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Gene

TCTN3

tectonic family member 3

Summary

Cytogenetic location
10q24.1
Coordinates
Chromosome 10: 95,663,401–95,693,927 (GRCh38)
Exons
14 exons across 30.5 kb
Protein
607 amino acids
Also known as
DKFZP564D116, TECT3, JBTS18
Previous symbols
C10orf61
MANE Select transcript
ENST00000371217.10NM_015631.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Joubert Syndrome And Related Disorders

    • Joubert Syndrome

      A ciliopathy defined by a malformation of the cerebellum and brainstem (the molar tooth sign), with low muscle tone, developmental delay and abnormal eye movements, sometimes with kidney, liver or eye involvement.

      • 2 GenCC submitters rate it definitive or strong

How TCTN3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where TCTN3 sits. TCTN3 and 9 genes near it on chromosome 10, from 95,178,664 to 96,178,663.Chromosome 1010q24.1p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.395.2 Mb95.4 Mb95.6 Mb95.8 Mb96 MbACSM6: 95,194,200–95,228,929, forward strandACSM6PDLIM1: 95,237,569–95,291,126, reverse strandPDLIM1SORBS1: 95,311,390–95,561,469, reverse strandSORBS1ALDH18A1: 95,605,937–95,656,885, reverse strandALDH18A1TCTN3: 95,663,401–95,693,927, reverse strandTCTN3ENTPD1: 95,711,752–95,901,433, forward strandENTPD1: 95,860,548–95,924,844, forward strandCC2D2B: 95,907,603–96,033,745, forward strandCC2D2BCCNJ: 96,043,053–96,060,870, forward strandCCNJZNF518A: 96,129,695–96,205,288, forward strandZNF518ADiagram of TCTN3: 14 exons on the reverse strand of chromosome 10Exon 14: 1 known disease-causing siteExon 13: 3 known disease-causing sitesExon 12: 5 known disease-causing sitesExon 11: 2 known disease-causing sitesExon 10: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 8: 4 known disease-causing sitesExon 7: 1 known disease-causing siteExon 6: 5 known disease-causing sitesExon 5: 5 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 2: 3 known disease-causing sitesExon 1: 7 known disease-causing sitesExon 14: 95,663,401–95,664,300, 900 basesExon 13: 95,680,472–95,680,609, 138 basesExon 12: 95,682,651–95,682,804, 154 basesExon 11: 95,683,101–95,683,195, 95 basesExon 10: 95,683,522–95,683,629, 108 basesExon 9: 95,684,499–95,684,624, 126 basesExon 8: 95,685,556–95,685,636, 81 basesExon 7: 95,686,495–95,686,530, 36 basesExon 6: 95,687,044–95,687,159, 116 basesExon 5: 95,687,247–95,687,355, 109 basesExon 4: 95,687,592–95,687,719, 128 basesExon 3: 95,692,920–95,693,038, 119 basesExon 2: 95,693,353–95,693,476, 124 basesExon 1: 95,693,644–95,693,927, 284 bases1410515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 30.5 kb; 1,824 of those bases code for the protein.

How a genome test reads TCTN3

55

positions in TCTN3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 30.5 kb of TCTN3, introns included, not only the 2.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TCTN3 gene: tectonic family member 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/tctn3

Vancouver

Dante Labs. TCTN3 gene: tectonic family member 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tctn3

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