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Gene

LEMD3

LEM domain containing 3

Summary

Cytogenetic location
12q14.3
Coordinates
Chromosome 12: 65,169,583–65,248,355 (GRCh38)
Exons
13 exons across 78.8 kb
Protein
911 amino acids
Also known as
MAN1
MANE Select transcript
ENST00000308330.3NM_014319.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads LEMD3 yet. The test sequences your whole genome, so your data includes it all the same.

How LEMD3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where LEMD3 sits. LEMD3 and 5 genes near it on chromosome 12, from 64,708,969 to 65,708,968.Chromosome 1212q14.3p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3364.8 Mb65 Mb65.2 Mb65.4 Mb65.6 MbGNS: 64,713,442–64,759,449, reverse strandGNSTBC1D30: 64,759,484–64,881,033, forward strandTBC1D30: 64,759,496–64,977,509, forward strandWIF1: 65,050,565–65,121,582, reverse strandWIF1LEMD3: 65,169,583–65,248,355, forward strandLEMD3MSRB3: 65,278,542–65,505,156, forward strandMSRB3Diagram of LEMD3: 13 exons on the forward strand of chromosome 12Exon 1: 3 known disease-causing sitesExon 3: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 6: 3 known disease-causing sitesExon 7: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 10: 2 known disease-causing sitesExon 1: 65,169,583–65,171,118, 1,536 basesExon 2: 65,210,926–65,210,963, 38 basesExon 3: 65,215,977–65,216,043, 67 basesExon 4: 65,218,552–65,218,619, 68 basesExon 5: 65,238,502–65,238,581, 80 basesExon 6: 65,238,669–65,238,814, 146 basesExon 7: 65,239,929–65,240,030, 102 basesExon 8: 65,240,136–65,240,238, 103 basesExon 9: 65,240,909–65,241,087, 179 basesExon 10: 65,243,388–65,243,469, 82 basesExon 11: 65,245,669–65,245,774, 106 basesExon 12: 65,245,861–65,245,939, 79 basesExon 13: 65,246,162–65,248,355, 2,194 bases1510135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.8 kb of the gene's 78.8 kb; 2,736 of those bases code for the protein.

How a genome test reads LEMD3

16

positions in LEMD3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 78.8 kb of LEMD3, introns included, not only the 4.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LEMD3 gene: LEM domain containing 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/lemd3

Vancouver

Dante Labs. LEMD3 gene: LEM domain containing 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/lemd3

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