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Gene

SPOP

speckle type BTB/POZ protein

Summary

Cytogenetic location
17q21.33
Coordinates
Chromosome 17: 49,598,884–49,678,097 (GRCh38)
Exons
10 exons across 79.2 kb
Protein
374 amino acids
Also known as
TEF2, BTBD32
MANE Select transcript
ENST00000504102.6NM_001007228.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SPOP yet. The test sequences your whole genome, so your data includes it all the same.

How SPOP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where SPOP sits. SPOP and 18 genes near it on chromosome 17, from 49,138,491 to 50,138,490.Chromosome 1717q21.33p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.349.2 Mb49.4 Mb49.6 Mb49.8 Mb50 MbB4GALNT2: 49,132,460–49,178,647, forward strandB4GALNT2GNGT2: 49,202,791–49,210,610, reverse strandGNGT2ABI3: 49,210,388–49,224,184, forward strandABI3PHOSPHO1: 49,223,346–49,230,831, reverse strandPHOSPHO1ZNF652: 49,289,206–49,362,473, reverse strandZNF652PHB1: 49,404,009–49,436,245, reverse strandPHB1NGFR: 49,495,286–49,515,020, forward strandNGFRNXPH3: 49,575,716–49,583,827, forward strandNXPH3SPOP: 49,598,884–49,678,097, reverse strandSPOPSLC35B1: 49,682,022–49,709,014, reverse strandSLC35B1FAM117A: 49,710,332–49,789,180, reverse strandFAM117AKAT7: 49,788,624–49,835,026, forward strandKAT7TAC4: 49,838,300–49,848,071, reverse strandTAC4DLX4: 49,968,588–49,974,959, forward strandDLX4DLX3: 49,990,005–49,995,224, reverse strandDLX3ITGA3: 50,055,968–50,090,933, forward strandITGA3PDK2: 50,094,737–50,120,276, forward strandPDK2SAMD14: 50,110,040–50,130,160, reverse strandSAMD14PPP1R9B: 50,133,732–50,151,020, reverse strandPPP1R9BDiagram of SPOP: 10 exons on the reverse strand of chromosome 17Exon 5: 5 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 2: 1 known disease-causing siteExon 10: 49,598,884–49,600,522, 1,639 basesExon 9: 49,601,865–49,602,007, 143 basesExon 8: 49,607,250–49,607,372, 123 basesExon 7: 49,607,874–49,607,929, 56 basesExon 6: 49,611,280–49,611,457, 178 basesExon 5: 49,618,981–49,619,108, 128 basesExon 4: 49,619,234–49,619,385, 152 basesExon 3: 49,621,946–49,622,067, 122 basesExon 2: 49,622,733–49,622,876, 144 basesExon 1: 49,677,933–49,678,097, 165 bases10864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.9 kb of the gene's 79.2 kb; 1,125 of those bases code for the protein.

How a genome test reads SPOP

10

positions in SPOP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 79.2 kb of SPOP, introns included, not only the 2.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SPOP gene: speckle type BTB/POZ protein. Retrieved 17 October 2026, from https://dantelabs.com/genes/spop

Vancouver

Dante Labs. SPOP gene: speckle type BTB/POZ protein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/spop

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