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Gene

WARS1

tryptophanyl-tRNA synthetase 1

Summary

Cytogenetic location
14q32.2
Coordinates
Chromosome 14: 100,333,790–100,375,347 (GRCh38)
Exons
11 exons across 41.6 kb
Protein
471 amino acids
Also known as
IFP53
Previous symbols
IFI53, WARS
MANE Select transcript
ENST00000392882.7NM_004184.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Charcot-Marie-Tooth Disease

    • Distal Hereditary Motor Neuropathy

      Inherited neuropathies that mainly affect motor nerves, causing weakness and wasting of the hands and feet, including SORD-related neuropathy.

      • 2 GenCC submitters rate it definitive or strong

  • Spinal Muscular Atrophy

    • A group of disorders characterised by degeneration of spinal cord anterior horn cells, leading to progressive muscle weakness and atrophy.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Gene therapy (onasemnogene abeparvovec), antisense oligonucleotide therapy (nusinersen), oral splicing modifier (risdiplam), supportive care

How WARS1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where WARS1 sits. WARS1 and 9 genes near it on chromosome 14, from 99,854,569 to 100,854,568.Chromosome 1414q32.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.33100 Mb100.2 Mb100.4 Mb100.6 Mb100.8 MbEML1: 99,737,693–99,942,060, forward strandEML1EVL: 99,971,444–100,144,236, forward strandEVLDEGS2: 100,143,957–100,159,688, reverse strandDEGS2YY1: 100,238,298–100,282,788, forward strandYY1SLC25A29: 100,291,116–100,306,547, reverse strandSLC25A29SLC25A47: 100,323,156–100,330,421, forward strandSLC25A47WARS1: 100,333,790–100,375,347, reverse strandWARS1WDR25: 100,376,418–100,530,306, forward strandWDR25BEGAIN: 100,537,147–100,587,430, reverse strandBEGAINDLK1: 100,725,705–100,738,224, forward strandDLK1Diagram of WARS1: 11 exons on the reverse strand of chromosome 14Exon 11: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 11: 100,333,790–100,335,036, 1,247 basesExon 10: 100,337,062–100,337,202, 141 basesExon 9: 100,342,398–100,342,571, 174 basesExon 8: 100,343,275–100,343,387, 113 basesExon 7: 100,346,746–100,346,846, 101 basesExon 6: 100,353,687–100,353,869, 183 basesExon 5: 100,354,447–100,354,566, 120 basesExon 4: 100,360,554–100,360,662, 109 basesExon 3: 100,361,708–100,361,921, 214 basesExon 2: 100,369,087–100,369,258, 172 basesExon 1: 100,375,283–100,375,347, 65 bases11109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.6 kb of the gene's 41.6 kb; 1,416 of those bases code for the protein.

How a genome test reads WARS1

6

positions in WARS1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 41.6 kb of WARS1, introns included, not only the 2.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). WARS1 gene: tryptophanyl-tRNA synthetase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/wars1

Vancouver

Dante Labs. WARS1 gene: tryptophanyl-tRNA synthetase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/wars1

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