Skip to content
Use your HSA or FSA funds

Gene

MED25

mediator complex subunit 25

Summary

Cytogenetic location
19q13.33
Coordinates
Chromosome 19: 49,818,289–49,836,979 (GRCh38)
Exons
18 exons across 18.7 kb
Protein
747 amino acids
Also known as
ARC92, ACID1, TCBAP0758, DKFZp434K0512
MANE Select transcript
ENST00000312865.10NM_030973.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads MED25 yet. The test sequences your whole genome, so your data includes it all the same.

How MED25 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where MED25 sits. MED25 and 43 genes near it on chromosome 19, from 49,327,634 to 50,327,633.Chromosome 1919q13.33p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4349.4 Mb49.6 Mb49.8 Mb50 Mb50.2 MbCD37: 49,335,171–49,343,335, forward strandCD37TEAD2: 49,340,389–49,362,729, reverse strandTEAD2DKKL1: 49,361,783–49,375,120, forward strandDKKL1KASH5: 49,388,219–49,417,990, forward strandKASH5PTH2: 49,422,419–49,423,660, reverse strandPTH2GFY: 49,423,749–49,428,987, forward strandGFYSLC17A7: 49,429,399–49,443,197, reverse strandPIH1D1: 49,446,291–49,453,537, reverse strandALDH16A1: 49,453,146–49,471,052, forward strand: 49,462,752–49,486,231, forward strandFLT3LG: 49,474,150–49,486,233, forward strandFLT3LGRPL13A: 49,487,510–49,493,057, forward strandRPL13ARPS11: 49,496,233–49,499,903, forward strandRPS11FCGRT: 49,506,806–49,526,917, forward strandFCGRTRCN3: 49,526,534–49,579,703, forward strandRCN3NOSIP: 49,555,207–49,592,927, reverse strandNOSIPPRRG2: 49,580,646–49,591,004, forward strandPRRG2PRR12: 49,591,108–49,626,439, forward strandPRR12RRAS: 49,634,555–49,640,211, reverse strandRRASSCAF1: 49,640,488–49,658,649, forward strandIRF3: 49,659,569–49,665,864, reverse strandBCL2L12: 49,664,622–49,673,917, forward strandBCL2L12PRMT1: 49,675,786–49,689,029, forward strandPRMT1ADM5: 49,688,953–49,690,575, forward strandADM5CPT1C: 49,690,898–49,713,733, forward strandCPT1CTSKS: 49,739,753–49,763,329, reverse strandTSKSAP2A1: 49,766,912–49,807,114, forward strandAP2A1FUZ: 49,806,866–49,817,376, reverse strandFUZMED25: 49,818,289–49,836,979, forward strandMED25PTOV1: 49,850,735–49,860,744, forward strandPTOV1PNKP: 49,859,882–49,878,351, reverse strandPNKPAKT1S1: 49,869,023–49,879,470, reverse strandAKT1S1TBC1D17: 49,877,501–49,888,751, forward strandIL4I1: 49,889,654–49,929,926, reverse strandIL4I1NUP62: 49,906,825–49,929,926, reverse strandNUP62: 49,909,501–49,958,391, reverse strandATF5: 49,923,910–49,933,935, forward strandATF5SIGLEC11: 49,948,910–49,961,172, reverse strandSIGLEC16: 49,969,600–49,975,819, forward strandVRK3: 49,974,537–50,025,946, reverse strandVRK3ZNF473: 50,025,714–50,053,414, forward strandZNF473IZUMO2: 50,152,537–50,163,281, reverse strandIZUMO2MYH14: 50,188,181–50,310,545, forward strandMYH14KCNC3: 50,311,937–50,333,515, reverse strandKCNC3Diagram of MED25: 18 exons on the forward strand of chromosome 19Exon 1: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 6: 2 known disease-causing sitesExon 7: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 14: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 1: 49,818,289–49,818,475, 187 basesExon 2: 49,818,571–49,818,616, 46 basesExon 3: 49,819,172–49,819,296, 125 basesExon 4: 49,828,449–49,828,547, 99 basesExon 5: 49,828,970–49,829,090, 121 basesExon 6: 49,829,786–49,829,948, 163 basesExon 7: 49,830,088–49,830,218, 131 basesExon 8: 49,830,511–49,830,598, 88 basesExon 9: 49,830,694–49,830,887, 194 basesExon 10: 49,831,333–49,831,461, 129 basesExon 11: 49,831,936–49,832,021, 86 basesExon 12: 49,832,100–49,832,157, 58 basesExon 13: 49,832,308–49,832,415, 108 basesExon 14: 49,834,986–49,835,177, 192 basesExon 15: 49,835,534–49,835,605, 72 basesExon 16: 49,835,727–49,835,945, 219 basesExon 17: 49,836,226–49,836,406, 181 basesExon 18: 49,836,847–49,836,979, 133 bases151015185′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.3 kb of the gene's 18.7 kb; 2,244 of those bases code for the protein.

How a genome test reads MED25

11

positions in MED25 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 18.7 kb of MED25, introns included, not only the 2.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MED25 gene: mediator complex subunit 25. Retrieved 16 October 2026, from https://dantelabs.com/genes/med25

Vancouver

Dante Labs. MED25 gene: mediator complex subunit 25 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/med25

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test