Skip to content
Use your HSA or FSA funds

Gene

ANKRD11

ankyrin repeat domain 11

Summary

Cytogenetic location
16q24.3
Coordinates
Chromosome 16: 89,267,630–89,490,561 (GRCh38)
Exons
13 exons across 222.9 kb
Protein
2,663 amino acids
Also known as
LZ16, T13, ANCO1, ANCO-1
MANE Select transcript
ENST00000301030.10NM_013275.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Intellectual Disability

      • One of 233 genes linked to it

        • ClinGen rates the link definitive
        • 6 GenCC submitters rate it definitive or strong

    How ANKRD11 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 16, with a bracket where ANKRD11 sits. ANKRD11 and 19 genes near it on chromosome 16, from 88,879,096 to 89,879,095.Chromosome 1616q24.3p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.389 Mb89.2 Mb89.4 Mb89.6 Mb89.8 MbCBFA2T3: 88,874,858–88,977,207, reverse strandCBFA2T3ACSF3: 89,088,375–89,164,121, forward strandACSF3CDH15: 89,171,742–89,195,492, forward strandCDH15SLC22A31: 89,195,458–89,201,692, reverse strandSLC22A31ZNF778: 89,217,683–89,237,141, forward strandZNF778ANKRD11: 89,267,630–89,490,561, reverse strandANKRD11: 89,317,046–89,418,292, reverse strandSPG7: 89,490,719–89,557,768, forward strandSPG7RPL13: 89,560,637–89,567,834, forward strandRPL13CPNE7: 89,575,730–89,597,247, forward strandCPNE7DPEP1: 89,613,308–89,638,456, forward strandDPEP1CHMP1A: 89,640,816–89,657,738, reverse strandCHMP1ASPATA33: 89,657,740–89,671,287, forward strandSPATA33CDK10: 89,680,737–89,696,372, forward strandCDK10SPATA2L: 89,696,357–89,701,733, reverse strandSPATA2LVPS9D1: 89,707,128–89,721,879, reverse strandVPS9D1ZNF276: 89,720,400–89,740,925, forward strandZNF276FANCA: 89,726,683–89,816,977, reverse strandFANCASPIRE2: 89,818,179–89,871,320, forward strandSPIRE2TCF25: 89,873,214–89,913,627, forward strandTCF25Diagram of ANKRD11: 13 exons on the reverse strand of chromosome 16Exon 13: 2 known disease-causing sitesExon 12: 7 known disease-causing sitesExon 11: 10 known disease-causing sitesExon 10: 8 known disease-causing sitesExon 9: 344 known disease-causing sitesExon 8: 4 known disease-causing sitesExon 7: 6 known disease-causing sitesExon 6: 9 known disease-causing sitesExon 5: 7 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 13: 89,267,630–89,268,663, 1,034 basesExon 12: 89,270,817–89,270,909, 93 basesExon 11: 89,274,814–89,274,957, 144 basesExon 10: 89,275,093–89,275,191, 99 basesExon 9: 89,279,072–89,285,649, 6,578 basesExon 8: 89,286,039–89,286,186, 148 basesExon 7: 89,288,528–89,288,670, 143 basesExon 6: 89,290,625–89,290,828, 204 basesExon 5: 89,291,013–89,291,183, 171 basesExon 4: 89,305,206–89,305,344, 139 basesExon 3: 89,316,933–89,317,078, 146 basesExon 2: 89,418,284–89,418,368, 85 basesExon 1: 89,490,245–89,490,561, 317 bases1310515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 9.3 kb of the gene's 222.9 kb; 7,992 of those bases code for the protein.

    How a genome test reads ANKRD11

    421

    positions in ANKRD11 where ClinVar classes a change as pathogenic or likely pathogenic

    101 of them (24%) fall in regions short reads find hard.

    • Low mappability (35 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
    • Segmental duplications (66 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

    A whole genome covers all 222.9 kb of ANKRD11, introns included, not only the 9.3 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). ANKRD11 gene: ankyrin repeat domain 11. Retrieved 17 October 2026, from https://dantelabs.com/genes/ankrd11

    Vancouver

    Dante Labs. ANKRD11 gene: ankyrin repeat domain 11 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ankrd11

    One test. A lifetime of answers.

    From $449Free shipping · Results in 6–8 weeks

    Get my Genome Test