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Gene

NR4A2

nuclear receptor subfamily 4 group A member 2

Summary

Cytogenetic location
2q24.1
Coordinates
Chromosome 2: 156,324,437–156,332,721 (GRCh38)
Exons
8 exons across 8.3 kb
Protein
598 amino acids
Also known as
TINUR, NOT, RNR1, HZF-3
Previous symbols
NURR1
MANE Select transcript
ENST00000339562.9NM_006186.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Dystonia, Myotonia, Paroxysmal Dyskinesia

    • Inherited Dystonia

      Umbrella term covering inherited dystonias, including DYT-TOR1A early-onset generalized dystonia, DYT-THAP1, myoclonus-dystonia (SGCE) and KMT2B-related dystonia.

      • 2 GenCC submitters rate it definitive or strong

How NR4A2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 2, with a bracket where NR4A2 sits. NR4A2 and 1 gene near it on chromosome 2, from 155,828,579 to 156,828,578.Chromosome 22q24.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3156 Mb156.2 Mb156.4 Mb156.6 Mb156.8 MbNR4A2: 156,324,437–156,332,721, reverse strandNR4A2GPD2: 156,435,290–156,614,702, forward strandGPD2Diagram of NR4A2: 8 exons on the reverse strand of chromosome 2Exon 7: 2 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 3: 18 known disease-causing sitesExon 8: 156,324,437–156,326,000, 1,564 basesExon 7: 156,326,150–156,326,328, 179 basesExon 6: 156,326,718–156,326,920, 203 basesExon 5: 156,327,851–156,328,014, 164 basesExon 4: 156,328,404–156,328,533, 130 basesExon 3: 156,329,323–156,330,188, 866 basesExon 2: 156,330,668–156,330,791, 124 basesExon 1: 156,332,480–156,332,721, 242 bases876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.5 kb of the gene's 8.3 kb; 1,797 of those bases code for the protein.

How a genome test reads NR4A2

28

positions in NR4A2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 8.3 kb of NR4A2, introns included, not only the 3.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NR4A2 gene: nuclear receptor subfamily 4 group A member 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/nr4a2

Vancouver

Dante Labs. NR4A2 gene: nuclear receptor subfamily 4 group A member 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nr4a2

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