Trait

Webbed 4th-5th toes

Clinical name: 4-5 toe syndactyly

Syndactyly with fusion of toes four and five.

HPO HP:0004692

Also called: Symmetric syndactyly, toes 4 and 5, Syndactyly of toes 4 and 5
Body system: Abnormality of limbs Abnormality of the musculoskeletal system

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12 condition reports read genes linked to this trait

Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.

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14 genes linked to Webbed 4th-5th toes

Changes in these genes cause rare conditions in which Webbed 4th-5th toes is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
CCNQcyclin Q	Always	In 1 condition
NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL	Always	In 1 condition
SF3B4splicing factor 3b subunit 4	Always	In 1 condition
HOXD13homeobox D13	Often (30–79%)	In 2 conditions
LRRC8Cleucine rich repeat containing 8 VRAC subunit C	Often (30–79%)	In 1 condition
MAP3K20mitogen-activated protein kinase kinase kinase 20	Often (30–79%)	In 2 conditions
MYCNMYCN proto-oncogene, bHLH transcription factor	Often (30–79%)	In 2 conditions
NECTIN4nectin cell adhesion molecule 4	Often (30–79%)	In 1 condition
NSUN2NOP2/Sun RNA methyltransferase 2	Often (30–79%)	In 1 condition
TELO2telomere maintenance 2	Often (30–79%)	In 1 condition
TMEM231transmembrane protein 231	Often (30–79%)	In 1 condition
SALL1spalt like transcription factor 1	Sometimes (5–29%)	In 1 condition
RBBP8RB binding protein 8, endonuclease	Not recorded	In 1 condition
TBX15T-box transcription factor 15	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

4-5 toe cutaneous syndactyly2 genes

Broader traits

Fused toes

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.19-9814e911.

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