Skip to content
Use your HSA or FSA funds

Gene

GRIN1

glutamate ionotropic receptor NMDA type subunit 1

Summary

Cytogenetic location
9q34.3
Coordinates
Chromosome 9: 137,139,154–137,168,756 (GRCh38)
Exons
20 exons across 29.6 kb
Protein
938 amino acids
Also known as
GluN1, NR1
Previous symbols
NMDAR1
MANE Select transcript
ENST00000371561.8NM_007327.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • 1 GenCC submitter rates it definitive or strong

    • Intellectual Disability

      • One of 233 genes linked to it

        • 3 GenCC submitters rate it definitive or strong

    How GRIN1 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 9, with a bracket where GRIN1 sits. GRIN1 and 63 genes near it on chromosome 9, from 136,653,955 to 137,653,954.Chromosome 99q34.3p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.3136.8 Mb137 Mb137.2 Mb137.4 Mb137.6 MbEGFL7: 136,658,284–136,672,684, forward strandEGFL7AGPAT2: 136,673,142–136,687,483, reverse strandAGPAT2DIPK1B: 136,712,302–136,724,742, forward strand: 136,738,167–136,748,453, reverse strandLCN10: 136,738,167–136,743,356, reverse strandLCN6: 136,744,017–136,748,531, reverse strandLCN6LCN8: 136,754,386–136,758,543, reverse strandLCN8LCN15: 136,759,634–136,766,255, reverse strandLCN15TMEM141: 136,791,303–136,793,317, forward strand: 136,791,379–136,800,595, forward strandCCDC183: 136,796,338–136,807,741, forward strandRABL6: 136,807,848–136,841,187, forward strandAJM1: 136,842,478–136,848,801, forward strandAJM1PHPT1: 136,847,994–136,851,043, forward strandPHPT1MAMDC4: 136,850,943–136,860,802, forward strandMAMDC4EDF1: 136,862,113–136,866,343, reverse strandEDF1TRAF2: 136,881,903–136,929,221, forward strandTRAF2FBXW5: 136,938,431–136,950,122, reverse strandC8G: 136,942,532–136,946,980, forward strandC8GLCN12: 136,949,391–136,956,535, forward strandPTGDS: 136,975,053–136,981,750, forward strand: 136,977,518–136,985,435, forward strandLCNL1: 136,981,904–136,986,410, forward strandLCNL1PAXX: 136,992,400–136,994,074, forward strandPAXXCLIC3: 136,994,608–136,996,729, reverse strandCLIC3ABCA2: 137,007,226–137,028,915, reverse strandFUT7: 137,030,174–137,032,825, reverse strand: 137,031,241–137,040,436, reverse strandNPDC1: 137,037,577–137,046,700, reverse strandENTPD2: 137,048,107–137,054,069, reverse strandENTPD2SAPCD2: 137,062,127–137,070,593, reverse strandSAPCD2UAP1L1: 137,077,470–137,084,544, forward strandUAP1L1MAN1B1: 137,085,917–137,109,189, forward strandMAN1B1DPP7: 137,110,540–137,118,309, reverse strandDPP7GRIN1: 137,139,154–137,168,756, forward strandGRIN1LRRC26: 137,168,758–137,170,058, reverse strandLRRC26: 137,168,854–137,171,984, reverse strandTMEM210: 137,170,858–137,172,056, reverse strandTMEM210ANAPC2: 137,174,784–137,189,028, reverse strandSSNA1: 137,188,640–137,190,371, forward strandTPRN: 137,191,617–137,204,193, reverse strandTMEM203: 137,204,082–137,205,648, reverse strandNDOR1: 137,205,662–137,219,371, forward strandRNF229: 137,217,494–137,219,361, forward strandRNF208: 137,219,577–137,222,312, reverse strandCYSRT1: 137,225,174–137,226,315, forward strandCYSRT1RNF224: 137,226,908–137,229,640, forward strandSLC34A3: 137,230,757–137,236,555, forward strandTUBB4B: 137,241,278–137,243,713, forward strandTUBB4BCIMIP2A: 137,243,584–137,247,770, reverse strandSTPG3: 137,250,608–137,253,483, forward strandSTPG3NELFB: 137,255,210–137,273,542, forward strandTOR4A: 137,274,854–137,282,641, forward strandNRARP: 137,299,631–137,302,271, reverse strandNRARPEXD3: 137,306,894–137,423,911, reverse strandEXD3NOXA1: 137,422,752–137,434,451, forward strandNOXA1ENTPD8: 137,434,362–137,441,881, reverse strandENTPD8NSMF: 137,447,570–137,459,576, reverse strandNSMFPNPLA7: 137,459,952–137,550,560, reverse strandPNPLA7MRPL41: 137,550,424–137,552,555, forward strandMRPL41DPH7: 137,554,436–137,578,936, reverse strandDPH7ZMYND19: 137,582,066–137,590,520, reverse strandZMYND19ARRDC1: 137,605,619–137,617,859, forward strandARRDC1EHMT1: 137,618,901–137,870,016, forward strandEHMT1Diagram of GRIN1: 20 exons on the forward strand of chromosome 9Exon 1: 2 known disease-causing sitesExon 2: 3 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 4: 1 known disease-causing siteExon 5: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 9: 3 known disease-causing sitesExon 10: 2 known disease-causing sitesExon 11: 3 known disease-causing sitesExon 12: 9 known disease-causing sitesExon 13: 8 known disease-causing sitesExon 14: 20 known disease-causing sitesExon 15: 4 known disease-causing sitesExon 16: 4 known disease-causing sitesExon 17: 11 known disease-causing sitesExon 18: 7 known disease-causing sitesExon 20: 1 known disease-causing siteExon 1: 137,139,154–137,139,744, 591 basesExon 2: 137,142,013–137,142,147, 135 basesExon 3: 137,145,726–137,145,902, 177 basesExon 4: 137,149,009–137,149,109, 101 basesExon 5: 137,156,669–137,156,790, 122 basesExon 6: 137,156,863–137,157,037, 175 basesExon 7: 137,158,379–137,158,523, 145 basesExon 8: 137,158,621–137,158,704, 84 basesExon 9: 137,161,056–137,161,197, 142 basesExon 10: 137,161,289–137,161,416, 128 basesExon 11: 137,161,924–137,162,088, 165 basesExon 12: 137,162,172–137,162,290, 119 basesExon 13: 137,162,404–137,162,516, 113 basesExon 14: 137,162,591–137,162,739, 149 basesExon 15: 137,162,846–137,163,003, 158 basesExon 16: 137,163,169–137,163,330, 162 basesExon 17: 137,163,559–137,163,668, 110 basesExon 18: 137,163,759–137,163,904, 146 basesExon 19: 137,165,186–137,165,296, 111 basesExon 20: 137,167,411–137,168,756, 1,346 bases151015205′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 4.4 kb of the gene's 29.6 kb; 2,817 of those bases code for the protein.

    How a genome test reads GRIN1

    94

    positions in GRIN1 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 29.6 kb of GRIN1, introns included, not only the 4.4 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). GRIN1 gene: glutamate ionotropic receptor NMDA type subunit 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/grin1

    Vancouver

    Dante Labs. GRIN1 gene: glutamate ionotropic receptor NMDA type subunit 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/grin1

    One test. A lifetime of answers.

    From $449Free shipping · Results in 6–8 weeks

    Get my Genome Test