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Trait

Webbed 3rd-4th toes

Clinical name: 3-4 toe syndactyly

Syndactyly with fusion of toes three and four.

HPO HP:0009779

Summary

Also called
syndactyly of 3rd - 4th toes
Body system
Abnormality of limbsAbnormality of the musculoskeletal system

7 genes linked to Webbed 3rd-4th toes

Changes in these genes cause rare conditions in which Webbed 3rd-4th toes is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
CCNQcyclin QAlwaysIn 1 condition
SMOsmoothened, frizzled class receptorOften (30–79%)In 1 condition
CDH3cadherin 3Sometimes (5–29%)In 1 condition
HOXD13homeobox D13Sometimes (5–29%)In 1 condition
RHOAras homolog family member ASometimes (5–29%)In 1 condition
GJA1gap junction protein alpha 1Not recordedIn 1 condition
SALL1spalt like transcription factor 1Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Fused toes

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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