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Gene

PHIP

PHIP subunit of CUL4-Ring ligase complex

Summary

Cytogenetic location
6q14.1
Coordinates
Chromosome 6: 78,934,419–79,078,254 (GRCh38)
Exons
40 exons across 143.8 kb
Protein
1,821 amino acids
Also known as
ndrp, BRWD2, RepID, DCAF14, FLJ20705
Previous symbols
WDR11
MANE Select transcript
ENST00000275034.5NM_017934.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PHIP yet. The test sequences your whole genome, so your data includes it all the same.

How PHIP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where PHIP sits. PHIP and 3 genes near it on chromosome 6, from 78,506,337 to 79,506,336.Chromosome 66q14.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2778.6 Mb78.8 Mb79 Mb79.2 Mb79.4 MbIRAK1BP1: 78,867,482–78,995,327, forward strandIRAK1BP1PHIP: 78,934,419–79,078,254, reverse strandPHIPHMGN3: 79,199,425–79,234,862, reverse strandHMGN3LCA5: 79,484,991–79,545,138, reverse strandLCA5Diagram of PHIP: 40 exons on the reverse strand of chromosome 6Exon 40: 1 known disease-causing siteExon 39: 1 known disease-causing siteExon 38: 5 known disease-causing sitesExon 36: 1 known disease-causing siteExon 35: 3 known disease-causing sitesExon 34: 2 known disease-causing sitesExon 33: 1 known disease-causing siteExon 32: 2 known disease-causing sitesExon 31: 2 known disease-causing sitesExon 30: 3 known disease-causing sitesExon 28: 4 known disease-causing sitesExon 27: 2 known disease-causing sitesExon 26: 2 known disease-causing sitesExon 25: 2 known disease-causing sitesExon 24: 1 known disease-causing siteExon 23: 4 known disease-causing sitesExon 21: 1 known disease-causing siteExon 20: 3 known disease-causing sitesExon 19: 4 known disease-causing sitesExon 16: 4 known disease-causing sitesExon 15: 7 known disease-causing sitesExon 14: 3 known disease-causing sitesExon 13: 2 known disease-causing sitesExon 9: 3 known disease-causing sitesExon 8: 8 known disease-causing sitesExon 7: 5 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 2: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 40: 78,934,419–78,941,330, 6,912 basesExon 39: 78,945,300–78,945,497, 198 basesExon 38: 78,946,001–78,946,260, 260 basesExon 37: 78,946,711–78,946,874, 164 basesExon 36: 78,947,623–78,947,775, 153 basesExon 35: 78,954,814–78,954,963, 150 basesExon 34: 78,955,232–78,955,282, 51 basesExon 33: 78,955,613–78,955,682, 70 basesExon 32: 78,958,475–78,958,600, 126 basesExon 31: 78,961,690–78,961,810, 121 basesExon 30: 78,963,097–78,963,252, 156 basesExon 29: 78,965,703–78,965,764, 62 basesExon 28: 78,965,945–78,966,056, 112 basesExon 27: 78,969,835–78,969,917, 83 basesExon 26: 78,970,049–78,970,173, 125 basesExon 25: 78,970,781–78,970,888, 108 basesExon 24: 78,978,592–78,978,711, 120 basesExon 23: 78,982,886–78,983,117, 232 basesExon 22: 78,985,352–78,985,428, 77 basesExon 21: 78,988,209–78,988,349, 141 basesExon 20: 78,990,868–78,990,985, 118 basesExon 19: 78,997,414–78,997,597, 184 basesExon 18: 78,998,254–78,998,391, 138 basesExon 17: 79,001,899–79,002,124, 226 basesExon 16: 79,003,730–79,003,858, 129 basesExon 15: 79,015,082–79,015,216, 135 basesExon 14: 79,015,630–79,015,783, 154 basesExon 13: 79,016,544–79,016,642, 99 basesExon 12: 79,017,346–79,017,386, 41 basesExon 11: 79,017,483–79,017,583, 101 basesExon 10: 79,019,089–79,019,159, 71 basesExon 9: 79,025,519–79,025,619, 101 basesExon 8: 79,025,943–79,026,164, 222 basesExon 7: 79,042,843–79,043,003, 161 basesExon 6: 79,060,478–79,060,576, 99 basesExon 5: 79,060,668–79,060,818, 151 basesExon 4: 79,077,448–79,077,507, 60 basesExon 3: 79,077,700–79,077,729, 30 basesExon 2: 79,077,855–79,077,913, 59 basesExon 1: 79,078,029–79,078,254, 226 bases40353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 11.9 kb of the gene's 143.8 kb; 5,466 of those bases code for the protein.

How a genome test reads PHIP

101

positions in PHIP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 143.8 kb of PHIP, introns included, not only the 11.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PHIP gene: PHIP subunit of CUL4-Ring ligase complex. Retrieved 16 October 2026, from https://dantelabs.com/genes/phip

Vancouver

Dante Labs. PHIP gene: PHIP subunit of CUL4-Ring ligase complex [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/phip

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