Trait

Webbed first and second toes

Clinical name: 1-2 toe syndactyly

Syndactyly with fusion of toes one and two.

HPO HP:0010711

Also called: Webbed 1st-2nd toes
Body system: Abnormality of limbs Abnormality of the musculoskeletal system

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4 genes linked to Webbed first and second toes

Changes in these genes cause rare conditions in which Webbed first and second toes is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
LEF1lymphoid enhancer binding factor 1	Always	In 1 condition
MAP3K20mitogen-activated protein kinase kinase kinase 20	Often (30–79%)	In 2 conditions
SALL1spalt like transcription factor 1	Sometimes (5–29%)	In 1 condition
SMC1Astructural maintenance of chromosomes 1A	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Fused toes

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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