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Gene

XRCC2

X-ray repair cross complementing 2

Summary

Cytogenetic location
7q36.1
Coordinates
Chromosome 7: 152,644,776–152,676,141 (GRCh38)
Exons
3 exons across 31.4 kb
Protein
280 amino acids
Also known as
FANCU
MANE Select transcript
ENST00000359321.2NM_005431.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads XRCC2 yet. The test sequences your whole genome, so your data includes it all the same.

How XRCC2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where XRCC2 sits. XRCC2 and 2 genes near it on chromosome 7, from 152,160,459 to 153,160,458.Chromosome 77q36.1p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3152.2 Mb152.4 Mb152.6 Mb152.8 Mb153 MbKMT2C: 152,134,922–152,436,656, reverse strandKMT2CXRCC2: 152,644,776–152,676,141, reverse strandXRCC2ACTR3B: 152,759,731–152,855,378, forward strandACTR3BDiagram of XRCC2: 3 exons on the reverse strand of chromosome 7Exon 3: 4 known disease-causing sitesExon 3: 152,644,776–152,649,363, 4,588 basesExon 2: 152,660,701–152,660,782, 82 basesExon 1: 152,676,041–152,676,141, 101 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.8 kb of the gene's 31.4 kb; 843 of those bases code for the protein.

How a genome test reads XRCC2

4

positions in XRCC2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 31.4 kb of XRCC2, introns included, not only the 4.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). XRCC2 gene: X-ray repair cross complementing 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/xrcc2

Vancouver

Dante Labs. XRCC2 gene: X-ray repair cross complementing 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/xrcc2

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