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Gene

NANS

N-acetylneuraminate synthase

Summary

Cytogenetic location
9q22.33
Coordinates
Chromosome 9: 98,056,732–98,083,077 (GRCh38)
Exons
6 exons across 26.3 kb
Protein
359 amino acids
Also known as
SAS
MANE Select transcript
ENST00000210444.6NM_018946.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads NANS yet. The test sequences your whole genome, so your data includes it all the same.

How NANS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 9, with a bracket where NANS sits. NANS and 12 genes near it on chromosome 9, from 97,569,905 to 98,569,904.Chromosome 99q22.33p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.397.6 Mb97.8 Mb98 Mb98.2 Mb98.4 MbTMOD1: 97,501,180–97,606,817, forward strandTMOD1TSTD2: 97,600,080–97,633,576, reverse strandTSTD2NCBP1: 97,633,402–97,676,992, forward strandNCBP1XPA: 97,653,139–97,697,408, reverse strandXPAFOXE1: 97,853,226–97,856,717, forward strandFOXE1TRMO: 97,894,512–97,922,570, reverse strandTRMOHEMGN: 97,926,791–97,944,856, reverse strandHEMGNANP32B: 97,983,126–98,017,079, forward strandANP32BTRIM14: 98,035,242–98,119,404, reverse strandTRIM14NANS: 98,056,732–98,083,077, forward strandNANSCORO2A: 98,120,975–98,193,206, reverse strandCORO2ATBC1D2: 98,198,999–98,256,427, reverse strandTBC1D2GABBR2: 98,288,087–98,709,739, reverse strandGABBR2Diagram of NANS: 6 exons on the forward strand of chromosome 9Exon 5: 2 known disease-causing sitesExon 1: 98,056,732–98,056,940, 209 basesExon 2: 98,060,782–98,060,997, 216 basesExon 3: 98,076,918–98,077,017, 100 basesExon 4: 98,078,193–98,078,347, 155 basesExon 5: 98,080,816–98,081,082, 267 basesExon 6: 98,082,846–98,083,077, 232 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.2 kb of the gene's 26.3 kb; 1,080 of those bases code for the protein.

How a genome test reads NANS

3

positions in NANS where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 26.3 kb of NANS, introns included, not only the 1.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NANS gene: N-acetylneuraminate synthase. Retrieved 17 October 2026, from https://dantelabs.com/genes/nans

Vancouver

Dante Labs. NANS gene: N-acetylneuraminate synthase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nans

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