Gene
WSB2
WD repeat and SOCS box containing 2
- HGNC 19222↗(opens in a new tab)
- Ensembl gene ENSG00000176871↗(opens in a new tab)
- NCBI Gene 55884↗(opens in a new tab)
Summary
- Cytogenetic location
- 12q24.23
- Coordinates
- Chromosome 12: 118,032,687–118,061,179 (GRCh38)
- Exons
- 9 exons across 28.5 kb
- Protein
- 404 amino acids
- Also known as
- SBA2, MGC10210
- MANE Select transcript
- ENST00000315436.8NM_018639.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How WSB2 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 2.9 kb of the gene's 28.5 kb; 1,215 of those bases code for the protein.
Traits linked to WSB2
The Human Phenotype Ontology lists these as features of the rare conditions WSB2 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Abnormal anterior horn cell morphology
- Abnormal gait
- Absent speech development
- Attention deficit
- Colpocephaly
- Delayed fine motor development
- Delayed speech and language development
- Fewer and broader ridges in brain
Show 23 more traits
- Global developmental delay
- Gray matter heterotopia
- Happy demeanor
- Intellectual disability
- IQ between 34 and 49
- Lethargy
- Obstructive sleep apnea
- Poor eye contact
- Delayed motor skills
- Autism
- Brisk reflexes
- Cerebellar vermis hypoplasia
- Epilepsy
- Recurrent hand flapping
- Small cerebellum
- Underdevelopment of part of brain called corpus callosum
- Chorea
- CNS hypomyelination
- Degeneration of cerebellum
- Hypoplasia of the olfactory bulb
- Simplified gyral pattern
- Small hippocampus
- Thin corpus callosum
Abnormality of head or neck
- Small forehead
- Small head present at birth
- Upward slanting of the opening between the eyelids
- Abnormally small head
- High palate
- Little lower jaw
- Long face
- Low frontal hairline
Show 2 more traits
Abnormality of the eye
- Asymmetric pupil sizes
- Congenital drooping upper eyelid
- Involuntary, rapid, rhythmic eye movements
- Deeply set eye
- Farsightedness
- Bulging eye
- Cerebral visual impairment
- Inward turning cross eyed
Show 2 more traits
External links
Gene records
Transcript
Protein
Clinical
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). WSB2 gene: WD repeat and SOCS box containing 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/wsb2
Dante Labs. WSB2 gene: WD repeat and SOCS box containing 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/wsb2
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