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Gene

DLL4

delta like canonical Notch ligand 4

Summary

Cytogenetic location
15q15.1
Coordinates
Chromosome 15: 40,929,340–40,939,073 (GRCh38)
Exons
11 exons across 9.7 kb
Protein
685 amino acids
MANE Select transcript
ENST00000249749.7NM_019074.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads DLL4 yet. The test sequences your whole genome, so your data includes it all the same.

How DLL4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 15, with a bracket where DLL4 sits. DLL4 and 25 genes near it on chromosome 15, from 40,434,207 to 41,434,206.Chromosome 1515q15.1p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.340.6 Mb40.8 Mb41 Mb41.2 Mb41.4 MbIVD: 40,405,485–40,435,956, forward strandIVDBAHD1: 40,436,611–40,468,242, forward strandBAHD1CHST14: 40,470,984–40,473,158, forward strandCHST14CCDC32: 40,519,519–40,565,054, reverse strandCCDC32RPUSD2: 40,569,289–40,575,171, forward strandRPUSD2KNL1: 40,594,002–40,664,342, forward strandKNL1RAD51: 40,694,774–40,732,344, forward strandRAD51RMDN3: 40,720,655–40,755,851, reverse strandRMDN3GCHFR: 40,764,043–40,767,872, forward strandDNAJC17: 40,765,161–40,807,498, reverse strandDNAJC17C15orf62: 40,769,980–40,772,449, forward strandC15orf62ZFYVE19: 40,807,086–40,815,084, forward strandZFYVE19PPP1R14D: 40,814,731–40,829,395, reverse strandPPP1R14DSPINT1: 40,843,513–40,860,274, forward strandSPINT1RHOV: 40,872,214–40,874,245, reverse strandRHOVVPS18: 40,894,412–40,903,975, forward strandVPS18DLL4: 40,929,340–40,939,073, forward strandDLL4CHAC1: 40,952,962–40,957,478, forward strandCHAC1INO80: 40,978,880–41,116,568, reverse strandINO80EXD1: 41,182,725–41,230,757, reverse strandEXD1CHP1: 41,230,824–41,281,888, forward strandCHP1: 41,284,007–41,380,996, forward strandOIP5: 41,306,412–41,332,680, reverse strandOIP5NUSAP1: 41,320,794–41,381,367, forward strandNUSAP1NDUFAF1: 41,387,218–41,409,403, reverse strandNDUFAF1RTF1: 41,408,408–41,483,563, forward strandRTF1Diagram of DLL4: 11 exons on the forward strand of chromosome 15Exon 2: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 8: 2 known disease-causing sitesExon 9: 11 known disease-causing sitesExon 1: 40,929,340–40,929,734, 395 basesExon 2: 40,929,847–40,930,116, 270 basesExon 3: 40,930,625–40,930,682, 58 basesExon 4: 40,931,503–40,931,766, 264 basesExon 5: 40,932,171–40,932,231, 61 basesExon 6: 40,932,317–40,932,447, 131 basesExon 7: 40,934,548–40,934,717, 170 basesExon 8: 40,934,898–40,935,117, 220 basesExon 9: 40,936,228–40,936,930, 703 basesExon 10: 40,937,418–40,937,526, 109 basesExon 11: 40,938,029–40,939,073, 1,045 bases12345678910115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.4 kb of the gene's 9.7 kb; 2,058 of those bases code for the protein.

How a genome test reads DLL4

21

positions in DLL4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 9.7 kb of DLL4, introns included, not only the 3.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DLL4 gene: delta like canonical Notch ligand 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/dll4

Vancouver

Dante Labs. DLL4 gene: delta like canonical Notch ligand 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dll4

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