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Gene

UBR5

ubiquitin protein ligase E3 component n-recognin 5

Summary

Cytogenetic location
8q22.3
Coordinates
Chromosome 8: 102,252,273–102,412,700 (GRCh38)
Exons
59 exons across 160.4 kb
Protein
2,799 amino acids
Also known as
DD5, HYD, EDD, KIAA0896
Previous symbols
EDD1
MANE Select transcript
ENST00000520539.6NM_015902.6
Locus type
gene with protein product

Curated reports relevant to this gene

No Genome Test report reads UBR5 yet. The test sequences your whole genome, so your data includes it all the same.

How UBR5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 8, with a bracket where UBR5 sits. UBR5 and 5 genes near it on chromosome 8, from 101,832,487 to 102,832,486.Chromosome 88q22.3p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.3102 Mb102.2 Mb102.4 Mb102.6 Mb102.8 MbNCALD: 101,686,542–102,124,907, reverse strandNCALDRRM2B: 102,204,502–102,239,382, reverse strandRRM2BUBR5: 102,252,273–102,412,700, reverse strandUBR5ODF1: 102,551,589–102,561,018, forward strandODF1KLF10: 102,648,781–102,655,729, reverse strandKLF10AZIN1: 102,823,965–102,893,864, reverse strandAZIN1Diagram of UBR5: 59 exons on the reverse strand of chromosome 8Exon 12: 1 known disease-causing siteExon 59: 102,252,273–102,254,514, 2,242 basesExon 58: 102,257,632–102,257,717, 86 basesExon 57: 102,258,985–102,259,129, 145 basesExon 56: 102,261,146–102,261,259, 114 basesExon 55: 102,261,915–102,262,070, 156 basesExon 54: 102,264,474–102,264,558, 85 basesExon 53: 102,265,100–102,265,278, 179 basesExon 52: 102,266,947–102,267,007, 61 basesExon 51: 102,268,978–102,269,108, 131 basesExon 50: 102,270,039–102,270,183, 145 basesExon 49: 102,271,134–102,271,245, 112 basesExon 48: 102,272,529–102,272,772, 244 basesExon 47: 102,275,521–102,275,619, 99 basesExon 46: 102,275,708–102,275,828, 121 basesExon 45: 102,276,972–102,277,192, 221 basesExon 44: 102,278,826–102,278,939, 114 basesExon 43: 102,279,036–102,279,208, 173 basesExon 42: 102,280,394–102,280,467, 74 basesExon 41: 102,281,289–102,281,519, 231 basesExon 40: 102,285,127–102,285,338, 212 basesExon 39: 102,285,513–102,285,781, 269 basesExon 38: 102,286,360–102,286,617, 258 basesExon 37: 102,287,433–102,287,564, 132 basesExon 36: 102,288,155–102,288,266, 112 basesExon 35: 102,289,453–102,289,576, 124 basesExon 34: 102,293,605–102,293,844, 240 basesExon 33: 102,293,955–102,294,115, 161 basesExon 32: 102,294,982–102,295,111, 130 basesExon 31: 102,295,204–102,295,330, 127 basesExon 30: 102,295,414–102,295,532, 119 basesExon 29: 102,295,636–102,295,782, 147 basesExon 28: 102,296,893–102,296,984, 92 basesExon 27: 102,297,458–102,297,606, 149 basesExon 26: 102,298,392–102,298,489, 98 basesExon 25: 102,298,848–102,298,971, 124 basesExon 24: 102,299,452–102,299,547, 96 basesExon 23: 102,300,000–102,300,151, 152 basesExon 22: 102,304,043–102,304,169, 127 basesExon 21: 102,305,085–102,305,295, 211 basesExon 20: 102,311,299–102,311,496, 198 basesExon 19: 102,311,735–102,311,889, 155 basesExon 18: 102,312,134–102,312,245, 112 basesExon 17: 102,312,342–102,312,485, 144 basesExon 16: 102,313,804–102,313,916, 113 basesExon 15: 102,314,744–102,314,853, 110 basesExon 14: 102,323,311–102,323,495, 185 basesExon 13: 102,326,546–102,326,663, 118 basesExon 12: 102,327,742–102,327,896, 155 basesExon 11: 102,329,090–102,329,200, 111 basesExon 10: 102,329,283–102,329,399, 117 basesExon 9: 102,342,473–102,342,684, 212 basesExon 8: 102,345,396–102,345,545, 150 basesExon 7: 102,346,236–102,346,395, 160 basesExon 6: 102,346,903–102,347,092, 190 basesExon 5: 102,360,071–102,360,190, 120 basesExon 4: 102,360,589–102,360,665, 77 basesExon 3: 102,361,125–102,361,206, 82 basesExon 2: 102,361,582–102,361,626, 45 basesExon 1: 102,412,173–102,412,700, 528 bases59504030201015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10.9 kb of the gene's 160.4 kb; 8,400 of those bases code for the protein.

How a genome test reads UBR5

2

positions in UBR5 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 160.4 kb of UBR5, introns included, not only the 10.9 kb of exons.

Traits linked to UBR5

The Human Phenotype Ontology lists these as features of the rare conditions UBR5 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). UBR5 gene: ubiquitin protein ligase E3 component n-recognin 5. Retrieved 17 October 2026, from https://dantelabs.com/genes/ubr5

Vancouver

Dante Labs. UBR5 gene: ubiquitin protein ligase E3 component n-recognin 5 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ubr5

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