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Gene

TRIM8

tripartite motif containing 8

Summary

Cytogenetic location
10q24.32
Coordinates
Chromosome 10: 102,644,479–102,658,318 (GRCh38)
Exons
6 exons across 13.8 kb
Protein
551 amino acids
Also known as
GERP
Previous symbols
RNF27
MANE Select transcript
ENST00000643721.2NM_030912.3
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads TRIM8 yet. The test sequences your whole genome, so your data includes it all the same.

How TRIM8 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 10, with a bracket where TRIM8 sits. TRIM8 and 21 genes near it on chromosome 10, from 102,151,399 to 103,151,398.Chromosome 1010q24.32p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.3102.2 Mb102.4 Mb102.6 Mb102.8 Mb103 MbNOLC1: 102,152,170–102,163,875, forward strandNOLC1ELOVL3: 102,226,294–102,229,589, forward strandELOVL3PITX3: 102,229,754–102,241,512, reverse strandPITX3GBF1: 102,245,371–102,382,899, forward strandGBF1NFKB2: 102,394,110–102,402,529, forward strandPSD: 102,402,614–102,421,539, reverse strandPSDFBXL15: 102,408,835–102,423,142, forward strandFBXL15CUEDC2: 102,423,239–102,432,718, reverse strandCUEDC2C10orf95: 102,449,619–102,451,548, reverse strandC10orf95SLC68A1: 102,461,363–102,477,046, forward strandSLC68A1ACTR1A: 102,461,881–102,502,744, reverse strandACTR1ASUFU: 102,503,952–102,633,535, forward strandSUFUTRIM8: 102,644,479–102,658,318, forward strandTRIM8ARL3: 102,673,731–102,714,527, reverse strandARL3SFXN2: 102,714,476–102,743,492, forward strandSFXN2WBP1L: 102,743,923–102,834,613, forward strandWBP1LCYP17A1: 102,830,460–102,837,506, reverse strandCYP17A1BORCS7: 102,854,224–102,864,979, forward strandBORCS7BORCS7-ASMT: 102,854,272–102,901,899, forward strandBORCS7-ASMTAS3MT: 102,869,296–102,901,911, forward strandAS3MTCNNM2: 102,918,123–103,090,222, forward strandCNNM2NT5C2: 103,086,478–103,277,622, reverse strandNT5C2Diagram of TRIM8: 6 exons on the forward strand of chromosome 10Exon 6: 14 known disease-causing sitesExon 1: 102,644,479–102,645,187, 709 basesExon 2: 102,654,653–102,654,748, 96 basesExon 3: 102,655,080–102,655,313, 234 basesExon 4: 102,656,106–102,656,137, 32 basesExon 5: 102,656,270–102,656,385, 116 basesExon 6: 102,656,747–102,658,318, 1,572 bases12465′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.8 kb of the gene's 13.8 kb; 1,656 of those bases code for the protein.

Sequencing TRIM8

14

positions in TRIM8 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 13.8 kb of TRIM8, introns included, not only the 2.8 kb of exons.

Traits linked to TRIM8

The Human Phenotype Ontology lists these as features of the rare conditions TRIM8 can cause. Each trait's page lists the other genes linked to it.

Abnormality of the nervous system

Show 51 more traits

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TRIM8 gene: tripartite motif containing 8. Retrieved 17 October 2026, from https://dantelabs.com/genes/trim8

Vancouver

Dante Labs. TRIM8 gene: tripartite motif containing 8 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/trim8

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