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Trait

Webbed first through fourth toes

Clinical name: 1-4 toe syndactyly

Syndactyly with fusion of toes one to four.

HPO HP:0010712

Summary

Body system
Abnormality of limbsAbnormality of the musculoskeletal system

1 gene linked to Webbed first through fourth toes

Changes in these genes cause rare conditions in which Webbed first through fourth toes is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
NEDD4LNEDD4 like E3 ubiquitin protein ligaseSometimes (5–29%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Fused toes

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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