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Gene

SNRPN

small nuclear ribonucleoprotein polypeptide N

Summary

Cytogenetic location
15q11.2
Coordinates
Chromosome 15: 24,954,987–24,978,723 (GRCh38)
Exons
10 exons across 23.7 kb
Protein
240 amino acids
Also known as
SMN, SM-D, HCERN3, SNRNP-N, SNURF-SNRPN, RT-LI
Previous symbols
PWCR
MANE Select transcript
ENST00000390687.9NM_003097.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • 1 GenCC submitter rates it definitive or strong

  • Imprinting Disorders: Prader-Willi, Silver-Russell and Beckwith-Wiedemann

    • Prader-Willi syndrome

      A condition caused by loss of the paternally inherited 15q11-q13 region, causing low muscle tone and feeding difficulties in infancy followed by excessive appetite, obesity, short stature, hypogonadism and learning difficulties.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Early diagnosis allows growth hormone treatment, dietary management and hormone monitoring.

How SNRPN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 15, with a bracket where SNRPN sits. SNRPN and 4 genes near it on chromosome 15, from 24,466,855 to 25,466,854.Chromosome 1515q11.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.324.6 Mb24.8 Mb25 Mb25.2 Mb25.4 MbNPAP1: 24,675,775–24,683,393, forward strandNPAP1SNURF: 24,954,920–24,977,850, forward strandSNURFSNRPN: 24,954,987–24,978,723, forward strandSNRPN: 24,955,034–25,000,276, forward strandUBE3A: 25,333,728–25,439,122, reverse strandUBE3ADiagram of SNRPN: 10 exons on the forward strand of chromosome 15Exon 1: 24,954,987–24,955,062, 76 basesExon 2: 24,962,114–24,962,209, 96 basesExon 3: 24,967,932–24,968,082, 151 basesExon 4: 24,974,311–24,974,456, 146 basesExon 5: 24,975,358–24,975,509, 152 basesExon 6: 24,976,305–24,976,416, 112 basesExon 7: 24,976,877–24,977,029, 153 basesExon 8: 24,977,778–24,977,916, 139 basesExon 9: 24,978,193–24,978,318, 126 basesExon 10: 24,978,407–24,978,723, 317 bases12468105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.5 kb of the gene's 23.7 kb; 723 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SNRPN gene: small nuclear ribonucleoprotein polypeptide N. Retrieved 17 October 2026, from https://dantelabs.com/genes/snrpn

Vancouver

Dante Labs. SNRPN gene: small nuclear ribonucleoprotein polypeptide N [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/snrpn

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