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Gene

GRIN2A

glutamate ionotropic receptor NMDA type subunit 2A

Summary

Cytogenetic location
16p13.2
Coordinates
Chromosome 16: 9,753,408–10,182,428 (GRCh38)
Exons
13 exons across 429 kb
Protein
1,464 amino acids
Also known as
GluN2A, NR2A
Previous symbols
NMDAR2A
MANE Select transcript
ENST00000330684.4NM_001134407.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • 4 GenCC submitters rate it definitive or strong

    How GRIN2A is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 16, with a bracket where GRIN2A sits. GRIN2A and 2 genes near it on chromosome 16, from 9,324,387 to 10,611,449.Chromosome 1616p13.2p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.39.4 Mb9.6 Mb9.8 Mb10 Mb10.2 Mb10.4 Mb10.6 MbGRIN2A: 9,753,408–10,182,428, reverse strandGRIN2AATF7IP2: 10,326,434–10,483,640, forward strandATF7IP2EMP2: 10,528,422–10,580,857, reverse strandEMP2Diagram of GRIN2A: 13 exons on the reverse strand of chromosome 16Exon 13: 27 known disease-causing sitesExon 12: 13 known disease-causing sitesExon 11: 12 known disease-causing sitesExon 10: 21 known disease-causing sitesExon 9: 28 known disease-causing sitesExon 8: 10 known disease-causing sitesExon 7: 19 known disease-causing sitesExon 6: 10 known disease-causing sitesExon 5: 14 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 3: 26 known disease-causing sitesExon 2: 22 known disease-causing sitesExon 13: 9,753,408–9,764,948, 11,541 basesExon 12: 9,768,851–9,769,089, 239 basesExon 11: 9,798,277–9,798,464, 188 basesExon 10: 9,822,264–9,822,424, 161 basesExon 9: 9,829,423–9,829,652, 230 basesExon 8: 9,834,105–9,834,230, 126 basesExon 7: 9,840,647–9,840,800, 154 basesExon 6: 9,840,936–9,841,104, 169 basesExon 5: 9,849,756–9,849,961, 206 basesExon 4: 9,890,986–9,891,100, 115 basesExon 3: 9,937,959–9,938,551, 593 basesExon 2: 10,179,998–10,180,429, 432 basesExon 1: 10,181,877–10,182,428, 552 bases1310515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 14.7 kb of the gene's 429 kb; 4,395 of those bases code for the protein.

    How a genome test reads GRIN2A

    234

    positions in GRIN2A where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 429 kb of GRIN2A, introns included, not only the 14.7 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). GRIN2A gene: glutamate ionotropic receptor NMDA type subunit 2A. Retrieved 17 October 2026, from https://dantelabs.com/genes/grin2a

    Vancouver

    Dante Labs. GRIN2A gene: glutamate ionotropic receptor NMDA type subunit 2A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/grin2a

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