Trait
IQ between 34 and 49
Clinical name: Moderate intellectual disability
Moderate intellectual disability (ID) is defined as a type of ID characterized by moderately sub-average adaptive functioning and intellectual functioning, with an intelligence quotient (IQ) the range of 35-49.
Summary
- Also called
- Intellectual disability, moderate, Moderate mental deficiency
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to IQ between 34 and 49, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test213 genes linked to IQ between 34 and 49
Changes in these genes cause rare conditions in which IQ between 34 and 49 is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AGO1argonaute RISC component 1 | Always | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Always | In 1 condition |
| ANK3ankyrin 3 | Always | In 2 conditions |
| ATP6V0CATPase H+ transporting V0 subunit c | Always | In 1 condition |
| ATXN7L3ataxin 7 like 3 | Always | In 1 condition |
| CACNG2calcium voltage-gated channel auxiliary subunit gamma 2 | Always | In 1 condition |
| CDK5RAP2CDK5 regulatory subunit associated protein 2 | Always | In 1 condition |
| CNKSR2connector enhancer of kinase suppressor of Ras 2 | Always | In 1 condition |
| COG1component of oligomeric golgi complex 1 | Always | In 2 conditions |
| COQ4coenzyme Q4 | Always | In 1 condition |
| CPAPcentrosome assembly and centriole elongation protein | Always | In 1 condition |
| DARS2aspartyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| DMXL2Dmx like 2 | Always | In 2 conditions |
| EEFSECeukaryotic elongation factor, selenocysteine-tRNA specific | Always | In 1 condition |
| EGFepidermal growth factor | Always | In 1 condition |
| EXT2exostosin glycosyltransferase 2 | Always | In 2 conditions |
| FEM1Bfem-1 homolog B | Always | In 1 condition |
| FLVCR1FLVCR choline and heme transporter 1 | Always | In 1 condition |
| FMR1fragile X messenger ribonucleoprotein 1 | Always | In 2 conditions |
| FTSJ1FtsJ RNA 2'-O-methyltransferase 1 | Always | In 1 condition |
| GABRA1gamma-aminobutyric acid type A receptor subunit alpha1 | Always | In 1 condition |
| GTPBP2GTP binding protein 2 | Always | In 1 condition |
| HNRNPCheterogeneous nuclear ribonucleoprotein C | Always | In 1 condition |
| IL1RAPL1interleukin 1 receptor accessory protein like 1 | Always | In 1 condition |
| INPP4Ainositol polyphosphate-4-phosphatase type I A | Always | In 1 condition |
| INPP5Einositol polyphosphate-5-phosphatase E | Always | In 3 conditions |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Always | In 2 conditions |
| KDM2Blysine demethylase 2B | Always | In 1 condition |
| KDM5Blysine demethylase 5B | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| KICS2KICSTOR subunit 2 | Always | In 1 condition |
| KLHL20kelch like family member 20 | Always | In 1 condition |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| LRRC8Cleucine rich repeat containing 8 VRAC subunit C | Always | In 1 condition |
| MAN1B1mannosidase alpha class 1B member 1 | Always | In 2 conditions |
| MED16mediator complex subunit 16 | Always | In 1 condition |
| MMADHCmetabolism of cobalamin associated D | Always | In 1 condition |
| MSL2MSL complex subunit 2 | Always | In 1 condition |
| NCAPD2non-SMC condensin I complex subunit D2 | Always | In 1 condition |
| NCAPHnon-SMC condensin I complex subunit H | Always | In 1 condition |
Show 173 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NDUFAF1NADH:ubiquinone oxidoreductase complex assembly factor 1 | Always | In 1 condition |
| NDUFAF5NADH:ubiquinone oxidoreductase complex assembly factor 5 | Always | In 1 condition |
| NFIXnuclear factor I X | Always | In 3 conditions |
| NSUN2NOP2/Sun RNA methyltransferase 2 | Always | In 1 condition |
| PDE2Aphosphodiesterase 2A | Always | In 1 condition |
| PGAP1post-GPI attachment to proteins inositol deacylase 1 | Always | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Always | In 1 condition |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Always | In 1 condition |
| PTRH2peptidyl-tRNA hydrolase 2 | Always | In 2 conditions |
| RBMXRNA binding motif protein X-linked | Always | In 2 conditions |
| SARS1seryl-tRNA synthetase 1 | Always | In 1 condition |
| SEL1LSEL1L adaptor subunit of SYVN1 ubiquitin ligase | Always | In 1 condition |
| SGSM3small G protein signaling modulator 3 | Always | In 1 condition |
| SLC9A7solute carrier family 9 member A7 | Always | In 1 condition |
| SYNGAP1synaptic Ras GTPase activating protein 1 | Always | In 2 conditions |
| TAF4TATA-box binding protein associated factor 4 | Always | In 1 condition |
| TOP2BDNA topoisomerase II beta | Always | In 1 condition |
| TTI2TELO2 interacting protein 2 | Always | In 2 conditions |
| UBR5ubiquitin protein ligase E3 component n-recognin 5 | Always | In 1 condition |
| UNC13Aunc-13 homolog A | Always | In 2 conditions |
| UROC1urocanate hydratase 1 | Always | In 1 condition |
| WSB2WD repeat and SOCS box containing 2 | Always | In 1 condition |
| ZBTB11zinc finger and BTB domain containing 11 | Always | In 1 condition |
| ZMYM3zinc finger MYM-type containing 3 | Always | In 1 condition |
| ZNF711ZFX family zinc finger ZNF711 | Always | In 1 condition |
| ALX4ALX homeobox 4 | Very often (80–99%) | In 1 condition |
| AP1S2adaptor related protein complex 1 subunit sigma 2 | Very often (80–99%) | In 2 conditions |
| BCL11ABCL11 transcription factor A | Very often (80–99%) | In 1 condition |
| CAMKMTcalmodulin-lysine N-methyltransferase | Very often (80–99%) | In 1 condition |
| CASKcalcium/calmodulin dependent serine protein kinase | Very often (80–99%) | In 2 conditions |
| CC2D2Acoiled-coil and C2 domain containing 2A | Very often (80–99%) | In 1 condition |
| CDH11cadherin 11 | Very often (80–99%) | In 1 condition |
| CUL4Bcullin 4B | Very often (80–99%) | In 1 condition |
| HPRT1hypoxanthine phosphoribosyltransferase 1 | Very often (80–99%) | In 1 condition |
| HYCC1hyccin PI4KA lipid kinase complex subunit 1 | Very often (80–99%) | In 1 condition |
| LAMA1laminin subunit alpha 1 | Very often (80–99%) | In 1 condition |
| PAN2poly(A) specific ribonuclease subunit PAN2 | Very often (80–99%) | In 1 condition |
| PPM1Bprotein phosphatase, Mg2+/Mn2+ dependent 1B | Very often (80–99%) | In 1 condition |
| PREPLprolyl endopeptidase like | Very often (80–99%) | In 1 condition |
| PUF60poly(U) binding splicing factor 60 | Very often (80–99%) | In 1 condition |
| RDH11retinol dehydrogenase 11 | Very often (80–99%) | In 1 condition |
| RELREL proto-oncogene, NF-kB subunit | Very often (80–99%) | In 1 condition |
| RPGRIP1LRPGRIP1 like | Very often (80–99%) | In 1 condition |
| RPS6KC1ribosomal protein S6 kinase C1 | Very often (80–99%) | In 1 condition |
| SLC3A1solute carrier family 3 member 1 | Very often (80–99%) | In 1 condition |
| TCF4transcription factor 4 | Very often (80–99%) | In 1 condition |
| TMEM67transmembrane protein 67 | Very often (80–99%) | In 2 conditions |
| TMEM70transmembrane protein 70 | Very often (80–99%) | In 1 condition |
| USP9Xubiquitin specific peptidase 9 X-linked | Very often (80–99%) | In 1 condition |
| XPO1exportin 1 | Very often (80–99%) | In 1 condition |
| ADCY5adenylate cyclase 5 | Often (30–79%) | In 1 condition |
| AFG2AAAA ATPase AFG2A | Often (30–79%) | In 1 condition |
| AHDC1AT-hook DNA binding motif containing 1 | Often (30–79%) | In 1 condition |
| ANKRD11ankyrin repeat domain 11 | Often (30–79%) | In 1 condition |
| ARID1AAT-rich interaction domain 1A | Often (30–79%) | In 1 condition |
| ARID1BAT-rich interaction domain 1B | Often (30–79%) | In 1 condition |
| ARID2AT-rich interaction domain 2 | Often (30–79%) | In 2 conditions |
| ARXaristaless related homeobox | Often (30–79%) | In 1 condition |
| BAIAP2BAR/IMD domain containing adaptor protein 2 | Often (30–79%) | In 1 condition |
| CHD8chromodomain helicase DNA binding protein 8 | Often (30–79%) | In 1 condition |
| CHRNA7cholinergic receptor nicotinic alpha 7 subunit | Often (30–79%) | In 1 condition |
| CLCN4Cl-/H+ antiporter 4 | Often (30–79%) | In 1 condition |
| COQ8Acoenzyme Q8A | Often (30–79%) | In 1 condition |
| CWF19L1CWF19 like cell cycle control factor 1 | Often (30–79%) | In 1 condition |
| DCHS1dachsous cadherin-related 1 | Often (30–79%) | In 1 condition |
| DNMT3ADNA methyltransferase 3 alpha | Often (30–79%) | In 1 condition |
| DPAGT1dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 | Often (30–79%) | In 1 condition |
| DPF2double PHD fingers 2 | Often (30–79%) | In 1 condition |
| FAT4FAT atypical cadherin 4 | Often (30–79%) | In 1 condition |
| FBLN1fibulin 1 | Often (30–79%) | In 1 condition |
| FOXP1forkhead box P1 | Often (30–79%) | In 1 condition |
| FZR1fizzy and cell division cycle 20 related 1 | Often (30–79%) | In 1 condition |
| GLUD1glutamate dehydrogenase 1 | Often (30–79%) | In 1 condition |
| GRIA3glutamate ionotropic receptor AMPA type subunit 3 | Often (30–79%) | In 1 condition |
| GTF3C3general transcription factor IIIC subunit 3 | Often (30–79%) | In 1 condition |
| HNRNPKheterogeneous nuclear ribonucleoprotein K | Often (30–79%) | In 2 conditions |
| KLF13KLF transcription factor 13 | Often (30–79%) | In 1 condition |
| L1CAML1 cell adhesion molecule | Often (30–79%) | In 1 condition |
| MAB21L1mab-21 like 1 | Often (30–79%) | In 1 condition |
| MAB21L2mab-21 like 2 | Often (30–79%) | In 1 condition |
| MAGEL2MAGE family member L2 | Often (30–79%) | In 3 conditions |
| MECP2methyl-CpG binding protein 2 | Often (30–79%) | In 1 condition |
| MED12mediator complex subunit 12 | Often (30–79%) | In 1 condition |
| MED13Lmediator complex subunit 13L | Often (30–79%) | In 2 conditions |
| MYT1Lmyelin transcription factor 1 like | Often (30–79%) | In 1 condition |
| NDNnecdin, MAGE family member | Often (30–79%) | In 3 conditions |
| NSD1nuclear receptor binding SET domain protein 1 | Often (30–79%) | In 2 conditions |
| OCA2OCA2 melanosomal transmembrane protein | Often (30–79%) | In 3 conditions |
| OPHN1oligophrenin 1 | Often (30–79%) | In 1 condition |
| PAX1paired box 1 | Often (30–79%) | In 1 condition |
| PCDH19protocadherin 19 | Often (30–79%) | In 2 conditions |
| PGM3phosphoglucomutase 3 | Often (30–79%) | In 1 condition |
| PLP1proteolipid protein 1 | Often (30–79%) | In 2 conditions |
| POLR3ARNA polymerase III subunit A | Often (30–79%) | In 1 condition |
| PPP2R5Dprotein phosphatase 2 regulatory subunit B'delta | Often (30–79%) | In 1 condition |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Often (30–79%) | In 1 condition |
| PSPHphosphoserine phosphatase | Often (30–79%) | In 1 condition |
| RBSNrabenosyn, RAB effector | Often (30–79%) | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Often (30–79%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Often (30–79%) | In 1 condition |
| RNU5B-1RNA, U5B small nuclear 1 | Often (30–79%) | In 1 condition |
| SATB2SATB homeobox 2 | Often (30–79%) | In 1 condition |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Often (30–79%) | In 1 condition |
| SHMT2serine hydroxymethyltransferase 2 | Often (30–79%) | In 1 condition |
| SLC2A1solute carrier family 2 member 1 | Often (30–79%) | In 1 condition |
| SLC6A17solute carrier family 6 member 17 | Often (30–79%) | In 1 condition |
| SMARCA4SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 | Often (30–79%) | In 1 condition |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Often (30–79%) | In 1 condition |
| SMARCC2SWI/SNF related BAF chromatin remodeling complex subunit C2 | Often (30–79%) | In 1 condition |
| SMARCD1SWI/SNF related BAF chromatin remodeling complex subunit D1 | Often (30–79%) | In 1 condition |
| SMARCE1SWI/SNF related BAF chromatin remodeling complex subunit E1 | Often (30–79%) | In 1 condition |
| SMOC1SPARC related modular calcium binding 1 | Often (30–79%) | In 1 condition |
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Often (30–79%) | In 3 conditions |
| SOX11SRY-box transcription factor 11 | Often (30–79%) | In 1 condition |
| SOX4SRY-box transcription factor 4 | Often (30–79%) | In 1 condition |
| SRCAPSnf2 related CREBBP activator protein | Often (30–79%) | In 1 condition |
| SRPK3SRSF protein kinase 3 | Often (30–79%) | In 1 condition |
| STAG2STAG2 cohesin complex component | Often (30–79%) | In 1 condition |
| TAF1TATA-box binding protein associated factor 1 | Often (30–79%) | In 1 condition |
| THOC2THO complex subunit 2 | Often (30–79%) | In 1 condition |
| WARS2tryptophanyl tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| XYLT1xylosyltransferase 1 | Often (30–79%) | In 1 condition |
| YY1YY1 transcription factor | Often (30–79%) | In 1 condition |
| ZSCAN10zinc finger and SCAN domain containing 10 | Often (30–79%) | In 1 condition |
| APC2APC regulator of Wnt signaling pathway 2 | Sometimes (5–29%) | In 1 condition |
| ASXL3ASXL transcriptional regulator 3 | Sometimes (5–29%) | In 1 condition |
| CCNKcyclin K | Sometimes (5–29%) | In 1 condition |
| CNTNAP2contactin associated protein 2 | Sometimes (5–29%) | In 1 condition |
| COG5component of oligomeric golgi complex 5 | Sometimes (5–29%) | In 1 condition |
| COL1A2collagen type I alpha 2 chain | Sometimes (5–29%) | In 1 condition |
| CWC27CWC27 spliceosome associated cyclophilin | Sometimes (5–29%) | In 1 condition |
| DHX9DExH-box helicase 9 | Sometimes (5–29%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Sometimes (5–29%) | In 2 conditions |
| FGFR3fibroblast growth factor receptor 3 | Sometimes (5–29%) | In 1 condition |
| GRIN1glutamate ionotropic receptor NMDA type subunit 1 | Sometimes (5–29%) | In 1 condition |
| GRIN2Aglutamate ionotropic receptor NMDA type subunit 2A | Sometimes (5–29%) | In 1 condition |
| HMGCL3-hydroxy-3-methylglutaryl-CoA lyase | Sometimes (5–29%) | In 1 condition |
| KIF5Akinesin family member 5A | Sometimes (5–29%) | In 1 condition |
| MAU2MAU2 sister chromatid cohesion factor | Sometimes (5–29%) | In 1 condition |
| MED25mediator complex subunit 25 | Sometimes (5–29%) | In 1 condition |
| MT-TEmitochondrially encoded tRNA-Glu (GAA/G) | Sometimes (5–29%) | In 1 condition |
| NAV3neuron navigator 3 | Sometimes (5–29%) | In 1 condition |
| PGAP2post-GPI attachment to proteins 2 | Sometimes (5–29%) | In 1 condition |
| PGAP3post-GPI attachment to proteins phospholipase 3 | Sometimes (5–29%) | In 1 condition |
| PIGLphosphatidylinositol glycan anchor biosynthesis class L | Sometimes (5–29%) | In 1 condition |
| PIGOphosphatidylinositol glycan anchor biosynthesis class O | Sometimes (5–29%) | In 1 condition |
| PIGVphosphatidylinositol glycan anchor biosynthesis class V | Sometimes (5–29%) | In 1 condition |
| PIGWphosphatidylinositol glycan anchor biosynthesis class W | Sometimes (5–29%) | In 1 condition |
| PIGYphosphatidylinositol glycan anchor biosynthesis class Y | Sometimes (5–29%) | In 1 condition |
| POLR3BRNA polymerase III subunit B | Sometimes (5–29%) | In 1 condition |
| PRMT7protein arginine methyltransferase 7 | Sometimes (5–29%) | In 1 condition |
| RNU4-2RNA, U4 small nuclear 2 | Sometimes (5–29%) | In 1 condition |
| RSPRY1ring finger and SPRY domain containing 1 | Sometimes (5–29%) | In 1 condition |
| SLC16A2solute carrier family 16 member 2 | Sometimes (5–29%) | In 1 condition |
| SLC35A3solute carrier family 35 member A3 | Sometimes (5–29%) | In 1 condition |
| TBCDtubulin folding cofactor D | Sometimes (5–29%) | In 1 condition |
| TGM6transglutaminase 6 | Sometimes (5–29%) | In 1 condition |
| TOR1Atorsin family 1 member A | Sometimes (5–29%) | In 1 condition |
| TWIST1twist family bHLH transcription factor 1 | Sometimes (5–29%) | In 2 conditions |
| UBE2Aubiquitin conjugating enzyme E2 A | Sometimes (5–29%) | In 1 condition |
| VPS16VPS16 core subunit of CORVET and HOPS complexes | Sometimes (5–29%) | In 1 condition |
| WBP4WW domain binding protein 4 | Sometimes (5–29%) | In 1 condition |
| WDR62WD repeat domain 62 | Sometimes (5–29%) | In 1 condition |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Not recorded | In 1 condition |
| EBPEBP cholestenol delta-isomerase | Not recorded | In 1 condition |
| ENTPD1ectonucleoside triphosphate diphosphohydrolase 1 | Not recorded | In 1 condition |
| GTF2E2general transcription factor IIE subunit 2 | Not recorded | In 1 condition |
| PTDSS1phosphatidylserine synthase 1 | Not recorded | In 1 condition |
| RTTNrotatin | Not recorded | In 1 condition |
| SHANK3SH3 and multiple ankyrin repeat domains 3 | Not recorded | In 1 condition |
| SLC45A1solute carrier family 45 member 1 | Not recorded | In 1 condition |
| TDO2tryptophan 2,3-dioxygenase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks