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Gene

FBXO28

F-box protein 28

Summary

Cytogenetic location
1q42.11
Coordinates
Chromosome 1: 224,114,111–224,162,047 (GRCh38)
Exons
5 exons across 47.9 kb
Protein
368 amino acids
Also known as
FLJ10766, KIAA0483, Fbx28, CENP-30
MANE Select transcript
ENST00000366862.10NM_015176.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • 4 GenCC submitters rate it definitive or strong

    How FBXO28 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 1, with a bracket where FBXO28 sits. FBXO28 and 8 genes near it on chromosome 1, from 223,638,079 to 224,638,078.Chromosome 11q42.11p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44223.8 Mb224 Mb224.2 Mb224.4 Mb224.6 MbCAPN8: 223,538,007–223,665,737, reverse strandCAPN8CAPN2: 223,701,561–223,776,018, forward strandCAPN2TP53BP2: 223,779,893–223,846,012, reverse strandTP53BP2FBXO28: 224,114,111–224,162,047, forward strandFBXO28DEGS1: 224,175,756–224,202,394, forward strandDEGS1NVL: 224,227,334–224,330,287, reverse strandNVLCNIH4: 224,356,810–224,381,575, forward strandCNIH4WDR26: 224,385,146–224,437,033, reverse strandWDR26CNIH3: 224,434,660–224,740,565, forward strandCNIH3Diagram of FBXO28: 5 exons on the forward strand of chromosome 1Exon 5: 2 known disease-causing sitesExon 1: 224,114,111–224,114,396, 286 basesExon 2: 224,130,472–224,130,581, 110 basesExon 3: 224,134,074–224,134,212, 139 basesExon 4: 224,153,142–224,153,337, 196 basesExon 5: 224,157,352–224,162,047, 4,696 bases123455′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 5.4 kb of the gene's 47.9 kb; 1,107 of those bases code for the protein.

    How a genome test reads FBXO28

    2

    positions in FBXO28 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 47.9 kb of FBXO28, introns included, not only the 5.4 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). FBXO28 gene: F-box protein 28. Retrieved 16 October 2026, from https://dantelabs.com/genes/fbxo28

    Vancouver

    Dante Labs. FBXO28 gene: F-box protein 28 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/fbxo28

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