941,489–14,942,448, forward strandOR7C2SLC1A6: 14,950,024–15,022,990, reverse strandSLC1A6TEKTL1: 15,010,726–15,023,276, forward strandTEKTL1CASP14: 15,049,480–15,058,293, forward strandCASP14OR1I1: 15,082,211–15,092,970, forward strandOR1I1SYDE1: 15,107,296–15,114,988, forward strandSYDE1HACL2: 15,114,974–15,125,801, reverse strandHACL2NOTCH3: 15,159,038–15,201,004, reverse strandNOTCH3EPHX3: 15,226,899–15,233,591, reverse strandEPHX3BRD4: 15,235,519–15,332,539, reverse strandBRD4AKAP8: 15,353,385–15,379,862, reverse strandAKAP8AKAP8L: 15,380,046–15,419,141, reverse strandAKAP8LWIZ: 15,419,978–15,450,038, reverse strandWIZRASAL3: 15,451,624–15,464,583, reverse strandRASAL3PGLYRP2: 15,468,625–15,498,956, reverse strandPGLYRP2CYP4F22: 15,508,477–15,552,317, forward strandCYP4F22CYP4F8: 15,615,218–15,630,639, forward strandCYP4F8CYP4F3: 15,640,795–15,662,825, forward strandCYP4F3CYP4F12: 15,673,018–15,698,819, forward strandCYP4F12OR10H2: 15,728,024–15,729,052, forward strandOR10H2OR10H3: 15,737,985–15,742,343, forward strandOR10H3Diagram of BRD4: 20 exons on the reverse strand of chromosome 19Exon 18: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 14: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 20: 15,235,519–15,238,445, 2,927 basesExon 19: 15,238,743–15,238,980, 238 basesExon 18: 15,239,059–15,239,264, 206 basesExon 17: 15,239,392–15,239,522, 131 basesExon 16: 15,239,659–15,239,821, 163 basesExon 15: 15,239,910–15,240,022, 113 basesExon 14: 15,242,900–15,243,487, 588 basesExon 13: 15,244,231–15,244,600, 370 basesExon 12: 15,244,710–15,244,762, 53 basesExon 11: 15,254,152–15,254,262, 111 basesExon 10: 15,255,297–15,255,592, 296 basesExon 9: 15,256,064–15,256,263, 200 basesExon 8: 15,256,964–15,257,173, 210 basesExon 7: 15,263,420–15,263,548, 129 basesExon 6: 15,264,404–15,264,766, 363 basesExon 5: 15,265,354–15,265,643, 290 basesExon 4: 15,267,416–15,267,551, 136 basesExon 3: 15,268,905–15,269,042, 138 basesExon 2: 15,272,815–15,273,133, 319 basesExon 1: 15,332,290–15,332,539, 250 bases201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.2 kb of the gene's 97 kb; 4,089 of those bases code for the protein.

How a genome test reads BRD4

14

positions in BRD4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 97 kb of BRD4, introns included, not only the 7.2 kb of exons.

Genes linked to the same conditions

Traits linked to BRD4

The Human Phenotype Ontology lists these as features of the rare conditions BRD4 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). BRD4 gene: bromodomain containing 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/brd4

Vancouver

Dante Labs. BRD4 gene: bromodomain containing 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/brd4

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test