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Gene

FZR1

fizzy and cell division cycle 20 related 1

Summary

Cytogenetic location
19p13.3
Coordinates
Chromosome 19: 3,506,311–3,538,334 (GRCh38)
Exons
14 exons across 32 kb
Protein
493 amino acids
Also known as
HCDH1, CDH1, HCDH, FZR, FZR2, KIAA1242, CDC20C
MANE Select transcript
ENST00000441788.7NM_016263.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • 3 GenCC submitters rate it definitive or strong

    How FZR1 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Stretches short reads find hard
    Chromosome 19, with a bracket where FZR1 sits. FZR1 and 29 genes near it on chromosome 19, from 3,022,323 to 4,022,322.Chromosome 1919p13.3p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.433.2 Mb3.4 Mb3.6 Mb3.8 Mb4 MbTLE2: 2,997,632–3,047,635, reverse strandTLE2TLE5: 3,052,908–3,063,112, reverse strandTLE5GNA11: 3,094,320–3,124,001, forward strandGNA11GNA15: 3,136,027–3,163,749, forward strandGNA15S1PR4: 3,172,346–3,180,332, forward strandS1PR4NCLN: 3,185,563–3,209,575, forward strandNCLNCELF5: 3,224,636–3,297,076, forward strandCELF5NFIC: 3,314,403–3,469,217, forward strandNFICSMIM24: 3,473,986–3,480,557, reverse strandSMIM44: 3,482,110–3,483,441, reverse strandSMIM44DOHH: 3,490,821–3,507,203, reverse strandDOHHFZR1: 3,506,311–3,538,334, forward strandFZR1MFSD12: 3,538,261–3,574,290, reverse strandMFSD12TEKTIP1: 3,539,169–3,544,030, forward strandTEKTIP1HMG20B: 3,572,692–3,579,088, forward strandHMG20BGIPC3: 3,585,474–3,593,541, forward strandGIPC3TBXA2R: 3,594,506–3,606,900, reverse strandCACTIN: 3,610,643–3,626,833, reverse strandCACTINPIP5K1C: 3,630,181–3,700,506, reverse strandPIP5K1CTJP3: 3,708,310–3,750,813, forward strandTJP3APBA3: 3,750,772–3,761,700, reverse strandAPBA3MRPL54: 3,761,841–3,769,033, forward strandMRPL54RAX2: 3,769,089–3,772,238, reverse strandRAX2MATK: 3,777,969–3,802,129, reverse strandMATKZFR2: 3,804,024–3,869,055, reverse strandZFR2ATCAY: 3,879,864–3,928,082, forward strandATCAYNMRK2: 3,932,994–3,943,081, forward strandNMRK2DAPK3: 3,958,453–3,971,130, reverse strandDAPK3EEF2: 3,976,044–3,985,479, reverse strandEEF2PIAS4: 4,007,690–4,039,386, forward strandPIAS4Diagram of FZR1: 14 exons on the forward strand of chromosome 19Exon 1: 3,506,311–3,506,474, 164 basesExon 2: 3,522,956–3,523,058, 103 basesExon 3: 3,525,868–3,525,993, 126 basesExon 4: 3,526,120–3,526,183, 64 basesExon 5: 3,526,259–3,526,386, 128 basesExon 6: 3,526,980–3,527,062, 83 basesExon 7: 3,527,631–3,527,814, 184 basesExon 8: 3,530,792–3,530,857, 66 basesExon 9: 3,531,714–3,531,816, 103 basesExon 10: 3,531,911–3,532,095, 185 basesExon 11: 3,532,417–3,532,650, 234 basesExon 12: 3,533,294–3,533,398, 105 basesExon 13: 3,534,421–3,534,513, 93 basesExon 14: 3,534,795–3,538,334, 3,540 bases124681012145′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 5.2 kb of the gene's 32 kb; 1,482 of those bases code for the protein.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). FZR1 gene: fizzy and cell division cycle 20 related 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/fzr1

    Vancouver

    Dante Labs. FZR1 gene: fizzy and cell division cycle 20 related 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fzr1

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