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Gene

RFWD3

ring finger and WD repeat domain 3

Summary

Cytogenetic location
16q23.1
Coordinates
Chromosome 16: 74,621,399–74,666,877 (GRCh38)
Exons
13 exons across 45.5 kb
Protein
774 amino acids
Also known as
FLJ10520, RNF201, FANCW
MANE Select transcript
ENST00000361070.9NM_018124.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads RFWD3 yet. The test sequences your whole genome, so your data includes it all the same.

How RFWD3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 16, with a bracket where RFWD3 sits. RFWD3 and 9 genes near it on chromosome 16, from 74,144,138 to 75,144,137.Chromosome 1616q23.1p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.374.2 Mb74.4 Mb74.6 Mb74.8 Mb75 MbPSMD7: 74,296,781–74,306,290, forward strandPSMD7NPIPB15: 74,376,306–74,392,115, forward strandNPIPB15CLEC18B: 74,408,631–74,424,179, reverse strandCLEC18BGLG1: 74,447,427–74,607,144, reverse strandGLG1RFWD3: 74,621,399–74,666,877, reverse strandRFWD3MLKL: 74,671,855–74,701,170, reverse strandMLKLFA2H: 74,712,955–74,774,837, reverse strandFA2HWDR59: 74,862,165–75,000,173, reverse strandWDR59ZNRF1: 74,999,007–75,110,994, forward strandZNRF1LDHD: 75,111,855–75,116,799, reverse strandLDHDDiagram of RFWD3: 13 exons on the reverse strand of chromosome 16Exon 12: 1 known disease-causing siteExon 13: 74,621,399–74,624,071, 2,673 basesExon 12: 74,626,343–74,626,554, 212 basesExon 11: 74,628,452–74,628,666, 215 basesExon 10: 74,630,781–74,630,957, 177 basesExon 9: 74,632,523–74,632,673, 151 basesExon 8: 74,636,346–74,636,577, 232 basesExon 7: 74,637,856–74,637,970, 115 basesExon 6: 74,644,362–74,644,453, 92 basesExon 5: 74,644,541–74,644,735, 195 basesExon 4: 74,649,132–74,649,202, 71 basesExon 3: 74,651,920–74,652,122, 203 basesExon 2: 74,660,932–74,661,451, 520 basesExon 1: 74,666,786–74,666,877, 92 bases131210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.9 kb of the gene's 45.5 kb; 2,325 of those bases code for the protein.

How a genome test reads RFWD3

1

position in RFWD3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 45.5 kb of RFWD3, introns included, not only the 4.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RFWD3 gene: ring finger and WD repeat domain 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/rfwd3

Vancouver

Dante Labs. RFWD3 gene: ring finger and WD repeat domain 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rfwd3

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