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Gene

AFF4

ALF transcription elongation factor 4

Summary

Cytogenetic location
5q31.1
Coordinates
Chromosome 5: 132,875,395–132,963,634 (GRCh38)
Exons
21 exons across 88.2 kb
Protein
1,163 amino acids
Also known as
AF5Q31, MCEF
MANE Select transcript
ENST00000265343.10NM_014423.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads AFF4 yet. The test sequences your whole genome, so your data includes it all the same.

How AFF4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where AFF4 sits. AFF4 and 17 genes near it on chromosome 5, from 132,419,515 to 133,419,514.Chromosome 55q31.1p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3132.6 Mb132.8 Mb133 Mb133.2 Mb133.4 Mb: 132,410,832–132,646,079, forward strandIRF1: 132,440,440–132,508,719, reverse strandIRF1IL5: 132,541,444–132,556,838, reverse strandIL5RAD50: 132,556,019–132,646,349, forward strandRAD50IL13: 132,656,263–132,661,110, forward strandIL13IL4: 132,673,986–132,682,678, forward strandIL4KIF3A: 132,688,806–132,737,638, reverse strandKIF3ACCNI2: 132,747,319–132,765,178, forward strandCCNI2SEPTIN8: 132,750,138–132,807,241, reverse strandSEPTIN8SOWAHA: 132,813,302–132,816,786, forward strandSOWAHASHROOM1: 132,821,271–132,830,924, reverse strandSHROOM1GDF9: 132,861,181–132,866,884, reverse strandGDF9UQCRQ: 132,866,623–132,868,847, forward strandUQCRQLEAP2: 132,873,444–132,899,343, forward strandLEAP2AFF4: 132,875,395–132,963,634, reverse strandAFF4ZCCHC10: 132,996,985–133,026,604, reverse strandZCCHC10HSPA4: 133,051,942–133,106,449, forward strandHSPA4FSTL4: 133,193,430–133,612,688, reverse strandFSTL4Diagram of AFF4: 21 exons on the reverse strand of chromosome 5Exon 3: 5 known disease-causing sitesExon 2: 1 known disease-causing siteExon 21: 132,875,395–132,881,186, 5,792 basesExon 20: 132,883,340–132,883,560, 221 basesExon 19: 132,885,076–132,885,119, 44 basesExon 18: 132,886,310–132,886,403, 94 basesExon 17: 132,887,521–132,887,592, 72 basesExon 16: 132,887,846–132,887,982, 137 basesExon 15: 132,888,097–132,888,160, 64 basesExon 14: 132,889,079–132,889,173, 95 basesExon 13: 132,892,164–132,892,404, 241 basesExon 12: 132,893,030–132,893,118, 89 basesExon 11: 132,896,323–132,897,240, 918 basesExon 10: 132,898,230–132,898,392, 163 basesExon 9: 132,899,104–132,899,141, 38 basesExon 8: 132,899,587–132,899,641, 55 basesExon 7: 132,902,442–132,902,487, 46 basesExon 6: 132,904,368–132,904,404, 37 basesExon 5: 132,927,121–132,927,207, 87 basesExon 4: 132,932,178–132,932,222, 45 basesExon 3: 132,934,147–132,934,941, 795 basesExon 2: 132,937,067–132,937,193, 127 basesExon 1: 132,963,259–132,963,634, 376 bases21201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9.5 kb of the gene's 88.2 kb; 3,492 of those bases code for the protein.

How a genome test reads AFF4

6

positions in AFF4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 88.2 kb of AFF4, introns included, not only the 9.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). AFF4 gene: ALF transcription elongation factor 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/aff4

Vancouver

Dante Labs. AFF4 gene: ALF transcription elongation factor 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/aff4

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