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Gene

FANCF

FA complementation group F

Summary

Cytogenetic location
11p14.3
Coordinates
Chromosome 11: 22,622,533–22,625,823 (GRCh38)
Exons
1 exon across 3.3 kb
Protein
374 amino acids
Inheritance
Autosomal recessive
Also known as
FAF
MANE Select transcript
ENST00000327470.6NM_022725.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • DNA Repair Disease

    • Autosomal recessive

      A disease that has its basis in the disruption of DNA repair.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

  • Fanconi Anemia

    • Autosomal recessive

      Fanconi anemia (FA) is a hereditary DNA repair disorder characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Hematopoietic stem cell transplantation using FA-specific reduced-intensity conditioning; androgens (oxymetholone) as bridge therapy; cancer surveillance for head/neck and gynecological malignancies; gene therapy in clinical trials

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How FANCF is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 11, with a bracket where FANCF sits. FANCF and 5 genes near it on chromosome 11, from 22,124,178 to 23,124,177.Chromosome 1111p14.3p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2522.2 Mb22.4 Mb22.6 Mb22.8 Mb23 MbANO5: 21,782,659–22,283,567, forward strandANO5SLC17A6: 22,337,853–22,379,503, forward strandSLC17A6FANCF: 22,622,533–22,625,823, reverse strandFANCFGAS2: 22,625,509–22,813,803, forward strandGAS2SVIP: 22,812,155–22,830,299, reverse strandSVIPCCDC179: 22,846,922–22,860,476, reverse strandCCDC179Diagram of FANCF: one exon on the reverse strand of chromosome 11Exon 1: 53 known disease-causing sitesExon 1: 22,622,533–22,625,823, 3,291 bases15′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.3 kb of the gene's 3.3 kb; 1,125 of those bases code for the protein.

How a genome test reads FANCF

53

positions in FANCF where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3.3 kb of FANCF, introns included, not only the 3.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FANCF gene: FA complementation group F. Retrieved 17 October 2026, from https://dantelabs.com/genes/fancf

Vancouver

Dante Labs. FANCF gene: FA complementation group F [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fancf

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