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Gene

SGSM3

small G protein signaling modulator 3

Summary

Cytogenetic location
22q13.1
Coordinates
Chromosome 22: 40,370,594–40,410,289 (GRCh38)
Exons
22 exons across 39.7 kb
Protein
749 amino acids
Also known as
DJ1042K10.2, RUSC3, RabGAP-5, RABGAP5
Previous symbols
RUTBC3
MANE Select transcript
ENST00000248929.14NM_015705.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SGSM3 yet. The test sequences your whole genome, so your data includes it all the same.

How SGSM3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 22, with a bracket where SGSM3 sits. SGSM3 and 13 genes near it on chromosome 22, from 39,890,442 to 40,890,441.Chromosome 2222q13.1p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3340 Mb40.2 Mb40.4 Mb40.6 Mb40.8 MbENTHD1: 39,743,044–39,893,864, reverse strandENTHD1GRAP2: 39,901,084–39,973,721, forward strandGRAP2TMA7B: 39,960,397–39,964,905, forward strandTMA7BSACK1F: 39,994,917–40,043,534, forward strandSACK1FTNRC6B: 40,044,756–40,335,808, forward strandTNRC6BADSL: 40,346,461–40,390,463, forward strandADSL: 40,346,529–40,410,054, forward strandSGSM3: 40,370,594–40,410,289, forward strandSGSM3MRTFA: 40,410,281–40,636,726, reverse strandMRTFAMCHR1: 40,679,273–40,682,812, forward strandMCHR1SLC25A17: 40,769,630–40,819,402, reverse strandSLC25A17ST13: 40,824,445–40,856,919, reverse strandST13XPNPEP3: 40,857,054–40,932,815, forward strandXPNPEP3DNAJB7: 40,859,549–40,862,113, reverse strandDNAJB7Diagram of SGSM3: 22 exons on the forward strand of chromosome 22Exon 13: 2 known disease-causing sitesExon 1: 40,370,594–40,370,688, 95 basesExon 2: 40,400,696–40,400,813, 118 basesExon 3: 40,401,593–40,401,675, 83 basesExon 4: 40,402,139–40,402,205, 67 basesExon 5: 40,404,247–40,404,455, 209 basesExon 6: 40,404,557–40,404,664, 108 basesExon 7: 40,405,141–40,405,284, 144 basesExon 8: 40,405,649–40,405,844, 196 basesExon 9: 40,406,078–40,406,223, 146 basesExon 10: 40,406,438–40,406,662, 225 basesExon 11: 40,407,017–40,407,071, 55 basesExon 12: 40,407,201–40,407,328, 128 basesExon 13: 40,407,413–40,407,568, 156 basesExon 14: 40,407,789–40,407,843, 55 basesExon 15: 40,408,071–40,408,120, 50 basesExon 16: 40,408,277–40,408,429, 153 basesExon 17: 40,408,627–40,408,697, 71 basesExon 18: 40,408,794–40,408,842, 49 basesExon 19: 40,408,933–40,409,018, 86 basesExon 20: 40,409,250–40,409,372, 123 basesExon 21: 40,409,465–40,409,525, 61 basesExon 22: 40,409,682–40,410,289, 608 bases1225′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3 kb of the gene's 39.7 kb; 2,250 of those bases code for the protein.

How a genome test reads SGSM3

2

positions in SGSM3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 39.7 kb of SGSM3, introns included, not only the 3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SGSM3 gene: small G protein signaling modulator 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/sgsm3

Vancouver

Dante Labs. SGSM3 gene: small G protein signaling modulator 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/sgsm3

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