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Gene

KIF5A

kinesin family member 5A

Summary

Cytogenetic location
12q13.3
Coordinates
Chromosome 12: 57,550,044–57,586,633 (GRCh38)
Exons
29 exons across 36.6 kb
Protein
1,032 amino acids
Also known as
D12S1889, NKHC, MY050
Previous symbols
SPG10
MANE Select transcript
ENST00000455537.7NM_004984.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Hereditary Spastic Paraplegia

      • Hereditary Spastic Paraplegia (All Types)

        One of 66 genes linked to it

        Umbrella term covering all hereditary spastic paraplegias, including SPG4 (SPAST), the most common dominant form, and SPG5A, SPG6, SPG10, SPG18, SPG30 and SPG31.

        • 4 GenCC submitters rate it definitive or strong

    How KIF5A is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 12, with a bracket where KIF5A sits. KIF5A and 37 genes near it on chromosome 12, from 57,068,339 to 58,068,338.Chromosome 1212q13.3p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3357.2 Mb57.4 Mb57.6 Mb57.8 Mb58 MbNEMP1: 57,055,641–57,088,063, reverse strandNEMP1NAB2: 57,088,883–57,095,476, forward strandNAB2STAT6: 57,095,403–57,132,139, reverse strandSTAT6LRP1: 57,128,476–57,213,394, forward strandLRP1NXPH4: 57,216,780–57,226,449, forward strandNXPH4SHMT2: 57,226,554–57,234,935, forward strandCOXFA4L2: 57,234,541–57,242,750, reverse strandCOXFA4L2STAC3: 57,243,453–57,251,195, reverse strandSTAC3: 57,249,609–57,296,484, reverse strandR3HDM2: 57,253,762–57,431,051, reverse strandR3HDM2INHBC: 57,434,700–57,452,067, forward strandINHBCINHBE: 57,452,323–57,459,280, forward strandINHBEGLI1: 57,459,783–57,472,268, forward strandGLI1ARHGAP9: 57,472,260–57,488,831, reverse strandMARS1: 57,475,445–57,517,702, forward strandDDIT3: 57,516,584–57,523,630, reverse strandDDIT3: 57,517,712–57,520,480, reverse strandMBD6: 57,520,710–57,530,614, forward strandMBD6DCTN2: 57,529,567–57,547,256, reverse strandDCTN2KIF5A: 57,550,044–57,586,633, forward strandKIF5APIP4K2C: 57,591,161–57,603,418, forward strandPIP4K2CDTX3: 57,604,484–57,609,804, forward strandDTX3ARHGEF25: 57,610,111–57,617,245, forward strandARHGEF25: 57,615,280–57,626,125, forward strandB4GALNT1: 57,623,409–57,633,242, reverse strandOS9: 57,693,841–57,728,342, forward strandOS9AGAP2: 57,723,761–57,742,209, reverse strandAGAP2TSPAN31: 57,738,013–57,751,383, forward strandTSPAN31CDK4: 57,746,043–57,756,013, reverse strandCDK4MARCHF9: 57,754,940–57,760,411, forward strandCYP27B1: 57,762,334–57,768,986, reverse strandMETTL1: 57,768,471–57,772,131, reverse strandEEF1AKMT3: 57,771,492–57,782,544, forward strand: 57,772,660–57,797,554, forward strandTSFM: 57,782,731–57,828,655, forward strandTSFMAVIL: 57,797,376–57,818,734, reverse strandAVILCTDSP2: 57,819,925–57,846,976, reverse strandCTDSP2ATP23: 57,906,039–57,959,148, forward strandATP23Diagram of KIF5A: 29 exons on the forward strand of chromosome 12Exon 2: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 8: 6 known disease-causing sitesExon 9: 8 known disease-causing sitesExon 10: 8 known disease-causing sitesExon 16: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 24: 1 known disease-causing siteExon 25: 4 known disease-causing sitesExon 26: 1 known disease-causing siteExon 1: 57,550,044–57,550,400, 357 basesExon 2: 57,563,439–57,563,526, 88 basesExon 3: 57,563,620–57,563,693, 74 basesExon 4: 57,564,108–57,564,212, 105 basesExon 5: 57,564,460–57,564,508, 49 basesExon 6: 57,564,918–57,564,973, 56 basesExon 7: 57,567,126–57,567,213, 88 basesExon 8: 57,567,494–57,567,618, 125 basesExon 9: 57,568,963–57,569,067, 105 basesExon 10: 57,569,256–57,569,404, 149 basesExon 11: 57,569,535–57,569,683, 149 basesExon 12: 57,569,987–57,570,162, 176 basesExon 13: 57,571,321–57,571,389, 69 basesExon 14: 57,572,061–57,572,267, 207 basesExon 15: 57,572,580–57,572,726, 147 basesExon 16: 57,575,084–57,575,272, 189 basesExon 17: 57,575,640–57,575,757, 118 basesExon 18: 57,576,087–57,576,151, 65 basesExon 19: 57,576,269–57,576,378, 110 basesExon 20: 57,576,761–57,576,862, 102 basesExon 21: 57,577,713–57,577,773, 61 basesExon 22: 57,578,009–57,578,080, 72 basesExon 23: 57,578,238–57,578,342, 105 basesExon 24: 57,580,956–57,581,172, 217 basesExon 25: 57,581,415–57,581,568, 154 basesExon 26: 57,581,870–57,581,952, 83 basesExon 27: 57,582,602–57,582,629, 28 basesExon 28: 57,583,101–57,583,215, 115 basesExon 29: 57,584,218–57,586,633, 2,416 bases1510152025295′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 5.8 kb of the gene's 36.6 kb; 3,099 of those bases code for the protein.

    How a genome test reads KIF5A

    37

    positions in KIF5A where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 36.6 kb of KIF5A, introns included, not only the 5.8 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). KIF5A gene: kinesin family member 5A. Retrieved 17 October 2026, from https://dantelabs.com/genes/kif5a

    Vancouver

    Dante Labs. KIF5A gene: kinesin family member 5A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kif5a

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