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Gene

KNL1

kinetochore scaffold 1

Summary

Cytogenetic location
15q15.1
Coordinates
Chromosome 15: 40,594,249–40,664,342 (GRCh38)
Exons
26 exons across 70.1 kb
Protein
2,316 amino acids
Also known as
D40, AF15Q14, CT29, KIAA1570, hKNL-1, hSpc105, PPP1R55, Spc7
Previous symbols
MCPH4, CASC5
MANE Select transcript
ENST00000399668.7NM_144508.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads KNL1 yet. The test sequences your whole genome, so your data includes it all the same.

How KNL1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where KNL1 sits. KNL1 and 28 genes near it on chromosome 15, from 40,129,296 to 41,129,295.Chromosome 1515q15.1p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.340.2 Mb40.4 Mb40.6 Mb40.8 Mb41 MbBUB1B: 40,160,984–40,221,137, forward strandBUB1BPAK6: 40,217,428–40,277,489, forward strandPAK6BUB1B-PAK6: 40,218,500–40,264,890, forward strandBUB1B-PAK6PLCB2: 40,278,176–40,307,965, reverse strandPLCB2ANKRD63: 40,278,372–40,283,064, reverse strandANKRD63INAFM2: 40,323,692–40,326,715, forward strandINAFM2CCDC9B: 40,331,452–40,340,954, reverse strandCCDC9BPHGR1: 40,351,025–40,357,622, forward strandPHGR1DISP2: 40,358,219–40,378,621, forward strandDISP2KNSTRN: 40,382,721–40,395,659, forward strandKNSTRNIVD: 40,405,485–40,435,956, forward strandIVDBAHD1: 40,436,611–40,468,242, forward strandBAHD1CHST14: 40,470,984–40,473,158, forward strandCHST14CCDC32: 40,519,519–40,565,054, reverse strandCCDC32RPUSD2: 40,569,289–40,575,171, forward strandRPUSD2KNL1: 40,594,249–40,664,342, forward strandKNL1RAD51: 40,694,774–40,732,344, forward strandRAD51RMDN3: 40,720,655–40,755,851, reverse strandRMDN3GCHFR: 40,764,043–40,767,872, forward strandGCHFRDNAJC17: 40,765,161–40,807,498, reverse strandDNAJC17C15orf62: 40,769,980–40,772,449, forward strandC15orf62ZFYVE19: 40,807,086–40,815,084, forward strandZFYVE19PPP1R14D: 40,814,731–40,829,395, reverse strandSPINT1: 40,843,513–40,860,274, forward strandSPINT1RHOV: 40,872,214–40,874,245, reverse strandRHOVVPS18: 40,894,412–40,903,975, forward strandVPS18DLL4: 40,929,333–40,939,081, forward strandDLL4CHAC1: 40,952,962–40,957,478, forward strandCHAC1INO80: 40,978,880–41,116,568, reverse strandINO80Diagram of KNL1: 26 exons on the forward strand of chromosome 15Exon 5: 1 known disease-causing siteExon 10: 7 known disease-causing sitesExon 17: 1 known disease-causing siteExon 21: 1 known disease-causing siteExon 24: 1 known disease-causing siteExon 1: 40,594,249–40,594,392, 144 basesExon 2: 40,602,915–40,602,966, 52 basesExon 3: 40,605,110–40,605,149, 40 basesExon 4: 40,606,393–40,606,452, 60 basesExon 5: 40,608,847–40,608,908, 62 basesExon 6: 40,610,245–40,610,297, 53 basesExon 7: 40,611,478–40,611,511, 34 basesExon 8: 40,615,341–40,615,378, 38 basesExon 9: 40,618,959–40,619,011, 53 basesExon 10: 40,620,640–40,625,640, 5,001 basesExon 11: 40,628,070–40,628,208, 139 basesExon 12: 40,628,611–40,628,678, 68 basesExon 13: 40,629,273–40,629,371, 99 basesExon 14: 40,640,912–40,641,027, 116 basesExon 15: 40,644,997–40,645,087, 91 basesExon 16: 40,645,656–40,645,772, 117 basesExon 17: 40,646,987–40,647,074, 88 basesExon 18: 40,650,301–40,650,378, 78 basesExon 19: 40,650,544–40,650,583, 40 basesExon 20: 40,651,471–40,651,572, 102 basesExon 21: 40,652,005–40,652,105, 101 basesExon 22: 40,654,909–40,654,977, 69 basesExon 23: 40,657,042–40,657,151, 110 basesExon 24: 40,657,355–40,657,473, 119 basesExon 25: 40,659,339–40,659,461, 123 basesExon 26: 40,662,074–40,664,342, 2,269 bases1510152025265′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9.3 kb of the gene's 70.1 kb; 6,951 of those bases code for the protein.

How a genome test reads KNL1

11

positions in KNL1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 70.1 kb of KNL1, introns included, not only the 9.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KNL1 gene: kinetochore scaffold 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/knl1

Vancouver

Dante Labs. KNL1 gene: kinetochore scaffold 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/knl1

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